Pontine Infarct as Initial Presentation of Catastrophic Antiphospholipid Syndrome in Systemic Lupus Erythematous
Antiphospholipid syndrome (APLS) is an autoimmune condition which commonly manifests as an arterial or venous thrombosis affecting medium to large vessels, with the presence of antiphospholipid antibodies. APLS can be a primary disease by itself, or secondary to other autoimmune diseases, such as Sy...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Interna Publishing
2022-04-01
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| Series: | Acta Medica Indonesiana |
| Subjects: | |
| Online Access: | https://actamedindones.org/index.php/ijim/article/view/1427 |
| _version_ | 1818108222999887872 |
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| author | Rathika Rajah Rizna A Cader |
| author_facet | Rathika Rajah Rizna A Cader |
| author_sort | Rathika Rajah |
| collection | DOAJ |
| description | Antiphospholipid syndrome (APLS) is an autoimmune condition which commonly manifests as an arterial or venous thrombosis affecting medium to large vessels, with the presence of antiphospholipid antibodies. APLS can be a primary disease by itself, or secondary to other autoimmune diseases, such as Systemic Lupus Erythematosus (SLE). Catastrophic APLS is a rare but a fatal sequelae of APLS, affecting up to three or more organs, and progresses rapidly with a high mortality rate. We report a case of catastrophic APLS in a young woman with underlying SLE who presented to us with multiple cranial nerve palsies due to bilateral pontine infarct, and eventually developed deep vein thrombosis and pulmonary embolism during the course of the illness. She was treated with high dose corticosteroids and intravenous cyclophosphamide with biochemical improvement. In this case report, we would like to highlight the fact that our patient had bilateral pontine infarcts as the initial presentation, with no inciting events and antiphospholipid antibodies were negative during the acute illness. |
| first_indexed | 2024-12-11T02:11:56Z |
| format | Article |
| id | doaj.art-478ed2db0d594c49950cded7da950431 |
| institution | Directory Open Access Journal |
| issn | 0125-9326 2338-2732 |
| language | English |
| last_indexed | 2024-12-11T02:11:56Z |
| publishDate | 2022-04-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj.art-478ed2db0d594c49950cded7da9504312022-12-22T01:24:16ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322022-04-01542513Pontine Infarct as Initial Presentation of Catastrophic Antiphospholipid Syndrome in Systemic Lupus ErythematousRathika Rajah0Rizna A Cader1Department of Medicine, Universiti Kebangsaan Malaysia (UKM) Medical Centre, Cheras, Kuala Lumpur, MalaysiaNephrology Unit, Department of Medicine, UKM Medical Centre, Kuala Lumpur, MalaysiaAntiphospholipid syndrome (APLS) is an autoimmune condition which commonly manifests as an arterial or venous thrombosis affecting medium to large vessels, with the presence of antiphospholipid antibodies. APLS can be a primary disease by itself, or secondary to other autoimmune diseases, such as Systemic Lupus Erythematosus (SLE). Catastrophic APLS is a rare but a fatal sequelae of APLS, affecting up to three or more organs, and progresses rapidly with a high mortality rate. We report a case of catastrophic APLS in a young woman with underlying SLE who presented to us with multiple cranial nerve palsies due to bilateral pontine infarct, and eventually developed deep vein thrombosis and pulmonary embolism during the course of the illness. She was treated with high dose corticosteroids and intravenous cyclophosphamide with biochemical improvement. In this case report, we would like to highlight the fact that our patient had bilateral pontine infarcts as the initial presentation, with no inciting events and antiphospholipid antibodies were negative during the acute illness.https://actamedindones.org/index.php/ijim/article/view/1427antiphospholipid syndromecatastrophic aplsinfarctthrombosiscyclophosphamide |
| spellingShingle | Rathika Rajah Rizna A Cader Pontine Infarct as Initial Presentation of Catastrophic Antiphospholipid Syndrome in Systemic Lupus Erythematous Acta Medica Indonesiana antiphospholipid syndrome catastrophic apls infarct thrombosis cyclophosphamide |
| title | Pontine Infarct as Initial Presentation of Catastrophic Antiphospholipid Syndrome in Systemic Lupus Erythematous |
| title_full | Pontine Infarct as Initial Presentation of Catastrophic Antiphospholipid Syndrome in Systemic Lupus Erythematous |
| title_fullStr | Pontine Infarct as Initial Presentation of Catastrophic Antiphospholipid Syndrome in Systemic Lupus Erythematous |
| title_full_unstemmed | Pontine Infarct as Initial Presentation of Catastrophic Antiphospholipid Syndrome in Systemic Lupus Erythematous |
| title_short | Pontine Infarct as Initial Presentation of Catastrophic Antiphospholipid Syndrome in Systemic Lupus Erythematous |
| title_sort | pontine infarct as initial presentation of catastrophic antiphospholipid syndrome in systemic lupus erythematous |
| topic | antiphospholipid syndrome catastrophic apls infarct thrombosis cyclophosphamide |
| url | https://actamedindones.org/index.php/ijim/article/view/1427 |
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