Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility
Abstract Background Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that plays a crucial role in modulating the inflammatory response and activating the complement system. Additionally, plasma PTX3 has emerged as a potential biomarker for various infectious diseases. The aim of this stu...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08862-0 |
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| author | Ana Clara Cadidé Gonzaga Moraes Renata Clesia Feitosa Viana da Luz André Luís Magalhães Fernandes Milena Xavier Silva Barbosa Lorena Viana de Andrade Anderson da Costa Armstrong Carlos Dornels Freire de Souza Rodrigo Feliciano do Carmo |
| author_facet | Ana Clara Cadidé Gonzaga Moraes Renata Clesia Feitosa Viana da Luz André Luís Magalhães Fernandes Milena Xavier Silva Barbosa Lorena Viana de Andrade Anderson da Costa Armstrong Carlos Dornels Freire de Souza Rodrigo Feliciano do Carmo |
| author_sort | Ana Clara Cadidé Gonzaga Moraes |
| collection | DOAJ |
| description | Abstract Background Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that plays a crucial role in modulating the inflammatory response and activating the complement system. Additionally, plasma PTX3 has emerged as a potential biomarker for various infectious diseases. The aim of this study was to evaluate the association of PTX3 gene polymorphisms and PTX3 plasma levels with susceptibility to leprosy and clinical characteristics. Methods Patients with leprosy from a hyperendemic area in the Northeast Region of Brazil were included. Healthy household contacts and healthy blood donors from the same geographical area were recruited as a control group. The rs1840680 and rs2305619 polymorphisms of PTX3 were determined by real-time PCR. Plasma levels of PTX3 were determined by ELISA. Results A total of 512 individuals were included. Of these, 273 were patients diagnosed with leprosy; 53 were household contacts, and 186 were healthy blood donors. No association was observed between PTX3 polymorphisms and susceptibility to leprosy or development of leprosy reaction or physical disability. On the other hand, plasma levels of PTX3 were significantly higher in patients with leprosy when compared to household contacts (p = 0.003) or blood donors (p = 0.04). It was also observed that PTX3 levels drop significantly after multidrug therapy (p < 0.0001). Conclusions Our results suggest that PTX3 may play an important role in the pathogenesis of leprosy and point to the potential use of this molecule as an infection marker. |
| first_indexed | 2024-03-09T01:21:20Z |
| format | Article |
| id | doaj.art-477eb917f137496f984713fb67f49dae |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-09T01:21:20Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-477eb917f137496f984713fb67f49dae2023-12-10T12:08:57ZengBMCBMC Infectious Diseases1471-23342023-12-012311710.1186/s12879-023-08862-0Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibilityAna Clara Cadidé Gonzaga Moraes0Renata Clesia Feitosa Viana da Luz1André Luís Magalhães Fernandes2Milena Xavier Silva Barbosa3Lorena Viana de Andrade4Anderson da Costa Armstrong5Carlos Dornels Freire de Souza6Rodrigo Feliciano do Carmo7Postgraduate Program in Health and Biological Sciences, Federal University of the São Francisco Valley (UNIVASF)Postgraduate Program in Health and Biological Sciences, Federal University of the São Francisco Valley (UNIVASF)Foundation of Hematology and Hemotherapy of Bahia (HEMOBA)Postgraduate Program in Biosciences, Federal University of the São Francisco Valley (UNIVASF)Postgraduate Program in Biosciences, Federal University of the São Francisco Valley (UNIVASF)College of Medicine, Federal University of the São Francisco Valley (UNIVASF)College of Medicine, Federal University of the São Francisco Valley (UNIVASF)Postgraduate Program in Health and Biological Sciences, Federal University of the São Francisco Valley (UNIVASF)Abstract Background Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that plays a crucial role in modulating the inflammatory response and activating the complement system. Additionally, plasma PTX3 has emerged as a potential biomarker for various infectious diseases. The aim of this study was to evaluate the association of PTX3 gene polymorphisms and PTX3 plasma levels with susceptibility to leprosy and clinical characteristics. Methods Patients with leprosy from a hyperendemic area in the Northeast Region of Brazil were included. Healthy household contacts and healthy blood donors from the same geographical area were recruited as a control group. The rs1840680 and rs2305619 polymorphisms of PTX3 were determined by real-time PCR. Plasma levels of PTX3 were determined by ELISA. Results A total of 512 individuals were included. Of these, 273 were patients diagnosed with leprosy; 53 were household contacts, and 186 were healthy blood donors. No association was observed between PTX3 polymorphisms and susceptibility to leprosy or development of leprosy reaction or physical disability. On the other hand, plasma levels of PTX3 were significantly higher in patients with leprosy when compared to household contacts (p = 0.003) or blood donors (p = 0.04). It was also observed that PTX3 levels drop significantly after multidrug therapy (p < 0.0001). Conclusions Our results suggest that PTX3 may play an important role in the pathogenesis of leprosy and point to the potential use of this molecule as an infection marker.https://doi.org/10.1186/s12879-023-08862-0BiomarkersLeprosyPentraxinPolymorphismSNP |
| spellingShingle | Ana Clara Cadidé Gonzaga Moraes Renata Clesia Feitosa Viana da Luz André Luís Magalhães Fernandes Milena Xavier Silva Barbosa Lorena Viana de Andrade Anderson da Costa Armstrong Carlos Dornels Freire de Souza Rodrigo Feliciano do Carmo Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility BMC Infectious Diseases Biomarkers Leprosy Pentraxin Polymorphism SNP |
| title | Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility |
| title_full | Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility |
| title_fullStr | Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility |
| title_full_unstemmed | Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility |
| title_short | Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility |
| title_sort | association of ptx3 gene polymorphisms and ptx3 plasma levels with leprosy susceptibility |
| topic | Biomarkers Leprosy Pentraxin Polymorphism SNP |
| url | https://doi.org/10.1186/s12879-023-08862-0 |
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