Potential roles and prognostic significance of exosomes in cancer drug resistance
Abstract Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 nm released by eukaryotic cells that contain genetic materials, proteins, and lipid...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-020-00515-y |
| _version_ | 1819056640993787904 |
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| author | Mostafa Mostafazadeh Nasser Samadi Houman Kahroba Behzad Baradaran Sanya Haiaty Mohammad Nouri |
| author_facet | Mostafa Mostafazadeh Nasser Samadi Houman Kahroba Behzad Baradaran Sanya Haiaty Mohammad Nouri |
| author_sort | Mostafa Mostafazadeh |
| collection | DOAJ |
| description | Abstract Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 nm released by eukaryotic cells that contain genetic materials, proteins, and lipids which mediate a specific cell-to-cell communication. The potential roles of exosomes in intrinsic and acquired drug resistance have been reported in several studies. Furthermore, a line of evidence suggested that the content of exosomes released from tumor cells in biological samples may be associated with the clinical outcomes of cancer patients. In this review, we highlighted the recent studies regarding the potential roles of exosomes in tumor initiation, progression, and chemoresistance. This study suggests the possible role of exosomes for drug delivery and their contents in prognosis and resistance to chemotherapy in cancer patients. |
| first_indexed | 2024-12-21T13:26:38Z |
| format | Article |
| id | doaj.art-4788196127b94a9e8f34aec7d1a83d82 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-12-21T13:26:38Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-4788196127b94a9e8f34aec7d1a83d822022-12-21T19:02:25ZengBMCCell & Bioscience2045-37012021-01-0111111510.1186/s13578-020-00515-yPotential roles and prognostic significance of exosomes in cancer drug resistanceMostafa Mostafazadeh0Nasser Samadi1Houman Kahroba2Behzad Baradaran3Sanya Haiaty4Mohammad Nouri5Drug Applied Research Center, Tabriz University of Medical SciencesDrug Applied Research Center, Tabriz University of Medical SciencesDepartment of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesImmunology Research Center, Faculty of Medicine, Tabriz University of Medical SciencesDepartment of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical SciencesDrug Applied Research Center, Tabriz University of Medical SciencesAbstract Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 nm released by eukaryotic cells that contain genetic materials, proteins, and lipids which mediate a specific cell-to-cell communication. The potential roles of exosomes in intrinsic and acquired drug resistance have been reported in several studies. Furthermore, a line of evidence suggested that the content of exosomes released from tumor cells in biological samples may be associated with the clinical outcomes of cancer patients. In this review, we highlighted the recent studies regarding the potential roles of exosomes in tumor initiation, progression, and chemoresistance. This study suggests the possible role of exosomes for drug delivery and their contents in prognosis and resistance to chemotherapy in cancer patients.https://doi.org/10.1186/s13578-020-00515-yBiomarkerChemoresistanceExtracellular vesiclesMicroRNAsTumor microenvironment |
| spellingShingle | Mostafa Mostafazadeh Nasser Samadi Houman Kahroba Behzad Baradaran Sanya Haiaty Mohammad Nouri Potential roles and prognostic significance of exosomes in cancer drug resistance Cell & Bioscience Biomarker Chemoresistance Extracellular vesicles MicroRNAs Tumor microenvironment |
| title | Potential roles and prognostic significance of exosomes in cancer drug resistance |
| title_full | Potential roles and prognostic significance of exosomes in cancer drug resistance |
| title_fullStr | Potential roles and prognostic significance of exosomes in cancer drug resistance |
| title_full_unstemmed | Potential roles and prognostic significance of exosomes in cancer drug resistance |
| title_short | Potential roles and prognostic significance of exosomes in cancer drug resistance |
| title_sort | potential roles and prognostic significance of exosomes in cancer drug resistance |
| topic | Biomarker Chemoresistance Extracellular vesicles MicroRNAs Tumor microenvironment |
| url | https://doi.org/10.1186/s13578-020-00515-y |
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