Exposure to N,N-diethyl-m-toluamide and cardiovascular diseases in adults
Although growing evidence suggests that N,N-diethyl-m-toluamide (DEET) has adverse effects on public health, the relationship of DEET with cardiovascular disease (CVD) is still largely unknown. The purpose of this study was, therefore, to evaluate the association between DEET exposure and total and...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.922005/full |
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| author | Shiwei Yan Jianing Wang Jiaxu Xu Wenbo Jiang Menglin Xiong Ziteng Cao Yu Wang Ziqi Wang Tongfang Zhang Zheng Wang Changhao Sun Shaoying Hou Wei Wei |
| author_facet | Shiwei Yan Jianing Wang Jiaxu Xu Wenbo Jiang Menglin Xiong Ziteng Cao Yu Wang Ziqi Wang Tongfang Zhang Zheng Wang Changhao Sun Shaoying Hou Wei Wei |
| author_sort | Shiwei Yan |
| collection | DOAJ |
| description | Although growing evidence suggests that N,N-diethyl-m-toluamide (DEET) has adverse effects on public health, the relationship of DEET with cardiovascular disease (CVD) is still largely unknown. The purpose of this study was, therefore, to evaluate the association between DEET exposure and total and specific CVD among the US adults. In this cross-sectional study, a total of 5,972 participants were selected from the National Health and Nutrition Examination Survey (NHANES) 2007–2014. CVD was defined as a combination of congestive heart failure (CHF), coronary heart disease (CHD), angina, heart attack, or stroke. Logistic regression models were used to evaluate the association between DEET metabolites and the risks of total and specific CVD. Compared to the lowest quartile, 3-(diethylcarbamoyl) benzoic acid (DCBA) in the highest quartile was associated with the increased risks of CVD (odds ratio [OR]: 1.32, 95% CI: 1.03–1.68, P for trend = 0.025) and CHD (OR: 1.57, 95% CI: 1.10–2.25, P for trend = 0.017), after adjustment for potential covariates. Nevertheless, exposure to DCBA was not significantly associated with heart attack, CHF, angina, and stroke. Further studies are required to confirm these findings and identify the underlying mechanisms. |
| first_indexed | 2024-04-11T09:22:24Z |
| format | Article |
| id | doaj.art-47854cafd33040c99d36690006186723 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T09:22:24Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-47854cafd33040c99d366900061867232022-12-22T04:32:07ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.922005922005Exposure to N,N-diethyl-m-toluamide and cardiovascular diseases in adultsShiwei Yan0Jianing Wang1Jiaxu Xu2Wenbo Jiang3Menglin Xiong4Ziteng Cao5Yu Wang6Ziqi Wang7Tongfang Zhang8Zheng Wang9Changhao Sun10Shaoying Hou11Wei Wei12Department of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Cerebrovascular Disease, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, ChinaAlthough growing evidence suggests that N,N-diethyl-m-toluamide (DEET) has adverse effects on public health, the relationship of DEET with cardiovascular disease (CVD) is still largely unknown. The purpose of this study was, therefore, to evaluate the association between DEET exposure and total and specific CVD among the US adults. In this cross-sectional study, a total of 5,972 participants were selected from the National Health and Nutrition Examination Survey (NHANES) 2007–2014. CVD was defined as a combination of congestive heart failure (CHF), coronary heart disease (CHD), angina, heart attack, or stroke. Logistic regression models were used to evaluate the association between DEET metabolites and the risks of total and specific CVD. Compared to the lowest quartile, 3-(diethylcarbamoyl) benzoic acid (DCBA) in the highest quartile was associated with the increased risks of CVD (odds ratio [OR]: 1.32, 95% CI: 1.03–1.68, P for trend = 0.025) and CHD (OR: 1.57, 95% CI: 1.10–2.25, P for trend = 0.017), after adjustment for potential covariates. Nevertheless, exposure to DCBA was not significantly associated with heart attack, CHF, angina, and stroke. Further studies are required to confirm these findings and identify the underlying mechanisms.https://www.frontiersin.org/articles/10.3389/fpubh.2022.922005/fullDEETCVDCHDDCBANHANES |
| spellingShingle | Shiwei Yan Jianing Wang Jiaxu Xu Wenbo Jiang Menglin Xiong Ziteng Cao Yu Wang Ziqi Wang Tongfang Zhang Zheng Wang Changhao Sun Shaoying Hou Wei Wei Exposure to N,N-diethyl-m-toluamide and cardiovascular diseases in adults Frontiers in Public Health DEET CVD CHD DCBA NHANES |
| title | Exposure to N,N-diethyl-m-toluamide and cardiovascular diseases in adults |
| title_full | Exposure to N,N-diethyl-m-toluamide and cardiovascular diseases in adults |
| title_fullStr | Exposure to N,N-diethyl-m-toluamide and cardiovascular diseases in adults |
| title_full_unstemmed | Exposure to N,N-diethyl-m-toluamide and cardiovascular diseases in adults |
| title_short | Exposure to N,N-diethyl-m-toluamide and cardiovascular diseases in adults |
| title_sort | exposure to n n diethyl m toluamide and cardiovascular diseases in adults |
| topic | DEET CVD CHD DCBA NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.922005/full |
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