Insulin resistance improvement and serum metabolomics of Hibiscus esulentus L. in patients with impaired glucose tolerance
Background/Aim. Prediabetes (PD) refers to the condition in which the blood sugar level is higher than normal but has not reached the diagnostic criteria for diabetes mellitus (DM) yet. Impaired glucose tolerance (IGT) is a major prediabetic symptom since most patients with type 2 DM have progressed...
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Military Health Department, Ministry of Defance, Serbia
2023-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502200040C.pdf |
| _version_ | 1797807508672217088 |
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| author | Chen Lin Wang Qi Sha Wenjun Zhang Cuiping Shen Tian Ming Lu Lei Tao |
| author_facet | Chen Lin Wang Qi Sha Wenjun Zhang Cuiping Shen Tian Ming Lu Lei Tao |
| author_sort | Chen Lin |
| collection | DOAJ |
| description | Background/Aim. Prediabetes (PD) refers to the condition in which the blood sugar level is higher than normal but has not reached the diagnostic criteria for diabetes mellitus (DM) yet. Impaired glucose tolerance (IGT) is a major prediabetic symptom since most patients with type 2 DM have progressed from the previous PD phase. The aim of the study was to observe the changes in serum metabolomics in patients with IGT treated with Hibiscus esculentus L. (H. esculentus) combined with the change of lifestyle. Methods. Sixty patients with IGT were divided into two groups. In one group, the subjects made a life-style change (LC group, simple diet control), and the other group of subjects made a lifestyle change combined with H. esculentus (LCH group) treatment with daily consumption of 20 g of dried H. esculentus fruit tea. The aim was to compare the blood glucose, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, and serum metabolomics after a 60-day clinical observation period. Results. There was no statistical significance in the glucose level between the two groups by the end of the observation period. The HOMA-IR index in the LCH group was lower than in the LC group (1.7 ± 1.1 vs. 2.4 ± 1.2, p = 0.030). Serum metabolomics revealed that the levels of d-galactose, d-glucose, turanose, and uric acid in the LCH group were significantly lower than those in the LC group (16.7 ± 3.9 mmol/L vs. 21.2 ±2.9 mmol/L, 101.5 ± 40.2 mmol/L vs. 132.9 ± 36.7 mmol/L, 1.8 ± 1.6 mmol/L vs. 3.76 ± 2.46 mmol/L, 44.56 ± 15.7 μmol/L vs. 67.8 ± 23.5 μmol /L, respectively). The levels of lactic acid and conjugated linoleic acid in the LCH group were significantly higher than those in the LC group (3.3 ± 0.5 mmol/L vs. 2.3 ± 0.8 mmol/L, 6.9 ± 6.1 mmol/L vs. 2.1 ± 1.2 mmol/L, respectively). Conclusion. H. esculentus, combined with a change of lifestyle, can reduce insulin resistance and the levels of multiple monosaccharides and blood uric acid in IGT patients. Regulation of the metabolism of lactic acid and conjugated linoleic acid may be the potential mechanism of how H. esculentus reduces insulin resistance. |
| first_indexed | 2024-03-13T06:23:33Z |
| format | Article |
| id | doaj.art-477543f5fca046d4859c247f7d194960 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-03-13T06:23:33Z |
| publishDate | 2023-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
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| series | Vojnosanitetski Pregled |
| spelling | doaj.art-477543f5fca046d4859c247f7d1949602023-06-09T10:44:51ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202023-01-0180323524210.2298/VSP210406040C0042-84502200040CInsulin resistance improvement and serum metabolomics of Hibiscus esulentus L. in patients with impaired glucose toleranceChen Lin0Wang Qi1Sha Wenjun2Zhang Cuiping3Shen Tian4Ming Lu5Lei Tao6Shanghai University of Traditional Chinese Medicine, Putuo Hospital, Department of Endocrinology, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Putuo Hospital, Department of Endocrinology, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Putuo Hospital, Department of Endocrinology, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Putuo