Neglected scrub typhus: An updated review with a focus on omics technologies
Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
| Subjects: | |
| Online Access: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2022;volume=15;issue=12;spage=531;epage=541;aulast=Sharma |
| _version_ | 1797955055242969088 |
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| author | Dixit Sharma Ankita Sharma Birbal Singh Sunil Kumar Shailender Kumar Verma |
| author_facet | Dixit Sharma Ankita Sharma Birbal Singh Sunil Kumar Shailender Kumar Verma |
| author_sort | Dixit Sharma |
| collection | DOAJ |
| description | Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children. The disease causes multiple organ failure and mortality rates may reach up to 70% due to a lack of appropriate healthcare. Currently available genome and proteome databases, and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen. This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen. The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted. |
| first_indexed | 2024-04-10T23:28:21Z |
| format | Article |
| id | doaj.art-4781e24815eb480fb58a132a79cc6541 |
| institution | Directory Open Access Journal |
| issn | 2352-4146 |
| language | English |
| last_indexed | 2024-04-10T23:28:21Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj.art-4781e24815eb480fb58a132a79cc65412023-01-12T11:09:19ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462022-01-01151253154110.4103/1995-7645.364003Neglected scrub typhus: An updated review with a focus on omics technologiesDixit SharmaAnkita SharmaBirbal SinghSunil KumarShailender Kumar VermaScrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children. The disease causes multiple organ failure and mortality rates may reach up to 70% due to a lack of appropriate healthcare. Currently available genome and proteome databases, and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen. This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen. The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted.http://www.apjtm.org/article.asp?issn=1995-7645;year=2022;volume=15;issue=12;spage=531;epage=541;aulast=Sharmaorientia tsutsugamushi; scrub typhus; therapeutic targets; omics technologies; drug discovery |
| spellingShingle | Dixit Sharma Ankita Sharma Birbal Singh Sunil Kumar Shailender Kumar Verma Neglected scrub typhus: An updated review with a focus on omics technologies Asian Pacific Journal of Tropical Medicine orientia tsutsugamushi; scrub typhus; therapeutic targets; omics technologies; drug discovery |
| title | Neglected scrub typhus: An updated review with a focus on omics technologies |
| title_full | Neglected scrub typhus: An updated review with a focus on omics technologies |
| title_fullStr | Neglected scrub typhus: An updated review with a focus on omics technologies |
| title_full_unstemmed | Neglected scrub typhus: An updated review with a focus on omics technologies |
| title_short | Neglected scrub typhus: An updated review with a focus on omics technologies |
| title_sort | neglected scrub typhus an updated review with a focus on omics technologies |
| topic | orientia tsutsugamushi; scrub typhus; therapeutic targets; omics technologies; drug discovery |
| url | http://www.apjtm.org/article.asp?issn=1995-7645;year=2022;volume=15;issue=12;spage=531;epage=541;aulast=Sharma |
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