Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births
Background: Synthetic chemicals are increasingly being recognized for potential independent contributions to preterm birth (PTB) and low birth weight (LBW). Bisphenols, parabens, and triclosan are consumer product chemicals that act via similar mechanisms including estrogen, androgen, and thyroid di...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412023006517 |
| _version_ | 1827376934963642368 |
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| author | Leonardo Trasande Morgan E. Nelson Akram Alshawabkeh Emily S. Barrett Jessie P. Buckley Dana Dabelea Anne L. Dunlop Julie B. Herbstman John D. Meeker Mrudula Naidu Craig Newschaffer Amy M. Padula Megan E. Romano Douglas M. Ruden Sheela Sathyanarayana Susan L. Schantz Anne P. Starling Taylor Etzel Ghassan B. Hamra |
| author_facet | Leonardo Trasande Morgan E. Nelson Akram Alshawabkeh Emily S. Barrett Jessie P. Buckley Dana Dabelea Anne L. Dunlop Julie B. Herbstman John D. Meeker Mrudula Naidu Craig Newschaffer Amy M. Padula Megan E. Romano Douglas M. Ruden Sheela Sathyanarayana Susan L. Schantz Anne P. Starling Taylor Etzel Ghassan B. Hamra |
| author_sort | Leonardo Trasande |
| collection | DOAJ |
| description | Background: Synthetic chemicals are increasingly being recognized for potential independent contributions to preterm birth (PTB) and low birth weight (LBW). Bisphenols, parabens, and triclosan are consumer product chemicals that act via similar mechanisms including estrogen, androgen, and thyroid disruption and oxidative stress. Multiple cohort studies have endeavored to examine effects on birth outcomes, and systematic reviews have been limited due to measurement of 1–2 spot samples during pregnancy and limited diversity of populations. Objective: To study the effects of prenatal phenols and parabens on birth size and gestational age (GA) in 3,619 mother-infant pairs from 11 cohorts in the NIH Environmental influences on Child Health Outcomes program. Results: While many associations were modest and statistically imprecise, a 1-unit increase in log10 pregnancy averaged concentration of benzophenone-3 and methylparaben were associated with decreases in birthweight, birthweight adjusted for gestational age and SGA. Increases in the odds of being SGA were 29% (95% CI: 5%, 58%) and 32% (95% CI: 3%, 70%), respectively. Bisphenol S in third trimester was also associated with SGA (OR 1.52, 95% CI 1.08, 2.13). Associations of benzophenone-3 and methylparaben with PTB and LBW were null. In addition, a 1-unit increase in log10 pregnancy averaged concentration of 2,4-dichlorophenol was associated with 43% lower (95% CI: −67%, −2%) odds of low birthweight; the direction of effect was the same for the highly correlated 2,5-dichlorophenol, but with a smaller magnitude (-29%, 95% CI: −53%, 8%). Discussion: In a large and diverse sample generally representative of the United States, benzophenone-3 and methylparaben were associated with lower birthweight as well as birthweight adjusted for gestational age and higher odds of SGA, while 2,4-dichlorophenol. These associations with smaller size at birth are concerning in light of the known consequences of intrauterine growth restriction for multiple important health outcomes emerging later in life. |
| first_indexed | 2024-03-08T12:30:05Z |
| format | Article |
| id | doaj.art-47730cbe04e94eb49cfb2e2e58ecf3f1 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-03-08T12:30:05Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-47730cbe04e94eb49cfb2e2e58ecf3f12024-01-22T04:15:25ZengElsevierEnvironment International0160-41202024-01-01183108378Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. BirthsLeonardo Trasande0Morgan E. Nelson1Akram Alshawabkeh2Emily S. Barrett3Jessie P. Buckley4Dana Dabelea5Anne L. Dunlop6Julie B. Herbstman7John D. Meeker8Mrudula Naidu9Craig Newschaffer10Amy M. Padula11Megan E. Romano12Douglas M. Ruden13Sheela Sathyanarayana14Susan L. Schantz15Anne P. Starling16Taylor Etzel17Ghassan B. Hamra18Department of Pediatrics, Division of Environmental Pediatrics, NYU Grossman School of Medicine, New York, NY, USA; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA; NYU Wagner School of Public Service, New York, NY, USA; Corresponding author at: Department of Pediatrics, New York University School of Medicine, 227 East 30th Street Rm 807, New York, NY 10016, USA.RTI International, Research Triangle Park, NC, USANortheastern University, Boston, MA, USADepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Environmental and Occupational Health Sciences Institute, Piscataway, NJ, USADepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USALifecourse Epidemiology Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USADepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USADepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USADepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USADepartment of Pediatrics, Division of Environmental Pediatrics, NYU Grossman School of Medicine, New York, NY, USACollege of Human Health and Development, Penn State University, Hershey, PA, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USADepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USADepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201Seattle Children’s Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USABeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, ILLifecourse Epidemiology Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USABackground: Synthetic chemicals are increasingly being recognized for potential independent contributions to preterm birth (PTB) and low birth weight (LBW). Bisphenols, parabens, and triclosan are consumer product chemicals that act via similar mechanisms including estrogen, androgen, and thyroid disruption and oxidative stress. Multiple cohort studies have endeavored to examine effects on birth outcomes, and systematic reviews have been limited due to measurement of 1–2 spot samples during pregnancy and limited diversity of populations. Objective: To study the effects of prenatal phenols and parabens on birth size and gestational age (GA) in 3,619 mother-infant pairs from 11 cohorts in the NIH Environmental influences on Child Health Outcomes program. Results: While many associations were modest and statistically imprecise, a 1-unit increase in log10 pregnancy averaged concentration of benzophenone-3 and methylparaben were associated with decreases in birthweight, birthweight adjusted for gestational age and SGA. Increases in the odds of being SGA were 29% (95% CI: 5%, 58%) and 32% (95% CI: 3%, 70%), respectively. Bisphenol S in third trimester was also associated with SGA (OR 1.52, 95% CI 1.08, 2.13). Associations of benzophenone-3 and methylparaben with PTB and LBW were null. In addition, a 1-unit increase in log10 pregnancy averaged concentration of 2,4-dichlorophenol was associated with 43% lower (95% CI: −67%, −2%) odds of low birthweight; the direction of effect was the same for the highly correlated 2,5-dichlorophenol, but with a smaller magnitude (-29%, 95% CI: −53%, 8%). Discussion: In a large and diverse sample generally representative of the United States, benzophenone-3 and methylparaben were associated with lower birthweight as well as birthweight adjusted for gestational age and higher odds of SGA, while 2,4-dichlorophenol. These associations with smaller size at birth are concerning in light of the known consequences of intrauterine growth restriction for multiple important health outcomes emerging later in life.http://www.sciencedirect.com/science/article/pii/S0160412023006517 |
| spellingShingle | Leonardo Trasande Morgan E. Nelson Akram Alshawabkeh Emily S. Barrett Jessie P. Buckley Dana Dabelea Anne L. Dunlop Julie B. Herbstman John D. Meeker Mrudula Naidu Craig Newschaffer Amy M. Padula Megan E. Romano Douglas M. Ruden Sheela Sathyanarayana Susan L. Schantz Anne P. Starling Taylor Etzel Ghassan B. Hamra Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births Environment International |
| title | Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births |
| title_full | Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births |
| title_fullStr | Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births |
| title_full_unstemmed | Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births |
| title_short | Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births |
| title_sort | prenatal phenol and paraben exposures and adverse birth outcomes a prospective analysis of u s births |
| url | http://www.sciencedirect.com/science/article/pii/S0160412023006517 |
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