Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry
A simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware. Peaks for active ingredients were observed in the spectra recorded from intact pharmaceutical tablets placed in this source. A flow of h...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-06-01
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| Series: | Journal of Pharmaceutical Analysis |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S209517791300107X |
| _version_ | 1818349671011057664 |
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| author | Athula B. Attygalle Freneil B. Jariwala Julius Pavlov Zhihua Yang Jason A. Mahr Mabel Oviedo |
| author_facet | Athula B. Attygalle Freneil B. Jariwala Julius Pavlov Zhihua Yang Jason A. Mahr Mabel Oviedo |
| author_sort | Athula B. Attygalle |
| collection | DOAJ |
| description | A simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware. Peaks for active ingredients were observed in the spectra recorded from intact pharmaceutical tablets placed in this source. A flow of heated nitrogen was used to thermally desorb analytes to gas phase. The desorption temperatures were sometimes as low as 50 °C. For example, negative-ion spectra recorded from an aspirin tablet showed peaks at m/z 137 (salicylate anion) and 179 (acetylsalicylate anion) which were absent in the background spectra. The overall ion intensity increased as the desorption gas temperature was elevated. Within the same acquisition experiment, both positive- and negative-ion signals for acetaminophen were recorded from volatiles emanating from Tylenol tablets by switching the polarity of the capillary back and forth. Moreover, different preparations of acetaminophen tablets could be distinguished by their ion-intensity thermograms. Keywords: Helium plasma ionization, Pharmaceutical tablets, HePI, DART, DESI |
| first_indexed | 2024-12-13T18:09:39Z |
| format | Article |
| id | doaj.art-477f315fcadd4ee8bb42baf1a2145145 |
| institution | Directory Open Access Journal |
| issn | 2095-1779 |
| language | English |
| last_indexed | 2024-12-13T18:09:39Z |
| publishDate | 2014-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj.art-477f315fcadd4ee8bb42baf1a21451452022-12-21T23:36:00ZengElsevierJournal of Pharmaceutical Analysis2095-17792014-06-0143166172Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometryAthula B. Attygalle0Freneil B. Jariwala1Julius Pavlov2Zhihua Yang3Jason A. Mahr4Mabel Oviedo5Center for Mass Spectrometry, Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA; Corresponding author. Tel.: +1 201 216 5575; fax: +1 201 216 8240.Center for Mass Spectrometry, Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USACenter for Mass Spectrometry, Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USACenter for Mass Spectrometry, Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USAMontville Township High School, 100 Horseneck Road, Montville, NJ 07045, USANorth Bergen High School, 7417 Kennedy Boulevard, North Bergen, NJ 07047, USAA simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware. Peaks for active ingredients were observed in the spectra recorded from intact pharmaceutical tablets placed in this source. A flow of heated nitrogen was used to thermally desorb analytes to gas phase. The desorption temperatures were sometimes as low as 50 °C. For example, negative-ion spectra recorded from an aspirin tablet showed peaks at m/z 137 (salicylate anion) and 179 (acetylsalicylate anion) which were absent in the background spectra. The overall ion intensity increased as the desorption gas temperature was elevated. Within the same acquisition experiment, both positive- and negative-ion signals for acetaminophen were recorded from volatiles emanating from Tylenol tablets by switching the polarity of the capillary back and forth. Moreover, different preparations of acetaminophen tablets could be distinguished by their ion-intensity thermograms. Keywords: Helium plasma ionization, Pharmaceutical tablets, HePI, DART, DESIhttp://www.sciencedirect.com/science/article/pii/S209517791300107X |
| spellingShingle | Athula B. Attygalle Freneil B. Jariwala Julius Pavlov Zhihua Yang Jason A. Mahr Mabel Oviedo Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry Journal of Pharmaceutical Analysis |
| title | Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry |
| title_full | Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry |
| title_fullStr | Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry |
| title_full_unstemmed | Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry |
| title_short | Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry |
| title_sort | direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization hepi mass spectrometry |
| url | http://www.sciencedirect.com/science/article/pii/S209517791300107X |
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