Expression of serum inflammatory cytokines and oxidative stress markers and their correlation with coronary artery calcium score in patients with coronary heart disease
Introduction The present study was conducted to explore the expression of serum inflammatory cytokines and oxidative stress markers in patients with coronary heart disease (CHD), with an attempt to analyze their relationship with the coronary artery calcium score (CACS) by coronary computed tomograp...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2020-11-01
|
| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Expression-of-serum-inflammatory-cytokines-and-oxidative-stress-markers-and-their,128126,0,2.html |
| _version_ | 1797435450204356608 |
|---|---|
| author | Jia-Qi Yao Zhuo-Jun Deng Ming-Xing Fang Na Xiao Qing-Sheng Huang Yu Han Xuan Wu Cai-Zhe Ci Ke Chen Xiao-Yong Geng |
| author_facet | Jia-Qi Yao Zhuo-Jun Deng Ming-Xing Fang Na Xiao Qing-Sheng Huang Yu Han Xuan Wu Cai-Zhe Ci Ke Chen Xiao-Yong Geng |
| author_sort | Jia-Qi Yao |
| collection | DOAJ |
| description | Introduction
The present study was conducted to explore the expression of serum inflammatory cytokines and oxidative stress markers in patients with coronary heart disease (CHD), with an attempt to analyze their relationship with the coronary artery calcium score (CACS) by coronary computed tomography angiography (CCTA).
Material and methods
It total 81 patients with coronary heart disease and 81 healthy adults were included as the observation group and the control group, respectively. The levels of serum interleukin (IL)-6 and IL-12 of the two groups were detected by ELISA, and serum superoxide dismutase (SOD) was detected by the hydroxylamine oxidation method. Micro-RNA-497-5p (miR-497-5p) was screened out as a possible new CHD biomarker and its serum level was measured by real-time fluorescence quantitative PCR. The CACS of patients in the observation group was calculated by the Agatston method to analyze the correlation between the abovementioned indexes and CACS.
Results
With increase in the number of CHD lesions, the levels of IL-6, IL-12 and miR-497-5p rose gradually while the level of SOD decreased gradually. In the observation group, IL-6, IL-12 and miR-497-5p were positively correlated with CACS while SOD was negatively correlated with CACS.
Conclusions
Abnormal expression levels of serum IL-6, IL-12, SOD and miR-497-5p may be able to reveal the severity of the disease, and the combination with CACS is of potential value in terms of evaluating the condition of patients harboring coronary heart disease. |
| first_indexed | 2024-03-09T10:48:16Z |
| format | Article |
| id | doaj.art-4770ecceaec04c7f8d39a63019ad1160 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:48:16Z |
| publishDate | 2020-11-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-4770ecceaec04c7f8d39a63019ad11602023-12-01T09:46:10ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512020-11-011961709171310.5114/aoms.2020.101009128126Expression of serum inflammatory cytokines and oxidative stress markers and their correlation with coronary artery calcium score in patients with coronary heart diseaseJia-Qi Yao0Zhuo-Jun Deng1Ming-Xing Fang2Na Xiao3Qing-Sheng Huang4Yu Han5Xuan Wu6Cai-Zhe Ci7Ke Chen8Xiao-Yong Geng9Department of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of General Practice Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Critical Care Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Critical Care Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaIntroduction The present study was conducted to explore the expression of serum inflammatory cytokines and oxidative stress markers in patients with coronary heart disease (CHD), with an attempt to analyze their relationship with the coronary artery calcium score (CACS) by coronary computed tomography angiography (CCTA). Material and methods It total 81 patients with coronary heart disease and 81 healthy adults were included as the observation group and the control group, respectively. The levels of serum interleukin (IL)-6 and IL-12 of the two groups were detected by ELISA, and serum superoxide dismutase (SOD) was detected by the hydroxylamine oxidation method. Micro-RNA-497-5p (miR-497-5p) was screened out as a possible new CHD biomarker and its serum level was measured by real-time fluorescence quantitative PCR. The CACS of patients in the observation group was calculated by the Agatston method to analyze the correlation between the abovementioned indexes and CACS. Results With increase in the number of CHD lesions, the levels of IL-6, IL-12 and miR-497-5p rose gradually while the level of SOD decreased gradually. In the observation group, IL-6, IL-12 and miR-497-5p were positively correlated with CACS while SOD was negatively correlated with CACS. Conclusions Abnormal expression levels of serum IL-6, IL-12, SOD and miR-497-5p may be able to reveal the severity of the disease, and the combination with CACS is of potential value in terms of evaluating the condition of patients harboring coronary heart disease.https://www.archivesofmedicalscience.com/Expression-of-serum-inflammatory-cytokines-and-oxidative-stress-markers-and-their,128126,0,2.htmlcoronary heart diseasecacsinflammatory mediatorssuperoxide dismutasemicro rna-497-5p |
| spellingShingle | Jia-Qi Yao Zhuo-Jun Deng Ming-Xing Fang Na Xiao Qing-Sheng Huang Yu Han Xuan Wu Cai-Zhe Ci Ke Chen Xiao-Yong Geng Expression of serum inflammatory cytokines and oxidative stress markers and their correlation with coronary artery calcium score in patients with coronary heart disease Archives of Medical Science coronary heart disease cacs inflammatory mediators superoxide dismutase micro rna-497-5p |
| title | Expression of serum inflammatory cytokines and oxidative stress markers and their correlation with coronary artery calcium score in patients with coronary heart disease |
| title_full | Expression of serum inflammatory cytokines and oxidative stress markers and their correlation with coronary artery calcium score in patients with coronary heart disease |
| title_fullStr | Expression of serum inflammatory cytokines and oxidative stress markers and their correlation with coronary artery calcium score in patients with coronary heart disease |
| title_full_unstemmed | Expression of serum inflammatory cytokines and oxidative stress markers and their correlation with coronary artery calcium score in patients with coronary heart disease |
| title_short | Expression of serum inflammatory cytokines and oxidative stress markers and their correlation with coronary artery calcium score in patients with coronary heart disease |
| title_sort | expression of serum inflammatory cytokines and oxidative stress markers and their correlation with coronary artery calcium score in patients with coronary heart disease |
| topic | coronary heart disease cacs inflammatory mediators superoxide dismutase micro rna-497-5p |
| url | https://www.archivesofmedicalscience.com/Expression-of-serum-inflammatory-cytokines-and-oxidative-stress-markers-and-their,128126,0,2.html |
| work_keys_str_mv | AT jiaqiyao expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease AT zhuojundeng expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease AT mingxingfang expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease AT naxiao expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease AT qingshenghuang expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease AT yuhan expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease AT xuanwu expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease AT caizheci expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease AT kechen expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease AT xiaoyonggeng expressionofseruminflammatorycytokinesandoxidativestressmarkersandtheircorrelationwithcoronaryarterycalciumscoreinpatientswithcoronaryheartdisease |