Vancomycin-nanofunctionalized peptide-enriched silk fibroin to prevent methicillin-resistant Staphylococcus epidermidis-induced femoral nonunions in rats

Vancomycin-nanofunctionalized peptide-enriched silk fibroin to prevent methicillin-resistant Staphylococcus epidermidis-induced femoral nonunions in rats

IntroductionImplant-related infections and infected fractures are significant burdens in orthopedics. Staphylococcus epidermidis is one of the main causes of bone infections related to biofilm formation upon implants. Current antibiotic prophylaxis/therapy is often inadequate to prevent biofilm form...

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Bibliographic Details
Main Authors: Marta Bottagisio, Silvia Palombella, Silvia Lopa, Fabio Sangalli, Paolo Savadori, Marco Biagiotti, Zili Sideratou, Dimitris Tsiourvas, Arianna B. Lovati
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Staphylococcus epidermidis
implant-related bone infections
biofilm
nanoparticles
osteoconductive peptides
silk fibroin
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1056912/full

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