Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?
Abstract Background Ultrasonography is commonly used to diagnose left ventricular noncompaction (LVNC). A ratio of noncompacted to compacted myocardium (NC/C ratio) > >2 is often used to diagnose LVNC. However, a large proportion of patients with noncompact myocardium have NC/C < 2, and the...
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | BMC Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12887-020-02312-5 |
| _version_ | 1828848404588920832 |
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| author | Yi Gan Li Luo Jie Tian Lingjuan Liu Tiewei Lu |
| author_facet | Yi Gan Li Luo Jie Tian Lingjuan Liu Tiewei Lu |
| author_sort | Yi Gan |
| collection | DOAJ |
| description | Abstract Background Ultrasonography is commonly used to diagnose left ventricular noncompaction (LVNC). A ratio of noncompacted to compacted myocardium (NC/C ratio) > >2 is often used to diagnose LVNC. However, a large proportion of patients with noncompact myocardium have NC/C < 2, and the prognosis of these patients have not been studied. Methods We included children diagnosed with LVNC between 0 and 15 years of age from January 2007 to December 2018. LVNC was diagnosed based on Stöllberger standard when over three trabeculae were found to be associated with the interventricular recesses. A maximal end systolic ratio of noncompacted to compacted layers was NC/C ratio. Outcomes for LVNC subjects with NC/C < 2 and NC/C > 2 were compared using Kaplan-Meier methods. Results There were 124 newly diagnosed LVNC cases, classified as isolated (i-LVNC, n = 47) or non-isolated (ni-LVNC, n = 77) LVNC and NC/C > 2 (n = 43) or < 2 (n = 81). The median (interquartile range) follow-up duration was 12 (3–30) months for all patients and 16 (6–36) months for survivors. Sixteen patients with i-LVNC died during follow-up. Patients with i-LVNC and NC/C > 2 had worse survival than those with NC/C < 2 (p = 0.022). Conclusions In conclusion, during a 12-month follow-up, patients with i-LVNC with NC/C < 2 had a benign prognosis and better outcomes than those with NC/C > 2, suggesting that the former could have a more active and routine lifestyle. |
| first_indexed | 2024-12-12T22:28:27Z |
| format | Article |
| id | doaj.art-4776669c11a14e0b9b1eb1965e2b3d9c |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-12T22:28:27Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-4776669c11a14e0b9b1eb1965e2b3d9c2022-12-22T00:09:40ZengBMCBMC Pediatrics1471-24312020-09-012011810.1186/s12887-020-02312-5Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?Yi Gan0Li Luo1Jie Tian2Lingjuan Liu3Tiewei Lu4Department of Cardiology; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders, Children’s Hospital of Chongqing Medical UniversityMinistry of Education Key Laboratory of Child Development and DisordersDepartment of Cardiology; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders, Children’s Hospital of Chongqing Medical UniversityDepartment of Cardiology; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders, Children’s Hospital of Chongqing Medical UniversityDepartment of Cardiology; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders, Children’s Hospital of Chongqing Medical UniversityAbstract Background Ultrasonography is commonly used to diagnose left ventricular noncompaction (LVNC). A ratio of noncompacted to compacted myocardium (NC/C ratio) > >2 is often used to diagnose LVNC. However, a large proportion of patients with noncompact myocardium have NC/C < 2, and the prognosis of these patients have not been studied. Methods We included children diagnosed with LVNC between 0 and 15 years of age from January 2007 to December 2018. LVNC was diagnosed based on Stöllberger standard when over three trabeculae were found to be associated with the interventricular recesses. A maximal end systolic ratio of noncompacted to compacted layers was NC/C ratio. Outcomes for LVNC subjects with NC/C < 2 and NC/C > 2 were compared using Kaplan-Meier methods. Results There were 124 newly diagnosed LVNC cases, classified as isolated (i-LVNC, n = 47) or non-isolated (ni-LVNC, n = 77) LVNC and NC/C > 2 (n = 43) or < 2 (n = 81). The median (interquartile range) follow-up duration was 12 (3–30) months for all patients and 16 (6–36) months for survivors. Sixteen patients with i-LVNC died during follow-up. Patients with i-LVNC and NC/C > 2 had worse survival than those with NC/C < 2 (p = 0.022). Conclusions In conclusion, during a 12-month follow-up, patients with i-LVNC with NC/C < 2 had a benign prognosis and better outcomes than those with NC/C > 2, suggesting that the former could have a more active and routine lifestyle.http://link.springer.com/article/10.1186/s12887-020-02312-5CardiomyopathyNoncompaction-to-compaction ratioLeft ventricular noncompaction |
| spellingShingle | Yi Gan Li Luo Jie Tian Lingjuan Liu Tiewei Lu Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis? BMC Pediatrics Cardiomyopathy Noncompaction-to-compaction ratio Left ventricular noncompaction |
| title | Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis? |
| title_full | Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis? |
| title_fullStr | Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis? |
| title_full_unstemmed | Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis? |
| title_short | Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis? |
| title_sort | do children with left ventricular noncompaction and a noncompaction to compaction ratio 2 have a better prognosis |
| topic | Cardiomyopathy Noncompaction-to-compaction ratio Left ventricular noncompaction |
| url | http://link.springer.com/article/10.1186/s12887-020-02312-5 |
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