Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice
More and more discoveries have been made about the chronic toxic effects of aluminum, but the specific mechanism of action remains unclear. In this study, we explored the perturbation of aluminum on intestinal microflora and its effects on host and microbial metabolites through a more realistic nutr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322010545 |
| _version_ | 1798017912433278976 |
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| author | Rong Feng Yixuan Fan Liang Chen Qi Ge Jia Xu Ming Yang Keping Chen |
| author_facet | Rong Feng Yixuan Fan Liang Chen Qi Ge Jia Xu Ming Yang Keping Chen |
| author_sort | Rong Feng |
| collection | DOAJ |
| description | More and more discoveries have been made about the chronic toxic effects of aluminum, but the specific mechanism of action remains unclear. In this study, we explored the perturbation of aluminum on intestinal microflora and its effects on host and microbial metabolites through a more realistic nutrient absorption model. The microorganisms Turicibacter, Lactobacillus murinus, Lactobacillus_reuteri and Bifidobacterium pseudolongum may be the main targets of the aluminum affecting microbiota. Lysine, proline, putrescine, serotonin and cholesterol may be important metabolites affected by aluminum ions after the interference of intestinal flora composition, leading to abnormal metabolism pathways of amino acids and lipids in the body, and thus promoting inflammation and lesion. The possible mechanisms of aluminum action on the body: (1) Affecting immune cell response, ROS generation and production of a series of pro-inflammatory factors to promote inflammation; (2) Through the disturbance of intestinal microbiota composition structure, change the abundance of metabolites, and then affect amino acid metabolism, lipid metabolism pathways. The joint analysis of multiple omics showed significant difference in microbiome abundance and metabolomics expression between high dose group and the control group. |
| first_indexed | 2024-04-11T16:15:18Z |
| format | Article |
| id | doaj.art-478ea23cc4bf4d3a8fc5d53f99c59709 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-11T16:15:18Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-478ea23cc4bf4d3a8fc5d53f99c597092022-12-22T04:14:34ZengElsevierEcotoxicology and Environmental Safety0147-65132022-12-01247114214Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in miceRong Feng0Yixuan Fan1Liang Chen2Qi Ge3Jia Xu4Ming Yang5Keping Chen6School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu Province, ChinaSchool of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, ChinaSchool of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, ChinaSchool of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, ChinaSchool of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, ChinaSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu Province, ChinaSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu Province, China; School of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, China; Correspondence to: School of Life Sciences, Jiangsu University, Xuefu Road 301, Zhenjiang, China.More and more discoveries have been made about the chronic toxic effects of aluminum, but the specific mechanism of action remains unclear. In this study, we explored the perturbation of aluminum on intestinal microflora and its effects on host and microbial metabolites through a more realistic nutrient absorption model. The microorganisms Turicibacter, Lactobacillus murinus, Lactobacillus_reuteri and Bifidobacterium pseudolongum may be the main targets of the aluminum affecting microbiota. Lysine, proline, putrescine, serotonin and cholesterol may be important metabolites affected by aluminum ions after the interference of intestinal flora composition, leading to abnormal metabolism pathways of amino acids and lipids in the body, and thus promoting inflammation and lesion. The possible mechanisms of aluminum action on the body: (1) Affecting immune cell response, ROS generation and production of a series of pro-inflammatory factors to promote inflammation; (2) Through the disturbance of intestinal microbiota composition structure, change the abundance of metabolites, and then affect amino acid metabolism, lipid metabolism pathways. The joint analysis of multiple omics showed significant difference in microbiome abundance and metabolomics expression between high dose group and the control group.http://www.sciencedirect.com/science/article/pii/S014765132201054516 S rRNA sequencingMetabonomicsAluminum potassium sulfateFood additiveLipid metabolism |
| spellingShingle | Rong Feng Yixuan Fan Liang Chen Qi Ge Jia Xu Ming Yang Keping Chen Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice Ecotoxicology and Environmental Safety 16 S rRNA sequencing Metabonomics Aluminum potassium sulfate Food additive Lipid metabolism |
| title | Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice |
| title_full | Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice |
| title_fullStr | Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice |
| title_full_unstemmed | Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice |
| title_short | Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice |
| title_sort | based on 16 s rrna sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice |
| topic | 16 S rRNA sequencing Metabonomics Aluminum potassium sulfate Food additive Lipid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322010545 |
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