Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications
Extracellular vesicles (EVs) are heterogenous membrane-encapsulated vesicles secreted by every cell into the extracellular environment. EVs carry bioactive molecules, including proteins, lipids, DNA, and different RNA forms, which can be internalized by recipient cells, thus altering their biologica...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/22/5633 |
| _version_ | 1797510929716346880 |
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| author | Michela Saviana Giulia Romano Patricia Le Mario Acunzo Patrick Nana-Sinkam |
| author_facet | Michela Saviana Giulia Romano Patricia Le Mario Acunzo Patrick Nana-Sinkam |
| author_sort | Michela Saviana |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are heterogenous membrane-encapsulated vesicles secreted by every cell into the extracellular environment. EVs carry bioactive molecules, including proteins, lipids, DNA, and different RNA forms, which can be internalized by recipient cells, thus altering their biological characteristics. Given that EVs are commonly found in most body fluids, they have been widely described as mediators of communication in several physiological and pathological processes, including cancer. Moreover, their easy detection in biofluids makes them potentially useful candidates as tumor biomarkers. In this manuscript, we review the current knowledge regarding EVs and non-coding RNAs and their role as drivers of the metastatic process in lung cancer. Furthermore, we present the most recent applications for EVs and non-coding RNAs as cancer therapeutics and their relevance as clinical biomarkers. |
| first_indexed | 2024-03-10T05:39:14Z |
| format | Article |
| id | doaj.art-476fcc03045142a99dd13a3fe751746a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T05:39:14Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-476fcc03045142a99dd13a3fe751746a2023-11-22T22:41:02ZengMDPI AGCancers2072-66942021-11-011322563310.3390/cancers13225633Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical ApplicationsMichela Saviana0Giulia Romano1Patricia Le2Mario Acunzo3Patrick Nana-Sinkam4Department of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA 23298, USAExtracellular vesicles (EVs) are heterogenous membrane-encapsulated vesicles secreted by every cell into the extracellular environment. EVs carry bioactive molecules, including proteins, lipids, DNA, and different RNA forms, which can be internalized by recipient cells, thus altering their biological characteristics. Given that EVs are commonly found in most body fluids, they have been widely described as mediators of communication in several physiological and pathological processes, including cancer. Moreover, their easy detection in biofluids makes them potentially useful candidates as tumor biomarkers. In this manuscript, we review the current knowledge regarding EVs and non-coding RNAs and their role as drivers of the metastatic process in lung cancer. Furthermore, we present the most recent applications for EVs and non-coding RNAs as cancer therapeutics and their relevance as clinical biomarkers.https://www.mdpi.com/2072-6694/13/22/5633extracellular vesiclesmetastasislung cancernon-coding RNAtherapy |
| spellingShingle | Michela Saviana Giulia Romano Patricia Le Mario Acunzo Patrick Nana-Sinkam Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications Cancers extracellular vesicles metastasis lung cancer non-coding RNA therapy |
| title | Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications |
| title_full | Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications |
| title_fullStr | Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications |
| title_full_unstemmed | Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications |
| title_short | Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications |
| title_sort | extracellular vesicles in lung cancer metastasis and their clinical applications |
| topic | extracellular vesicles metastasis lung cancer non-coding RNA therapy |
| url | https://www.mdpi.com/2072-6694/13/22/5633 |
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