EXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSIS
The review describes main classes of extracellular microvesicular particles, mechanisms of their biogenesis and their potential role in the development of tuberculosis. Special attention is paid to apoptosis of macrophages infected with tuberculous mycobacteria, generation of apoptotic ectosome and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2019-02-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1219 |
| _version_ | 1826563041367425024 |
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| author | A. E. Petrenko Y. Sh. Shvartz S. N. Belogorodtsev |
| author_facet | A. E. Petrenko Y. Sh. Shvartz S. N. Belogorodtsev |
| author_sort | A. E. Petrenko |
| collection | DOAJ |
| description | The review describes main classes of extracellular microvesicular particles, mechanisms of their biogenesis and their potential role in the development of tuberculosis. Special attention is paid to apoptosis of macrophages infected with tuberculous mycobacteria, generation of apoptotic ectosome and involvement of the latter into the formation of anti-tuberculosis immune response. Conclusion: mechanisms of apoptotic blebbing, ectosomes and clearing of these particles possess the potential to become a new tool within pathogenetic therapy of tuberculosis. |
| first_indexed | 2024-03-12T04:56:35Z |
| format | Article |
| id | doaj.art-477886ca274f440cbbfbfa051fdd7c87 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2025-03-14T09:57:39Z |
| publishDate | 2019-02-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-477886ca274f440cbbfbfa051fdd7c872025-03-02T11:22:29ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062019-02-01971415110.21292/2075-1230-2019-97-1-41-511219EXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSISA. E. Petrenko0Y. Sh. Shvartz1S. N. Belogorodtsev2Novosibirsk Tuberculosis Research Institute; Novosibirsk State UniversityNovosibirsk Tuberculosis Research InstituteNovosibirsk Tuberculosis Research InstituteThe review describes main classes of extracellular microvesicular particles, mechanisms of their biogenesis and their potential role in the development of tuberculosis. Special attention is paid to apoptosis of macrophages infected with tuberculous mycobacteria, generation of apoptotic ectosome and involvement of the latter into the formation of anti-tuberculosis immune response. Conclusion: mechanisms of apoptotic blebbing, ectosomes and clearing of these particles possess the potential to become a new tool within pathogenetic therapy of tuberculosis.https://www.tibl-journal.com/jour/article/view/1219tuberculosisapoptosisapoptotic corpusclesectosomesexosomes |
| spellingShingle | A. E. Petrenko Y. Sh. Shvartz S. N. Belogorodtsev EXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSIS Туберкулез и болезни лёгких tuberculosis apoptosis apoptotic corpuscles ectosomes exosomes |
| title | EXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSIS |
| title_full | EXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSIS |
| title_fullStr | EXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSIS |
| title_full_unstemmed | EXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSIS |
| title_short | EXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSIS |
| title_sort | extracellular microvesicular particles in the pathogenesis of tuberculosis |
| topic | tuberculosis apoptosis apoptotic corpuscles ectosomes exosomes |
| url | https://www.tibl-journal.com/jour/article/view/1219 |
| work_keys_str_mv | AT aepetrenko extracellularmicrovesicularparticlesinthepathogenesisoftuberculosis AT yshshvartz extracellularmicrovesicularparticlesinthepathogenesisoftuberculosis AT snbelogorodtsev extracellularmicrovesicularparticlesinthepathogenesisoftuberculosis |