Perivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potential
This review is devoted to the analysis of data on the study of the endocrine function of perivascular adipose tissue (PVAT), its role in the synthesis and secretion of adipocyte hormones – adipokines (leptin, adiponectin, resistin). The results of studies on the possible systemic and local effects o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2020-06-01
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| Series: | Атеросклероз |
| Subjects: | |
| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/377/363 |
| _version_ | 1797964386319466496 |
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| author | D. A. Borodkina O. V. Gruzdeva E. V. Belik Yu. A. Dyleva E. I. Palicheva |
| author_facet | D. A. Borodkina O. V. Gruzdeva E. V. Belik Yu. A. Dyleva E. I. Palicheva |
| author_sort | D. A. Borodkina |
| collection | DOAJ |
| description | This review is devoted to the analysis of data on the study of the endocrine function of perivascular adipose tissue (PVAT), its role in the synthesis and secretion of adipocyte hormones – adipokines (leptin, adiponectin, resistin). The results of studies on the possible systemic and local effects of PVAT are reflected. Demonstrated data on the phenotypic affiliation of PVAT, the features of its endocrine and paracrine functions. Pro-and anti-inflammatory agents secreted by PVAT affect vascular health and are involved in the pathogenetic mechanisms of the development of atherosclerosis. This review summarizes current evidence that PVAT refers to special types of adipose tissue, in terms of both functionality, origin, and role in the development of cardiovascular diseases caused by obesity. In general, PVAT can be considered as a promising pharmacological target for the prevention of cardiovascular risks associated with these diseases. |
| first_indexed | 2024-04-11T01:44:19Z |
| format | Article |
| id | doaj.art-477789f4ca9c48a78ee31bd170785b52 |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:44:19Z |
| publishDate | 2020-06-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-477789f4ca9c48a78ee31bd170785b522023-01-03T08:00:17ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2020-06-011626372https://doi.org/10.15372/ATER20200206Perivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potentialD. A. Borodkina0https://orcid.org/0000-0002-6221-3509O. V. Gruzdeva1https://orcid.org/0000-0002-7780-829XE. V. Belik2https://orcid.org/0000-0003-3996-3325Yu. A. Dyleva3https://orcid.org/0000-0002-6890-3287E. I. Palicheva4https://orcid.org/0000-0002-5642-7746Research Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationThis review is devoted to the analysis of data on the study of the endocrine function of perivascular adipose tissue (PVAT), its role in the synthesis and secretion of adipocyte hormones – adipokines (leptin, adiponectin, resistin). The results of studies on the possible systemic and local effects of PVAT are reflected. Demonstrated data on the phenotypic affiliation of PVAT, the features of its endocrine and paracrine functions. Pro-and anti-inflammatory agents secreted by PVAT affect vascular health and are involved in the pathogenetic mechanisms of the development of atherosclerosis. This review summarizes current evidence that PVAT refers to special types of adipose tissue, in terms of both functionality, origin, and role in the development of cardiovascular diseases caused by obesity. In general, PVAT can be considered as a promising pharmacological target for the prevention of cardiovascular risks associated with these diseases.https://ateroskleroz.elpub.ru/jour/article/view/377/363perivascular adipose tissuewhite adipose tissueinflammationcardiovascular disease |
| spellingShingle | D. A. Borodkina O. V. Gruzdeva E. V. Belik Yu. A. Dyleva E. I. Palicheva Perivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potential Атеросклероз perivascular adipose tissue white adipose tissue inflammation cardiovascular disease |
| title | Perivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potential |
| title_full | Perivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potential |
| title_fullStr | Perivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potential |
| title_full_unstemmed | Perivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potential |
| title_short | Perivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potential |
| title_sort | perivascular adipose tissue and atherosclerosis phenotypic features and therapeutic potential |
| topic | perivascular adipose tissue white adipose tissue inflammation cardiovascular disease |
| url | https://ateroskleroz.elpub.ru/jour/article/view/377/363 |
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