Serum interleukin-18 and its relationship with subclinical atherosclerosis in systemic lupus erythematosus
BACKGROUND: Interleukin-18 (IL-18) is a pro-inflammatory and pro-atherogenic factor, and its blood level has shown a direct correlation with atherosclerosis. We aimed to evaluate the serum IL-18 level in patients with systemic lupus erythematosus (SLE) and its relationship with the intima-media thic...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Vesnu Publications
2022-01-01
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| Series: | ARYA Atherosclerosis |
| Subjects: | |
| Online Access: | https://arya.mui.ac.ir/article_10777_f8744bce04a985c76f51eea8d2ab8c88.pdf |
| _version_ | 1811154518126100480 |
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| author | Zahra Rezaieyazdi Mina AkbariRad Nayyereh Saadati Masoumeh Salari Reza Orang Sima Sedighi Habibollah Esmaily Mahmoud Reza Azarpazhooh Abdollah Firoozi Ensieh Akbarpour |
| author_facet | Zahra Rezaieyazdi Mina AkbariRad Nayyereh Saadati Masoumeh Salari Reza Orang Sima Sedighi Habibollah Esmaily Mahmoud Reza Azarpazhooh Abdollah Firoozi Ensieh Akbarpour |
| author_sort | Zahra Rezaieyazdi |
| collection | DOAJ |
| description | BACKGROUND: Interleukin-18 (IL-18) is a pro-inflammatory and pro-atherogenic factor, and its blood level has shown a direct correlation with atherosclerosis. We aimed to evaluate the serum IL-18 level in patients with systemic lupus erythematosus (SLE) and its relationship with the intima-media thickness (IMT) of the carotid artery in these patients, as an indicator of atherosclerosis.METHODS: In this cross-sectional study, 60 patients as the patient group and 30 healthy volunteers as the control group [matched sex, age, and body mass index (BMI)] were selected, and their disease status and general data were gathered using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) form. A blood sample was also obtained from all participants to determine the serum level of IL-18 and other metrics, including high-sensitivity C-reactive protein (hs-CRP), cholesterol, triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), anti-double stranded deoxyribonucleic acid (anti-dsDNA), complement 3 (C3), and C4. The IMT of the carotid artery was calculated in both groups. We also evaluated the clinical cardiovascular manifestations.RESULTS: The serum IL-18 levels in patients were significantly higher than in the control group (P ˂ 0.005). It had no significant correlation with disease activity (P = 0.10). The patients with SLE with high IL-18 serum levels (> 280 pg/ml) had higher SLEDAI-2K (P = 0.02) than the patients with a low level (< 280), where 280 was the median of the IL-18 levels. The serum IL-18 level had no significant correlation with the carotid artery IMT.CONCLUSION: A high level of IL-18 reflects the disease activity, but it was not significantly correlated with subclinical atherosclerosis, denoted by the carotid artery IMT. |
| first_indexed | 2024-04-10T04:18:06Z |
| format | Article |
| id | doaj.art-477aee8eb04d42b490bec4473ee5e3ec |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-04-10T04:18:06Z |
| publishDate | 2022-01-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-477aee8eb04d42b490bec4473ee5e3ec2023-03-11T12:59:30ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382022-01-01171212610.22122/arya.v17i0.212610777Serum interleukin-18 and its relationship with subclinical atherosclerosis in systemic lupus erythematosusZahra Rezaieyazdi0Mina AkbariRad1Nayyereh Saadati2Masoumeh Salari3Reza Orang4Sima Sedighi5Habibollah Esmaily6Mahmoud Reza Azarpazhooh7Abdollah Firoozi8Ensieh Akbarpour9Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, IranAssistant Professor, Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranRheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, IranRheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, IranRheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, IranGolestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, IranDepartment of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IranPharmacist, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Epidemiology and Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, IranBACKGROUND: Interleukin-18 (IL-18) is a pro-inflammatory and pro-atherogenic factor, and its blood level has shown a direct correlation with atherosclerosis. We aimed to evaluate the serum IL-18 level in patients with systemic lupus erythematosus (SLE) and its relationship with the intima-media thickness (IMT) of the carotid artery in these patients, as an indicator of atherosclerosis.METHODS: In this cross-sectional study, 60 patients as the patient group and 30 healthy volunteers as the control group [matched sex, age, and body mass index (BMI)] were selected, and their disease status and general data were gathered using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) form. A blood sample was also obtained from all participants to determine the serum level of IL-18 and other metrics, including high-sensitivity C-reactive protein (hs-CRP), cholesterol, triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), anti-double stranded deoxyribonucleic acid (anti-dsDNA), complement 3 (C3), and C4. The IMT of the carotid artery was calculated in both groups. We also evaluated the clinical cardiovascular manifestations.RESULTS: The serum IL-18 levels in patients were significantly higher than in the control group (P ˂ 0.005). It had no significant correlation with disease activity (P = 0.10). The patients with SLE with high IL-18 serum levels (> 280 pg/ml) had higher SLEDAI-2K (P = 0.02) than the patients with a low level (< 280), where 280 was the median of the IL-18 levels. The serum IL-18 level had no significant correlation with the carotid artery IMT.CONCLUSION: A high level of IL-18 reflects the disease activity, but it was not significantly correlated with subclinical atherosclerosis, denoted by the carotid artery IMT.https://arya.mui.ac.ir/article_10777_f8744bce04a985c76f51eea8d2ab8c88.pdfsystemic lupus erythematosusinterleukin18atherosclerosis |
| spellingShingle | Zahra Rezaieyazdi Mina AkbariRad Nayyereh Saadati Masoumeh Salari Reza Orang Sima Sedighi Habibollah Esmaily Mahmoud Reza Azarpazhooh Abdollah Firoozi Ensieh Akbarpour Serum interleukin-18 and its relationship with subclinical atherosclerosis in systemic lupus erythematosus ARYA Atherosclerosis systemic lupus erythematosus interleukin18 atherosclerosis |
| title | Serum interleukin-18 and its relationship with subclinical atherosclerosis in systemic lupus erythematosus |
| title_full | Serum interleukin-18 and its relationship with subclinical atherosclerosis in systemic lupus erythematosus |
| title_fullStr | Serum interleukin-18 and its relationship with subclinical atherosclerosis in systemic lupus erythematosus |
| title_full_unstemmed | Serum interleukin-18 and its relationship with subclinical atherosclerosis in systemic lupus erythematosus |
| title_short | Serum interleukin-18 and its relationship with subclinical atherosclerosis in systemic lupus erythematosus |
| title_sort | serum interleukin 18 and its relationship with subclinical atherosclerosis in systemic lupus erythematosus |
| topic | systemic lupus erythematosus interleukin18 atherosclerosis |
| url | https://arya.mui.ac.ir/article_10777_f8744bce04a985c76f51eea8d2ab8c88.pdf |
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