Oxidative injury and neuropathy in diabetes and impaired glucose tolerance
Clinical studies suggest that impaired glucose tolerance (IGT) is associated with the development of neuropathy. The aim of the current study was to determine if neuropathy developed in the female Zucker Diabetic Fatty (ZDF) rat, an animal model of IGT and type 2 diabetes. The ZDF rat develops impai...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2008-06-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996108000442 |
| _version_ | 1818414495848988672 |
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| author | James W. Russell Alison Berent-Spillson Andrea M. Vincent Catherine L. Freimann Kelli A. Sullivan Eva L. Feldman |
| author_facet | James W. Russell Alison Berent-Spillson Andrea M. Vincent Catherine L. Freimann Kelli A. Sullivan Eva L. Feldman |
| author_sort | James W. Russell |
| collection | DOAJ |
| description | Clinical studies suggest that impaired glucose tolerance (IGT) is associated with the development of neuropathy. The aim of the current study was to determine if neuropathy developed in the female Zucker Diabetic Fatty (ZDF) rat, an animal model of IGT and type 2 diabetes. The ZDF rat develops impaired glucose tolerance (IGT) when fed a control diet, and frank diabetes when fed a high fat diet. Following 10 weeks of hyperglycemia, sensory nerve action potentials (SNAP) and compound motor action potentials (CMAP) were reduced and sensory conduction velocities were slowed (distal>proximal) in the tail and hind limb in ZDF animals with IGT and frank diabetes (p<0.01). Neuropathy was coupled with evidence of increased reactive oxygen species (ROS) and cellular injury in dorsal root ganglion (DRG) neurons from IGT animals. Our study supports the hypothesis that neuropathy develops in an animal model of IGT and is associated with evidence of oxidative injury in DRG and peripheral nerves. |
| first_indexed | 2024-12-14T11:20:01Z |
| format | Article |
| id | doaj.art-4778db7415774218bf9c34c3866f817f |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-14T11:20:01Z |
| publishDate | 2008-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-4778db7415774218bf9c34c3866f817f2022-12-21T23:03:47ZengElsevierNeurobiology of Disease1095-953X2008-06-01303420429Oxidative injury and neuropathy in diabetes and impaired glucose toleranceJames W. Russell0Alison Berent-Spillson1Andrea M. Vincent2Catherine L. Freimann3Kelli A. Sullivan4Eva L. Feldman5Department of Neurology, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, USA; Department of Anatomy and Neurobiology, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, USA; Veterans Affairs Medical Center, Baltimore, MD, USA; Corresponding author. Fax: +1 410 706 4949.Molecular and Behavioral Neuroscience Institute, University of Michigan, USADepartment of Neurology, University of Michigan, USANovartis Pharmaceuticals, East Hanover, New Jersey, USADepartment of Neurology, University of Michigan, USADepartment of Neurology, University of Michigan, USAClinical studies suggest that impaired glucose tolerance (IGT) is associated with the development of neuropathy. The aim of the current study was to determine if neuropathy developed in the female Zucker Diabetic Fatty (ZDF) rat, an animal model of IGT and type 2 diabetes. The ZDF rat develops impaired glucose tolerance (IGT) when fed a control diet, and frank diabetes when fed a high fat diet. Following 10 weeks of hyperglycemia, sensory nerve action potentials (SNAP) and compound motor action potentials (CMAP) were reduced and sensory conduction velocities were slowed (distal>proximal) in the tail and hind limb in ZDF animals with IGT and frank diabetes (p<0.01). Neuropathy was coupled with evidence of increased reactive oxygen species (ROS) and cellular injury in dorsal root ganglion (DRG) neurons from IGT animals. Our study supports the hypothesis that neuropathy develops in an animal model of IGT and is associated with evidence of oxidative injury in DRG and peripheral nerves.http://www.sciencedirect.com/science/article/pii/S0969996108000442NeuropathyDiabetesImpaired glucose toleranceOxidative stressAxonsDorsal root ganglia |
| spellingShingle | James W. Russell Alison Berent-Spillson Andrea M. Vincent Catherine L. Freimann Kelli A. Sullivan Eva L. Feldman Oxidative injury and neuropathy in diabetes and impaired glucose tolerance Neurobiology of Disease Neuropathy Diabetes Impaired glucose tolerance Oxidative stress Axons Dorsal root ganglia |
| title | Oxidative injury and neuropathy in diabetes and impaired glucose tolerance |
| title_full | Oxidative injury and neuropathy in diabetes and impaired glucose tolerance |
| title_fullStr | Oxidative injury and neuropathy in diabetes and impaired glucose tolerance |
| title_full_unstemmed | Oxidative injury and neuropathy in diabetes and impaired glucose tolerance |
| title_short | Oxidative injury and neuropathy in diabetes and impaired glucose tolerance |
| title_sort | oxidative injury and neuropathy in diabetes and impaired glucose tolerance |
| topic | Neuropathy Diabetes Impaired glucose tolerance Oxidative stress Axons Dorsal root ganglia |
| url | http://www.sciencedirect.com/science/article/pii/S0969996108000442 |
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