Hospital, Department of Endocrinology, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Putuo Hospital, Department of Endocrinology, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Putuo Hospital, Department of Endocrinology, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Putuo Hospital, Department of Endocrinology, Shanghai, ChinaBackground/Aim. Prediabetes (PD) refers to the condition in which the blood sugar level is higher than normal but has not reached the diagnostic criteria for diabetes mellitus (DM) yet. Impaired glucose tolerance (IGT) is a major prediabetic symptom since most patients with type 2 DM have progressed from the previous PD phase. The aim of the study was to observe the changes in serum metabolomics in patients with IGT treated with Hibiscus esculentus L. (H. esculentus) combined with the change of lifestyle. Methods. Sixty patients with IGT were divided into two groups. In one group, the subjects made a life-style change (LC group, simple diet control), and the other group of subjects made a lifestyle change combined with H. esculentus (LCH group) treatment with daily consumption of 20 g of dried H. esculentus fruit tea. The aim was to compare the blood glucose, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, and serum metabolomics after a 60-day clinical observation period. Results. There was no statistical significance in the glucose level between the two groups by the end of the observation period. The HOMA-IR index in the LCH group was lower than in the LC group (1.7 ± 1.1 vs. 2.4 ± 1.2, p = 0.030). Serum metabolomics revealed that the levels of d-galactose, d-glucose, turanose, and uric acid in the LCH group were significantly lower than those in the LC group (16.7 ± 3.9 mmol/L vs. 21.2 ±2.9 mmol/L, 101.5 ± 40.2 mmol/L vs. 132.9 ± 36.7 mmol/L, 1.8 ± 1.6 mmol/L vs. 3.76 ± 2.46 mmol/L, 44.56 ± 15.7 μmol/L vs. 67.8 ± 23.5 μmol /L, respectively). The levels of lactic acid and conjugated linoleic acid in the LCH group were significantly higher than those in the LC group (3.3 ± 0.5 mmol/L vs. 2.3 ± 0.8 mmol/L, 6.9 ± 6.1 mmol/L vs. 2.1 ± 1.2 mmol/L, respectively). Conclusion. H. esculentus, combined with a change of lifestyle, can reduce insulin resistance and the levels of multiple monosaccharides and blood uric acid in IGT patients. Regulation of the metabolism of lactic acid and conjugated linoleic acid may be the potential mechanism of how H. esculentus reduces insulin resistance.https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502200040C.pdfglucose intoleranceinsulin resistancelife stylemetabolomicsplants, medicinalprediabetic stateserum |
| spellingShingle | Chen Lin Wang Qi Sha Wenjun Zhang Cuiping Shen Tian Ming Lu Lei Tao Insulin resistance improvement and serum metabolomics of Hibiscus esulentus L. in patients with impaired glucose tolerance Vojnosanitetski Pregled glucose intolerance insulin resistance life style metabolomics plants, medicinal prediabetic state serum |
| title | Insulin resistance improvement and serum metabolomics of Hibiscus esulentus L. in patients with impaired glucose tolerance |
| title_full | Insulin resistance improvement and serum metabolomics of Hibiscus esulentus L. in patients with impaired glucose tolerance |
| title_fullStr | Insulin resistance improvement and serum metabolomics of Hibiscus esulentus L. in patients with impaired glucose tolerance |
| title_full_unstemmed | Insulin resistance improvement and serum metabolomics of Hibiscus esulentus L. in patients with impaired glucose tolerance |
| title_short | Insulin resistance improvement and serum metabolomics of Hibiscus esulentus L. in patients with impaired glucose tolerance |
| title_sort | insulin resistance improvement and serum metabolomics of hibiscus esulentus l in patients with impaired glucose tolerance |
| topic | glucose intolerance insulin resistance life style metabolomics plants, medicinal prediabetic state serum |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502200040C.pdf |
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