Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy
Objective: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP). Methods: In this prospective observational case control study, HO-1 and s...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2018.1494187 |
| _version_ | 1811153894732988416 |
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| author | Muhammad Ilham Aldika Akbar Mita Herdiyantini Rozi Aditya Aryananda Nareswari CIninta Manggala Pasca Wardhana Khanisyah Erza Gumilar Budi Wicaksono Ernawati Agus Sulistyono Aditiawarman Hermanto Tri Joewono Nadir Abdullah Gustaaf Dekker Erry Gumilar Dachlan Muhammad Dikman Angsar |
| author_facet | Muhammad Ilham Aldika Akbar Mita Herdiyantini Rozi Aditya Aryananda Nareswari CIninta Manggala Pasca Wardhana Khanisyah Erza Gumilar Budi Wicaksono Ernawati Agus Sulistyono Aditiawarman Hermanto Tri Joewono Nadir Abdullah Gustaaf Dekker Erry Gumilar Dachlan Muhammad Dikman Angsar |
| author_sort | Muhammad Ilham Aldika Akbar |
| collection | DOAJ |
| description | Objective: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP). Methods: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24 h of hospital admission. Preeclampsia cases were divided into two groups based on gestational age at delivery: EO-PE (<34 weeks) and LO-PE (≥34 weeks). A total of 45 patients were involved in this study. Result: Maternal serum level of sFlt-1 was higher in EO-PE than LO-PE and NP groups (mean ± SD; 14.50 ± 17.12 ng/ml vs 5.20 ± 6.69 ng/ml vs 2.72 ± 1.2 ng/ml [p = 0.020]. Maternal serum level of HO-1 was not different between EO-PE, LO-PE, and NP groups (p = 0.681). Birthweights were significantly lower in the EO-PE group compared with the LO-PE and NP groups (1580 ± 536 g vs 2635 ± 578 g vs 3010 ± 371 g [p = 0.000]). The rate of small for gestational age infant (26.7% vs 6.7% vs 0%; p = 0.046) and perinatal death (20% vs 0 vs 0; p = 0.037) was also significantly higher in EO-PE compared to LO-PE and NP. The maternal sFlt-1 level was negatively correlated with birthweight (p = 0.006; CC = −0.445). Conclusion: This study did not find a correlation between maternal HO-1 levels and sFlt-1 levels. Maternal serum sFLt-1 levels in preeclampsia were higher in EO-PE and were associated with a worse perinatal outcome. |
| first_indexed | 2024-03-11T23:46:55Z |
| format | Article |
| id | doaj.art-47820a4d273a496da4dca21c6283215b |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:46:55Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-47820a4d273a496da4dca21c6283215b2023-09-19T09:24:42ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652018-10-0137417518110.1080/10641955.2018.14941871494187Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancyMuhammad Ilham Aldika Akbar0Mita Herdiyantini1Rozi Aditya Aryananda2Nareswari CIninta3Manggala Pasca Wardhana4Khanisyah Erza Gumilar5Budi Wicaksono6Ernawati7Agus Sulistyono8Aditiawarman9Hermanto Tri Joewono10Nadir Abdullah11Gustaaf Dekker12Erry Gumilar Dachlan13Muhammad Dikman Angsar14Universitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaObjective: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP). Methods: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24 h of hospital admission. Preeclampsia cases were divided into two groups based on gestational age at delivery: EO-PE (<34 weeks) and LO-PE (≥34 weeks). A total of 45 patients were involved in this study. Result: Maternal serum level of sFlt-1 was higher in EO-PE than LO-PE and NP groups (mean ± SD; 14.50 ± 17.12 ng/ml vs 5.20 ± 6.69 ng/ml vs 2.72 ± 1.2 ng/ml [p = 0.020]. Maternal serum level of HO-1 was not different between EO-PE, LO-PE, and NP groups (p = 0.681). Birthweights were significantly lower in the EO-PE group compared with the LO-PE and NP groups (1580 ± 536 g vs 2635 ± 578 g vs 3010 ± 371 g [p = 0.000]). The rate of small for gestational age infant (26.7% vs 6.7% vs 0%; p = 0.046) and perinatal death (20% vs 0 vs 0; p = 0.037) was also significantly higher in EO-PE compared to LO-PE and NP. The maternal sFlt-1 level was negatively correlated with birthweight (p = 0.006; CC = −0.445). Conclusion: This study did not find a correlation between maternal HO-1 levels and sFlt-1 levels. Maternal serum sFLt-1 levels in preeclampsia were higher in EO-PE and were associated with a worse perinatal outcome.http://dx.doi.org/10.1080/10641955.2018.1494187heme oxygenase 1 (ho-1)soluble fms like tyrosine kinase (sflt-1)early onset preeclampsialate onset preeclampsianeonatal outcomeiugr |
| spellingShingle | Muhammad Ilham Aldika Akbar Mita Herdiyantini Rozi Aditya Aryananda Nareswari CIninta Manggala Pasca Wardhana Khanisyah Erza Gumilar Budi Wicaksono Ernawati Agus Sulistyono Aditiawarman Hermanto Tri Joewono Nadir Abdullah Gustaaf Dekker Erry Gumilar Dachlan Muhammad Dikman Angsar Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy Hypertension in Pregnancy heme oxygenase 1 (ho-1) soluble fms like tyrosine kinase (sflt-1) early onset preeclampsia late onset preeclampsia neonatal outcome iugr |
| title | Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy |
| title_full | Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy |
| title_fullStr | Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy |
| title_full_unstemmed | Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy |
| title_short | Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy |
| title_sort | serum heme oxygenase 1 ho 1 soluble fms like tyrosine kinase sflt 1 level and neonatal outcome in early onset late onset preeclampsia and normal pregnancy |
| topic | heme oxygenase 1 (ho-1) soluble fms like tyrosine kinase (sflt-1) early onset preeclampsia late onset preeclampsia neonatal outcome iugr |
| url | http://dx.doi.org/10.1080/10641955.2018.1494187 |
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