Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum
Culturing fresh clinical isolates of P. falciparum and using the isotopic method, we tested separately chloroquine and isradipine – a calcium channel blocker –, and also the combination isradipine plus chloroquine. Tested wild isolates were chloroquinesensitive. With regard to the combination isradi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2005-06-01
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| Series: | Parasite |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1051/parasite/2005122187 |
| _version_ | 1827776637470507008 |
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| author | Randrianarivelojosia M. Jambou R. |
| author_facet | Randrianarivelojosia M. Jambou R. |
| author_sort | Randrianarivelojosia M. |
| collection | DOAJ |
| description | Culturing fresh clinical isolates of P. falciparum and using the isotopic method, we tested separately chloroquine and isradipine – a calcium channel blocker –, and also the combination isradipine plus chloroquine. Tested wild isolates were chloroquinesensitive. With regard to the combination isradipine/chloroquine, the isobolograms obtained indicate that isradipine antagonises chloroquine antiplasmodial activity. Taking into account these findings, we discuss the issues related to the calcium channel blocker molecules. |
| first_indexed | 2024-03-11T14:08:05Z |
| format | Article |
| id | doaj.art-47771ded3fb044888c7f6e284d037f28 |
| institution | Directory Open Access Journal |
| issn | 1252-607X 1776-1042 |
| language | English |
| last_indexed | 2024-03-11T14:08:05Z |
| publishDate | 2005-06-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-47771ded3fb044888c7f6e284d037f282023-11-02T01:04:12ZengEDP SciencesParasite1252-607X1776-10422005-06-0112218718910.1051/parasite/2005122187parasite2005122p187Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparumRandrianarivelojosia M.Jambou R.Culturing fresh clinical isolates of P. falciparum and using the isotopic method, we tested separately chloroquine and isradipine – a calcium channel blocker –, and also the combination isradipine plus chloroquine. Tested wild isolates were chloroquinesensitive. With regard to the combination isradipine/chloroquine, the isobolograms obtained indicate that isradipine antagonises chloroquine antiplasmodial activity. Taking into account these findings, we discuss the issues related to the calcium channel blocker molecules.http://dx.doi.org/10.1051/parasite/2005122187chloroquineisradipinePlasmodium falciparumMadagascar |
| spellingShingle | Randrianarivelojosia M. Jambou R. Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum Parasite chloroquine isradipine Plasmodium falciparum Madagascar |
| title | Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum |
| title_full | Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum |
| title_fullStr | Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum |
| title_full_unstemmed | Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum |
| title_short | Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum |
| title_sort | isradipine a calcium channel blocker does not potentiate chloroquine antiplasmodial activity against plasmodium falciparum |
| topic | chloroquine isradipine Plasmodium falciparum Madagascar |
| url | http://dx.doi.org/10.1051/parasite/2005122187 |
| work_keys_str_mv | AT randrianarivelojosiam isradipineacalciumchannelblockerdoesnotpotentiatechloroquineantiplasmodialactivityagainstplasmodiumfalciparum AT jambour isradipineacalciumchannelblockerdoesnotpotentiatechloroquineantiplasmodialactivityagainstplasmodiumfalciparum |