Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome
Abstract We report the first case of autoimmune pulmonary alveolar proteinosis (PAP) associated with and preceding myelodysplastic syndrome. A 74‐year‐old female with a history of polymyalgia rheumatica presented with six months history of progressive exertional breathlessness. Examination revealed...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-07-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.569 |
| _version_ | 1818203318455894016 |
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| author | Chuan Tai Foo Louis Chhor Francis Thien |
| author_facet | Chuan Tai Foo Louis Chhor Francis Thien |
| author_sort | Chuan Tai Foo |
| collection | DOAJ |
| description | Abstract We report the first case of autoimmune pulmonary alveolar proteinosis (PAP) associated with and preceding myelodysplastic syndrome. A 74‐year‐old female with a history of polymyalgia rheumatica presented with six months history of progressive exertional breathlessness. Examination revealed bilateral chest crackles and exertional desaturation. A diagnosis of autoimmune PAP was made based on the presence of autoantibodies to granulocyte‐macrophage colony‐stimulating factor and characteristic findings on chest computed tomography, bronchoalveolar lavage, and transbronchial biopsies. Bilateral whole lung lavage was performed with prompt improvement in symptoms. Fourteen months later, she presented with new breathlessness and was diagnosed with myelodysplasia on bone marrow biopsy. No recurrence of alveolar proteinosis was detected. This case highlights the importance of follow‐up and screening of patients with autoimmune PAP for haematological conditions. |
| first_indexed | 2024-12-12T03:23:26Z |
| format | Article |
| id | doaj.art-4784604b6abe43888a41309fc45eeaaf |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-12-12T03:23:26Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-4784604b6abe43888a41309fc45eeaaf2022-12-22T00:40:06ZengWileyRespirology Case Reports2051-33802020-07-0185n/an/a10.1002/rcr2.569Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndromeChuan Tai Foo0Louis Chhor1Francis Thien2Eastern Health Melbourne VIC AustraliaEastern Health Melbourne VIC AustraliaEastern Health Melbourne VIC AustraliaAbstract We report the first case of autoimmune pulmonary alveolar proteinosis (PAP) associated with and preceding myelodysplastic syndrome. A 74‐year‐old female with a history of polymyalgia rheumatica presented with six months history of progressive exertional breathlessness. Examination revealed bilateral chest crackles and exertional desaturation. A diagnosis of autoimmune PAP was made based on the presence of autoantibodies to granulocyte‐macrophage colony‐stimulating factor and characteristic findings on chest computed tomography, bronchoalveolar lavage, and transbronchial biopsies. Bilateral whole lung lavage was performed with prompt improvement in symptoms. Fourteen months later, she presented with new breathlessness and was diagnosed with myelodysplasia on bone marrow biopsy. No recurrence of alveolar proteinosis was detected. This case highlights the importance of follow‐up and screening of patients with autoimmune PAP for haematological conditions.https://doi.org/10.1002/rcr2.569Autoimmunemyelodysplastic syndromepulmonary alveolar proteinosis |
| spellingShingle | Chuan Tai Foo Louis Chhor Francis Thien Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome Respirology Case Reports Autoimmune myelodysplastic syndrome pulmonary alveolar proteinosis |
| title | Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome |
| title_full | Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome |
| title_fullStr | Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome |
| title_full_unstemmed | Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome |
| title_short | Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome |
| title_sort | autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome |
| topic | Autoimmune myelodysplastic syndrome pulmonary alveolar proteinosis |
| url | https://doi.org/10.1002/rcr2.569 |
| work_keys_str_mv | AT chuantaifoo autoimmunepulmonaryalveolarproteinosispriortomyelodysplasticsyndrome AT louischhor autoimmunepulmonaryalveolarproteinosispriortomyelodysplasticsyndrome AT francisthien autoimmunepulmonaryalveolarproteinosispriortomyelodysplasticsyndrome |