MIC-Net: multi-scale integrated context network for automatic retinal vessel segmentation in fundus image

Purpose: Accurate retinal vessel segmentation is of great value in the auxiliary screening of various diseases. However, due to the low contrast between the ends of the branches of the fundus blood vessels and the background, and the variable morphology of the optic disc and cup in the retinal imag...

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Main Authors: Jinke Wang, Lubiao Zhou, Zhongzheng Yuan, Haiying Wang, Changfa Shi
Format: Article
Language:English
Published: AIMS Press 2023-02-01
Series:Mathematical Biosciences and Engineering
Subjects:
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2023298?viewType=HTML
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author Jinke Wang
Lubiao Zhou
Zhongzheng Yuan
Haiying Wang
Changfa Shi
author_facet Jinke Wang
Lubiao Zhou
Zhongzheng Yuan
Haiying Wang
Changfa Shi
author_sort Jinke Wang
collection DOAJ
description Purpose: Accurate retinal vessel segmentation is of great value in the auxiliary screening of various diseases. However, due to the low contrast between the ends of the branches of the fundus blood vessels and the background, and the variable morphology of the optic disc and cup in the retinal image, the task of high-precision retinal blood vessel segmentation still faces difficulties. Method: This paper proposes a multi-scale integrated context network, MIC-Net, which fully fuses the encoder-decoder features, and extracts multi-scale information. First, a hybrid stride sampling (HSS) block was designed in the encoder to minimize the loss of helpful information caused by the downsampling operation. Second, a dense hybrid dilated convolution (DHDC) was employed in the connection layer. On the premise of preserving feature resolution, it can perceive richer contextual information. Third, a squeeze-and-excitation with residual connections (SERC) was introduced in the decoder to adjust the channel attention adaptively. Finally, we utilized a multi-layer feature fusion mechanism in the skip connection part, which enables the network to consider both low-level details and high-level semantic information. Results: We evaluated the proposed method on three public datasets DRIVE, STARE and CHASE. In the experimental results, the Area under the receiver operating characteristic (ROC) and the accuracy rate (Acc) achieved high performances of 98.62%/97.02%, 98.60%/97.76% and 98.73%/97.38%, respectively. Conclusions: Experimental results show that the proposed method can obtain comparable segmentation performance compared with the state-of-the-art (SOTA) methods. Specifically, the proposed method can effectively reduce the small blood vessel segmentation error, thus proving it a promising tool for auxiliary diagnosis of ophthalmic diseases.
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spelling doaj.art-478f2b5e95c643dbbbe7edaac208e46d2023-03-01T01:16:47ZengAIMS PressMathematical Biosciences and Engineering1551-00182023-02-012046912693110.3934/mbe.2023298MIC-Net: multi-scale integrated context network for automatic retinal vessel segmentation in fundus imageJinke Wang0Lubiao Zhou1Zhongzheng Yuan 2Haiying Wang3Changfa Shi41. Department of Software Engineering, Harbin University of Science and Technology, Rongcheng 264300, China 2. School of Automation, Harbin University of Science and Technology, Harbin 150080, China2. School of Automation, Harbin University of Science and Technology, Harbin 150080, China1. Department of Software Engineering, Harbin University of Science and Technology, Rongcheng 264300, China2. School of Automation, Harbin University of Science and Technology, Harbin 150080, China3. Mobile E-business Collaborative Innovation Center of Hunan Province, Hunan University of Technology and Business, Changsha 410205, ChinaPurpose: Accurate retinal vessel segmentation is of great value in the auxiliary screening of various diseases. However, due to the low contrast between the ends of the branches of the fundus blood vessels and the background, and the variable morphology of the optic disc and cup in the retinal image, the task of high-precision retinal blood vessel segmentation still faces difficulties. Method: This paper proposes a multi-scale integrated context network, MIC-Net, which fully fuses the encoder-decoder features, and extracts multi-scale information. First, a hybrid stride sampling (HSS) block was designed in the encoder to minimize the loss of helpful information caused by the downsampling operation. Second, a dense hybrid dilated convolution (DHDC) was employed in the connection layer. On the premise of preserving feature resolution, it can perceive richer contextual information. Third, a squeeze-and-excitation with residual connections (SERC) was introduced in the decoder to adjust the channel attention adaptively. Finally, we utilized a multi-layer feature fusion mechanism in the skip connection part, which enables the network to consider both low-level details and high-level semantic information. Results: We evaluated the proposed method on three public datasets DRIVE, STARE and CHASE. In the experimental results, the Area under the receiver operating characteristic (ROC) and the accuracy rate (Acc) achieved high performances of 98.62%/97.02%, 98.60%/97.76% and 98.73%/97.38%, respectively. Conclusions: Experimental results show that the proposed method can obtain comparable segmentation performance compared with the state-of-the-art (SOTA) methods. Specifically, the proposed method can effectively reduce the small blood vessel segmentation error, thus proving it a promising tool for auxiliary diagnosis of ophthalmic diseases.https://www.aimspress.com/article/doi/10.3934/mbe.2023298?viewType=HTMLretinal vessel segmentationfundus imagemulti-scaledeep learning
spellingShingle Jinke Wang
Lubiao Zhou
Zhongzheng Yuan
Haiying Wang
Changfa Shi
MIC-Net: multi-scale integrated context network for automatic retinal vessel segmentation in fundus image
Mathematical Biosciences and Engineering
retinal vessel segmentation
fundus image
multi-scale
deep learning
title MIC-Net: multi-scale integrated context network for automatic retinal vessel segmentation in fundus image
title_full MIC-Net: multi-scale integrated context network for automatic retinal vessel segmentation in fundus image
title_fullStr MIC-Net: multi-scale integrated context network for automatic retinal vessel segmentation in fundus image
title_full_unstemmed MIC-Net: multi-scale integrated context network for automatic retinal vessel segmentation in fundus image
title_short MIC-Net: multi-scale integrated context network for automatic retinal vessel segmentation in fundus image
title_sort mic net multi scale integrated context network for automatic retinal vessel segmentation in fundus image
topic retinal vessel segmentation
fundus image
multi-scale
deep learning
url https://www.aimspress.com/article/doi/10.3934/mbe.2023298?viewType=HTML
work_keys_str_mv AT jinkewang micnetmultiscaleintegratedcontextnetworkforautomaticretinalvesselsegmentationinfundusimage
AT lubiaozhou micnetmultiscaleintegratedcontextnetworkforautomaticretinalvesselsegmentationinfundusimage
AT zhongzhengyuan micnetmultiscaleintegratedcontextnetworkforautomaticretinalvesselsegmentationinfundusimage
AT haiyingwang micnetmultiscaleintegratedcontextnetworkforautomaticretinalvesselsegmentationinfundusimage
AT changfashi micnetmultiscaleintegratedcontextnetworkforautomaticretinalvesselsegmentationinfundusimage