Hacker Within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy
Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. It is the etiologic agent of human monocytotropic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis. Mechanisms by which E. chaffeensis establis...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00058/full |
| _version_ | 1818876827340374016 |
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| author | Taslima Taher Lina Tierra eFarris Tian eLuo Shubhajit eMitra Bing eZhu Jere W McBride |
| author_facet | Taslima Taher Lina Tierra eFarris Tian eLuo Shubhajit eMitra Bing eZhu Jere W McBride |
| author_sort | Taslima Taher Lina |
| collection | DOAJ |
| description | Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. It is the etiologic agent of human monocytotropic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis. Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. In this review, we discuss the recent advances in our understanding of the molecular and cellular mechanisms that underlie Ehrlichia host cellular reprogramming strategies that enable intracellular survival. |
| first_indexed | 2024-12-19T13:48:34Z |
| format | Article |
| id | doaj.art-4788337db22a413593ed47bb9b115933 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-19T13:48:34Z |
| publishDate | 2016-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-4788337db22a413593ed47bb9b1159332022-12-21T20:18:49ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882016-05-01610.3389/fcimb.2016.00058196864Hacker Within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming StrategyTaslima Taher Lina0Tierra eFarris1Tian eLuo2Shubhajit eMitra3Bing eZhu4Jere W McBride5University of Texas Medical BranchUniversity of Texas Medical BranchUniversity of Texas Medical BranchUniversity of Texas Medical BranchUniversity of Texas Medical BranchUniversity of Texas Medical BranchEhrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. It is the etiologic agent of human monocytotropic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis. Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. In this review, we discuss the recent advances in our understanding of the molecular and cellular mechanisms that underlie Ehrlichia host cellular reprogramming strategies that enable intracellular survival.http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00058/fullEhrlichia chaffeensisCell signalingepigenetics.innate immune responsesecretion systemPost translational modification (PTM) |
| spellingShingle | Taslima Taher Lina Tierra eFarris Tian eLuo Shubhajit eMitra Bing eZhu Jere W McBride Hacker Within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy Frontiers in Cellular and Infection Microbiology Ehrlichia chaffeensis Cell signaling epigenetics. innate immune response secretion system Post translational modification (PTM) |
| title | Hacker Within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy |
| title_full | Hacker Within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy |
| title_fullStr | Hacker Within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy |
| title_full_unstemmed | Hacker Within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy |
| title_short | Hacker Within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy |
| title_sort | hacker within ehrlichia chaffeensis effector driven phagocyte reprogramming strategy |
| topic | Ehrlichia chaffeensis Cell signaling epigenetics. innate immune response secretion system Post translational modification (PTM) |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00058/full |
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