Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus.
The global incidence of arboviral diseases transmitted by Aedes mosquitoes, including dengue, chikungunya, yellow fever, and Zika, has increased dramatically in recent decades. The release of Aedes aegypti carrying the maternally inherited symbiont Wolbachia as an intervention to control arboviruses...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-03-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0007926 |
| _version_ | 1831569361599463424 |
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| author | Maria Vittoria Mancini Christie S Herd Thomas H Ant Shivan M Murdochy Steven P Sinkins |
| author_facet | Maria Vittoria Mancini Christie S Herd Thomas H Ant Shivan M Murdochy Steven P Sinkins |
| author_sort | Maria Vittoria Mancini |
| collection | DOAJ |
| description | The global incidence of arboviral diseases transmitted by Aedes mosquitoes, including dengue, chikungunya, yellow fever, and Zika, has increased dramatically in recent decades. The release of Aedes aegypti carrying the maternally inherited symbiont Wolbachia as an intervention to control arboviruses is being trialled in several countries. However, these efforts are compromised in many endemic regions due to the co-localization of the secondary vector Aedes albopictus, the Asian tiger mosquito. Ae. albopictus has an expanding global distribution following incursions into a number of new territories. To date, only the wMel and wPip strains of Wolbachia have been reported to be transferred into and characterized in this vector. A Wolbachia strain naturally infecting Drosophila simulans, wAu, was selected for transfer into a Malaysian Ae. albopictus line to create a novel triple-strain infection. The newly generated line showed self-compatibility, moderate fitness cost and complete resistance to Zika and dengue infections. |
| first_indexed | 2024-12-17T12:32:10Z |
| format | Article |
| id | doaj.art-478c942e09ec43b59c2a5bae56599834 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-17T12:32:10Z |
| publishDate | 2020-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-478c942e09ec43b59c2a5bae565998342022-12-21T21:48:30ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352020-03-01143e000792610.1371/journal.pntd.0007926Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus.Maria Vittoria ManciniChristie S HerdThomas H AntShivan M MurdochySteven P SinkinsThe global incidence of arboviral diseases transmitted by Aedes mosquitoes, including dengue, chikungunya, yellow fever, and Zika, has increased dramatically in recent decades. The release of Aedes aegypti carrying the maternally inherited symbiont Wolbachia as an intervention to control arboviruses is being trialled in several countries. However, these efforts are compromised in many endemic regions due to the co-localization of the secondary vector Aedes albopictus, the Asian tiger mosquito. Ae. albopictus has an expanding global distribution following incursions into a number of new territories. To date, only the wMel and wPip strains of Wolbachia have been reported to be transferred into and characterized in this vector. A Wolbachia strain naturally infecting Drosophila simulans, wAu, was selected for transfer into a Malaysian Ae. albopictus line to create a novel triple-strain infection. The newly generated line showed self-compatibility, moderate fitness cost and complete resistance to Zika and dengue infections.https://doi.org/10.1371/journal.pntd.0007926 |
| spellingShingle | Maria Vittoria Mancini Christie S Herd Thomas H Ant Shivan M Murdochy Steven P Sinkins Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus. PLoS Neglected Tropical Diseases |
| title | Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus. |
| title_full | Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus. |
| title_fullStr | Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus. |
| title_full_unstemmed | Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus. |
| title_short | Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus. |
| title_sort | wolbachia strain wau efficiently blocks arbovirus transmission in aedes albopictus |
| url | https://doi.org/10.1371/journal.pntd.0007926 |
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