Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics
Summary: The role of immune cells in the pathogenesis of ischemic heart failure (IHF) is well-established. However, identifying key genes in patients with IHF remains a challenge. We obtained two IHF datasets from the GEO database (GSE76701 and GSE21610), and identified four potential diagnostic can...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223021983 |
| _version_ | 1797658962852577280 |
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| author | Yiding Yu Xiujuan Liu Yitao Xue Yan Li |
| author_facet | Yiding Yu Xiujuan Liu Yitao Xue Yan Li |
| author_sort | Yiding Yu |
| collection | DOAJ |
| description | Summary: The role of immune cells in the pathogenesis of ischemic heart failure (IHF) is well-established. However, identifying key genes in patients with IHF remains a challenge. We obtained two IHF datasets from the GEO database (GSE76701 and GSE21610), and identified four potential diagnostic candidate genes for IHF by using bioinformatics and machine learning algorithms, namely RNASE2, MFAP4, CHRDL1, and KCNN3. We constructed nomogram and validated the diagnostic value of these genes on additional GEO datasets (GSE57338). The results showed that these four genes had high diagnostic value (area under the curve value of 0.961). Furthermore, our immune infiltration analysis revealed the presence of three dysregulated immune cells in IHF, namely macrophages M2, monocytes, and T cells gamma delta. We also explored the potential molecular mechanisms of IHF. These findings provide new insights into the pathogenesis, diagnosis, and treatment of IHF. |
| first_indexed | 2024-03-11T18:07:01Z |
| format | Article |
| id | doaj.art-478a1f86f24e47be8ba877782cad283c |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-11T18:07:01Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-478a1f86f24e47be8ba877782cad283c2023-10-17T04:07:19ZengElsevieriScience2589-00422023-11-012611108121Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformaticsYiding Yu0Xiujuan Liu1Yitao Xue2Yan Li3Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China; Corresponding authorAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China; Corresponding authorSummary: The role of immune cells in the pathogenesis of ischemic heart failure (IHF) is well-established. However, identifying key genes in patients with IHF remains a challenge. We obtained two IHF datasets from the GEO database (GSE76701 and GSE21610), and identified four potential diagnostic candidate genes for IHF by using bioinformatics and machine learning algorithms, namely RNASE2, MFAP4, CHRDL1, and KCNN3. We constructed nomogram and validated the diagnostic value of these genes on additional GEO datasets (GSE57338). The results showed that these four genes had high diagnostic value (area under the curve value of 0.961). Furthermore, our immune infiltration analysis revealed the presence of three dysregulated immune cells in IHF, namely macrophages M2, monocytes, and T cells gamma delta. We also explored the potential molecular mechanisms of IHF. These findings provide new insights into the pathogenesis, diagnosis, and treatment of IHF.http://www.sciencedirect.com/science/article/pii/S2589004223021983BioinformaticsCardiovascular medicineGenes |
| spellingShingle | Yiding Yu Xiujuan Liu Yitao Xue Yan Li Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics iScience Bioinformatics Cardiovascular medicine Genes |
| title | Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics |
| title_full | Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics |
| title_fullStr | Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics |
| title_full_unstemmed | Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics |
| title_short | Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics |
| title_sort | identification of immune related genes for the diagnosis of ischemic heart failure based on bioinformatics |
| topic | Bioinformatics Cardiovascular medicine Genes |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223021983 |
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