Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered Report describes the proposed replication plan of key exp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2014-12-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/04180 |
| _version_ | 1811201185035583488 |
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| author | Denise Chroscinski Darryl Sampey Alex Hewitt Reproducibility Project: Cancer Biology |
| author_facet | Denise Chroscinski Darryl Sampey Alex Hewitt Reproducibility Project: Cancer Biology |
| author_sort | Denise Chroscinski |
| collection | DOAJ |
| description | The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered Report describes the proposed replication plan of key experiments from ‘Melanoma genome sequencing reveals frequent PREX2 mutations’ by Berger and colleagues, published in Nature in 2012 (Berger et al., 2012). The key experiments that will be replicated are those reported in Figure 3B and Supplementary Figure S6. In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole-genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published by eLife. |
| first_indexed | 2024-04-12T02:17:47Z |
| format | Article |
| id | doaj.art-4771c1acd33945ebaf5acdb63dbf1ac8 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:17:47Z |
| publishDate | 2014-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-4771c1acd33945ebaf5acdb63dbf1ac82022-12-22T03:52:13ZengeLife Sciences Publications LtdeLife2050-084X2014-12-01310.7554/eLife.04180Registered report: Melanoma genome sequencing reveals frequent PREX2 mutationsDenise Chroscinski0Darryl Sampey1Alex Hewitt2Reproducibility Project: Cancer BiologyNoble Life Sciences, Gaithersburg, United StatesBioFactura, Frederick, United StatesDepartment of Clinical Genetics, University of Melbourne, Melbourne, AustraliaThe Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered Report describes the proposed replication plan of key experiments from ‘Melanoma genome sequencing reveals frequent PREX2 mutations’ by Berger and colleagues, published in Nature in 2012 (Berger et al., 2012). The key experiments that will be replicated are those reported in Figure 3B and Supplementary Figure S6. In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole-genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published by eLife.https://elifesciences.org/articles/04180Reproducibility Project: Cancer Biologymethodologymelanomacancer genomicdriver mutation |
| spellingShingle | Denise Chroscinski Darryl Sampey Alex Hewitt Reproducibility Project: Cancer Biology Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations eLife Reproducibility Project: Cancer Biology methodology melanoma cancer genomic driver mutation |
| title | Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations |
| title_full | Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations |
| title_fullStr | Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations |
| title_full_unstemmed | Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations |
| title_short | Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations |
| title_sort | registered report melanoma genome sequencing reveals frequent prex2 mutations |
| topic | Reproducibility Project: Cancer Biology methodology melanoma cancer genomic driver mutation |
| url | https://elifesciences.org/articles/04180 |
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