Sensing Lipids with Mincle: Structure and Function
Mincle is a C-type lectin receptor that has emerged as an important player in innate immunity through its capacity to recognize a wide range of lipidic species derived from damaged/altered self and foreign microorganisms. Self-ligands include sterols (e.g., cholesterol), and β-glucosylceramides, and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01662/full |
| _version_ | 1818245428183826432 |
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| author | Spencer J. Williams |
| author_facet | Spencer J. Williams |
| author_sort | Spencer J. Williams |
| collection | DOAJ |
| description | Mincle is a C-type lectin receptor that has emerged as an important player in innate immunity through its capacity to recognize a wide range of lipidic species derived from damaged/altered self and foreign microorganisms. Self-ligands include sterols (e.g., cholesterol), and β-glucosylceramides, and the protein SAP130, which is released upon cell death. Foreign lipids comprise those from both microbial pathogens and commensals and include glycerol, glucose and trehalose mycolates, and glycosyl diglycerides. A large effort has focused on structural variation of these ligands to illuminate the structure–activity relationships required for the agonism of signaling though Mincle and has helped identify key differences in ligand recognition between human and rodent Mincle. These studies in turn have helped identify new Mincle ligands, further broadening our understanding of the diversity of organisms and lipidic species recognized by Mincle. Finally, progress toward the development of Mincle agonists as vaccine adjuvants providing humoral and cell-mediated immunity with reduced toxicity is discussed. |
| first_indexed | 2024-12-12T14:32:45Z |
| format | Article |
| id | doaj.art-476fb4e626b943be8af6d0b3767eb3d8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T14:32:45Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-476fb4e626b943be8af6d0b3767eb3d82022-12-22T00:21:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-11-01810.3389/fimmu.2017.01662317444Sensing Lipids with Mincle: Structure and FunctionSpencer J. Williams0School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, AustraliaMincle is a C-type lectin receptor that has emerged as an important player in innate immunity through its capacity to recognize a wide range of lipidic species derived from damaged/altered self and foreign microorganisms. Self-ligands include sterols (e.g., cholesterol), and β-glucosylceramides, and the protein SAP130, which is released upon cell death. Foreign lipids comprise those from both microbial pathogens and commensals and include glycerol, glucose and trehalose mycolates, and glycosyl diglycerides. A large effort has focused on structural variation of these ligands to illuminate the structure–activity relationships required for the agonism of signaling though Mincle and has helped identify key differences in ligand recognition between human and rodent Mincle. These studies in turn have helped identify new Mincle ligands, further broadening our understanding of the diversity of organisms and lipidic species recognized by Mincle. Finally, progress toward the development of Mincle agonists as vaccine adjuvants providing humoral and cell-mediated immunity with reduced toxicity is discussed.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01662/fullMincleadjuvantstructure–activity relationshipglycolipidsC-type lectin receptorcell-mediated immunity |
| spellingShingle | Spencer J. Williams Sensing Lipids with Mincle: Structure and Function Frontiers in Immunology Mincle adjuvant structure–activity relationship glycolipids C-type lectin receptor cell-mediated immunity |
| title | Sensing Lipids with Mincle: Structure and Function |
| title_full | Sensing Lipids with Mincle: Structure and Function |
| title_fullStr | Sensing Lipids with Mincle: Structure and Function |
| title_full_unstemmed | Sensing Lipids with Mincle: Structure and Function |
| title_short | Sensing Lipids with Mincle: Structure and Function |
| title_sort | sensing lipids with mincle structure and function |
| topic | Mincle adjuvant structure–activity relationship glycolipids C-type lectin receptor cell-mediated immunity |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01662/full |
| work_keys_str_mv | AT spencerjwilliams sensinglipidswithminclestructureandfunction |