Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer
ObjectiveThe purpose of this study was to determine the prognostic implications of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and its dynamic change during chemotherapy in patients with advanced epithelial ovarian cancer undergoing neoadjuvant chemotherapy.MethodsWe performed a retrospect...
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| Format: | Article |
| Language: | English |
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Korean Society of Obstetrics and Gynecology
2018-03-01
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| Series: | Obstetrics & Gynecology Science |
| Subjects: | |
| Online Access: | http://ogscience.org/upload/pdf/ogs-61-227.pdf |
| _version_ | 1819099285187198976 |
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| author | Yun-Ji Kim Inha Lee Young Shin Chung EunJi Nam Sunghoon Kim Sang-Wun Kim Young Tae Kim Jung-Yun Lee |
| author_facet | Yun-Ji Kim Inha Lee Young Shin Chung EunJi Nam Sunghoon Kim Sang-Wun Kim Young Tae Kim Jung-Yun Lee |
| author_sort | Yun-Ji Kim |
| collection | DOAJ |
| description | ObjectiveThe purpose of this study was to determine the prognostic implications of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and its dynamic change during chemotherapy in patients with advanced epithelial ovarian cancer undergoing neoadjuvant chemotherapy.MethodsWe performed a retrospective analysis of 203 patients who underwent neoadjuvant chemotherapy prior to interval debulking surgery for advanced-stage ovarian cancer at Yonsei Cancer Hospital between 2007 and 2015. Pretreatment NLR was evaluated before starting neoadjuvant chemotherapy. Change in NLR was defined as the post-neoadjuvant NLR value divided by the initial value. The correlation of NLR and its dynamic change with chemotherapy response score, response rate, and recurrence was analyzed.ResultsThe NLR ranged from 0.64 to 22.8. In univariate analyses, a higher pretreatment NLR (>3.81) was associated with poor overall survival (OS), but not progression-free survival (PFS). Through multivariate analysis, high pretreatment NLR was shown to be an independent parameter affecting OS, but not necessarily PFS. Changes in NLR during chemotherapy were better predictors of PFS than baseline NLR. Patients with increased NLR during chemotherapy showed significantly poor PFS, and this change was an independent predictor of PFS.ConclusionPretreatment NLR and its dynamic change during chemotherapy may be important prognostic factors in patients who undergo neoadjuvant chemotherapy. |
| first_indexed | 2024-12-22T00:44:27Z |
| format | Article |
| id | doaj.art-4788572cb5b14aafbb6520b2f330d22e |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-12-22T00:44:27Z |
| publishDate | 2018-03-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-4788572cb5b14aafbb6520b2f330d22e2022-12-21T18:44:35ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802018-03-0161222723410.5468/ogs.2018.61.2.227471Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancerYun-Ji Kim0Inha Lee1Young Shin Chung2EunJi Nam3Sunghoon Kim4Sang-Wun Kim5Young Tae Kim6Jung-Yun Lee7Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, , , .KoreaDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, , , .KoreaDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, , , .KoreaDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, , , .KoreaDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, , , .KoreaDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, , , .KoreaDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, , , .KoreaDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, , , .KoreaObjectiveThe purpose of this study was to determine the prognostic implications of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and its dynamic change during chemotherapy in patients with advanced epithelial ovarian cancer undergoing neoadjuvant chemotherapy.MethodsWe performed a retrospective analysis of 203 patients who underwent neoadjuvant chemotherapy prior to interval debulking surgery for advanced-stage ovarian cancer at Yonsei Cancer Hospital between 2007 and 2015. Pretreatment NLR was evaluated before starting neoadjuvant chemotherapy. Change in NLR was defined as the post-neoadjuvant NLR value divided by the initial value. The correlation of NLR and its dynamic change with chemotherapy response score, response rate, and recurrence was analyzed.ResultsThe NLR ranged from 0.64 to 22.8. In univariate analyses, a higher pretreatment NLR (>3.81) was associated with poor overall survival (OS), but not progression-free survival (PFS). Through multivariate analysis, high pretreatment NLR was shown to be an independent parameter affecting OS, but not necessarily PFS. Changes in NLR during chemotherapy were better predictors of PFS than baseline NLR. Patients with increased NLR during chemotherapy showed significantly poor PFS, and this change was an independent predictor of PFS.ConclusionPretreatment NLR and its dynamic change during chemotherapy may be important prognostic factors in patients who undergo neoadjuvant chemotherapy.http://ogscience.org/upload/pdf/ogs-61-227.pdfbiomarkersneutrophilsovarian neoplasmsprognosistreatment outcomes |
| spellingShingle | Yun-Ji Kim Inha Lee Young Shin Chung EunJi Nam Sunghoon Kim Sang-Wun Kim Young Tae Kim Jung-Yun Lee Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer Obstetrics & Gynecology Science biomarkers neutrophils ovarian neoplasms prognosis treatment outcomes |
| title | Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer |
| title_full | Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer |
| title_fullStr | Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer |
| title_full_unstemmed | Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer |
| title_short | Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer |
| title_sort | pretreatment neutrophil to lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer |
| topic | biomarkers neutrophils ovarian neoplasms prognosis treatment outcomes |
| url | http://ogscience.org/upload/pdf/ogs-61-227.pdf |
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