Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process
Abstract Senescent microglia are a distinct microglial phenotype present in aging brain that have been implicated in the progression of aging and age-related neurodegenerative diseases. However, the specific mechanisms that trigger microglial senescence are largely unknown. Quinolinic acid (QA) is a...
Main Authors: | Anjila Dongol, Xi Chen, Peng Zheng, Zehra Boz Seyhan, Xu-Feng Huang |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-12-01
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Series: | Biology Direct |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13062-023-00445-y |
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