Weight at birth and subsequent fecundability: a prospective cohort study.
To examine the association between a woman's birth weight and her subsequent fecundability.In this prospective cohort study, we included 2,773 Danish pregnancy planners enrolled in the internet-based cohort study "Snart-Gravid", conducted during 2007-2012. Participants were 18-40 year...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3988145?pdf=render |
| _version_ | 1818508092941271040 |
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| author | Cathrine Wildenschild Anders H Riis Vera Ehrenstein Berit L Heitmann Elizabeth E Hatch Lauren A Wise Kenneth J Rothman Henrik T Sørensen Ellen M Mikkelsen |
| author_facet | Cathrine Wildenschild Anders H Riis Vera Ehrenstein Berit L Heitmann Elizabeth E Hatch Lauren A Wise Kenneth J Rothman Henrik T Sørensen Ellen M Mikkelsen |
| author_sort | Cathrine Wildenschild |
| collection | DOAJ |
| description | To examine the association between a woman's birth weight and her subsequent fecundability.In this prospective cohort study, we included 2,773 Danish pregnancy planners enrolled in the internet-based cohort study "Snart-Gravid", conducted during 2007-2012. Participants were 18-40 years old at study entry, attempting to conceive, and were not receiving fertility treatment. Data on weight at birth were obtained from the Danish Medical Birth Registry and categorized as <2,500 grams, 2,500-2,999 grams, 3,000-3,999 grams, and ≥ 4,000 grams. In additional analyses, birth weight was categorized according to z-scores for each gestational week at birth. Time-to-pregnancy measured in cycles was used to compute fecundability ratios (FR) and 95% confidence intervals (CI), using a proportional probabilities regression model.Relative to women with a birth weight of 3,000-3,999 grams, FRs adjusted for gestational age, year of birth, and maternal socio-demographic and medical factors were 0.99 (95% CI: 0.73;1.34), 0.99 (95% CI: 0.87;1.12), and 1.08 (95% CI: 0.94;1.24) for birth weight <2,500 grams, 2,500-2,999 grams, and ≥ 4,000 grams, respectively. Estimates remained unchanged after further adjustment for markers of the participant's mother's fecundability. We obtained similar results when we restricted to women who were born at term, and to women who had attempted to conceive for a maximum of 6 cycles before study entry. Results remained similar when we estimated FRs according to z-scores of birth weight.Our results indicate that birth weight appears not to be an important determinant of fecundability. |
| first_indexed | 2024-12-10T22:27:03Z |
| format | Article |
| id | doaj.art-477c8c97a623495c8b265fd4920e2fc0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T22:27:03Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-477c8c97a623495c8b265fd4920e2fc02022-12-22T01:31:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9525710.1371/journal.pone.0095257Weight at birth and subsequent fecundability: a prospective cohort study.Cathrine WildenschildAnders H RiisVera EhrensteinBerit L HeitmannElizabeth E HatchLauren A WiseKenneth J RothmanHenrik T SørensenEllen M MikkelsenTo examine the association between a woman's birth weight and her subsequent fecundability.In this prospective cohort study, we included 2,773 Danish pregnancy planners enrolled in the internet-based cohort study "Snart-Gravid", conducted during 2007-2012. Participants were 18-40 years old at study entry, attempting to conceive, and were not receiving fertility treatment. Data on weight at birth were obtained from the Danish Medical Birth Registry and categorized as <2,500 grams, 2,500-2,999 grams, 3,000-3,999 grams, and ≥ 4,000 grams. In additional analyses, birth weight was categorized according to z-scores for each gestational week at birth. Time-to-pregnancy measured in cycles was used to compute fecundability ratios (FR) and 95% confidence intervals (CI), using a proportional probabilities regression model.Relative to women with a birth weight of 3,000-3,999 grams, FRs adjusted for gestational age, year of birth, and maternal socio-demographic and medical factors were 0.99 (95% CI: 0.73;1.34), 0.99 (95% CI: 0.87;1.12), and 1.08 (95% CI: 0.94;1.24) for birth weight <2,500 grams, 2,500-2,999 grams, and ≥ 4,000 grams, respectively. Estimates remained unchanged after further adjustment for markers of the participant's mother's fecundability. We obtained similar results when we restricted to women who were born at term, and to women who had attempted to conceive for a maximum of 6 cycles before study entry. Results remained similar when we estimated FRs according to z-scores of birth weight.Our results indicate that birth weight appears not to be an important determinant of fecundability.http://europepmc.org/articles/PMC3988145?pdf=render |
| spellingShingle | Cathrine Wildenschild Anders H Riis Vera Ehrenstein Berit L Heitmann Elizabeth E Hatch Lauren A Wise Kenneth J Rothman Henrik T Sørensen Ellen M Mikkelsen Weight at birth and subsequent fecundability: a prospective cohort study. PLoS ONE |
| title | Weight at birth and subsequent fecundability: a prospective cohort study. |
| title_full | Weight at birth and subsequent fecundability: a prospective cohort study. |
| title_fullStr | Weight at birth and subsequent fecundability: a prospective cohort study. |
| title_full_unstemmed | Weight at birth and subsequent fecundability: a prospective cohort study. |
| title_short | Weight at birth and subsequent fecundability: a prospective cohort study. |
| title_sort | weight at birth and subsequent fecundability a prospective cohort study |
| url | http://europepmc.org/articles/PMC3988145?pdf=render |
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