Research progress of plant-derived natural products in thyroid carcinoma
Thyroid carcinoma (TC) is a prevalent malignancy of the endocrine system, with a notable rise in its detection rate in recent decades. The primary therapeutic approaches for TC now encompass thyroidectomy and radioactive iodine therapy, yielding favorable prognoses for the majority of patients. TC s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1279384/full |
| _version_ | 1797359890028560384 |
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| author | Qiujing Du Qiujing Du Weidong Shen |
| author_facet | Qiujing Du Qiujing Du Weidong Shen |
| author_sort | Qiujing Du |
| collection | DOAJ |
| description | Thyroid carcinoma (TC) is a prevalent malignancy of the endocrine system, with a notable rise in its detection rate in recent decades. The primary therapeutic approaches for TC now encompass thyroidectomy and radioactive iodine therapy, yielding favorable prognoses for the majority of patients. TC survivors may necessitate ongoing surveillance, remedial treatment, and thyroid hormone supplementation, while also enduring the adverse consequences of thyroid hormone fluctuations, surgical complications, or side effects linked to radioactive iodine administration, and encountering enduring physical, psychosocial, and economic hardships. In vitro and in vivo studies of natural products against TC are demonstrating the potential of these natural products as alternatives to the treatment of thyroid cancer. This therapy may offer greater convenience, affordability, and acceptability than traditional therapies. In the early screening of natural products, we mainly use a combination of database prediction and literature search. The pharmacological effects on TC of selected natural products (quercetin, genistein, apigenin, luteolin, chrysin, myricetin, resveratrol, curcumin and nobiletin), which hold promise for therapeutic applications in TC, are reviewed in detail in this article through most of the cell-level evidence, animal-level evidence, and a small amount of human-level evidence. In addition, this article explores possible issues, such as bioavailability, drug safety. |
| first_indexed | 2024-03-08T15:30:19Z |
| format | Article |
| id | doaj.art-4789c154ec664771982e535d9adee4ed |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-03-08T15:30:19Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-4789c154ec664771982e535d9adee4ed2024-01-10T04:47:05ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462024-01-011110.3389/fchem.2023.12793841279384Research progress of plant-derived natural products in thyroid carcinomaQiujing Du0Qiujing Du1Weidong Shen2The Affiliated Jiangyin People’s Hospital of Nantong University, Jiangyin, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThe Affiliated Jiangyin People’s Hospital of Nantong University, Jiangyin, ChinaThyroid carcinoma (TC) is a prevalent malignancy of the endocrine system, with a notable rise in its detection rate in recent decades. The primary therapeutic approaches for TC now encompass thyroidectomy and radioactive iodine therapy, yielding favorable prognoses for the majority of patients. TC survivors may necessitate ongoing surveillance, remedial treatment, and thyroid hormone supplementation, while also enduring the adverse consequences of thyroid hormone fluctuations, surgical complications, or side effects linked to radioactive iodine administration, and encountering enduring physical, psychosocial, and economic hardships. In vitro and in vivo studies of natural products against TC are demonstrating the potential of these natural products as alternatives to the treatment of thyroid cancer. This therapy may offer greater convenience, affordability, and acceptability than traditional therapies. In the early screening of natural products, we mainly use a combination of database prediction and literature search. The pharmacological effects on TC of selected natural products (quercetin, genistein, apigenin, luteolin, chrysin, myricetin, resveratrol, curcumin and nobiletin), which hold promise for therapeutic applications in TC, are reviewed in detail in this article through most of the cell-level evidence, animal-level evidence, and a small amount of human-level evidence. In addition, this article explores possible issues, such as bioavailability, drug safety.https://www.frontiersin.org/articles/10.3389/fchem.2023.1279384/fullnatural productthyroid carcinomatreatment challengesthyroid carcinoma survivorsredifferentiationdrug resistance |
| spellingShingle | Qiujing Du Qiujing Du Weidong Shen Research progress of plant-derived natural products in thyroid carcinoma Frontiers in Chemistry natural product thyroid carcinoma treatment challenges thyroid carcinoma survivors redifferentiation drug resistance |
| title | Research progress of plant-derived natural products in thyroid carcinoma |
| title_full | Research progress of plant-derived natural products in thyroid carcinoma |
| title_fullStr | Research progress of plant-derived natural products in thyroid carcinoma |
| title_full_unstemmed | Research progress of plant-derived natural products in thyroid carcinoma |
| title_short | Research progress of plant-derived natural products in thyroid carcinoma |
| title_sort | research progress of plant derived natural products in thyroid carcinoma |
| topic | natural product thyroid carcinoma treatment challenges thyroid carcinoma survivors redifferentiation drug resistance |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2023.1279384/full |
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