Potential Inhibitory Effect of Miltefosine against Terbinafine-Resistant <i>Trichophyton indotineae</i>
Several prolonged and significant outbreaks of dermatophytosis caused by <i>Trichophyton indotineae</i>, a new emerging terbinafine-resistant species, have been ongoing in India in recent years, and have since spread to various countries outside Asia. Miltefosine, an alkylphosphocholine,...
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MDPI AG
2023-04-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/4/606 |
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| author | Iman Haghani Javad Akhtari Zahra Yahyazadeh Amirreza Espahbodi Firoozeh Kermani Javad Javidnia Mohammad Taghi Hedayati Tahereh Shokohi Hamid Badali Ali Rezaei-Matehkolaei Seyed Reza Aghili Ahmed Al-Rawahi Ahmed Al-Harrasi Mahdi Abastabar Abdullah M. S. Al-Hatmi |
| author_facet | Iman Haghani Javad Akhtari Zahra Yahyazadeh Amirreza Espahbodi Firoozeh Kermani Javad Javidnia Mohammad Taghi Hedayati Tahereh Shokohi Hamid Badali Ali Rezaei-Matehkolaei Seyed Reza Aghili Ahmed Al-Rawahi Ahmed Al-Harrasi Mahdi Abastabar Abdullah M. S. Al-Hatmi |
| author_sort | Iman Haghani |
| collection | DOAJ |
| description | Several prolonged and significant outbreaks of dermatophytosis caused by <i>Trichophyton indotineae</i>, a new emerging terbinafine-resistant species, have been ongoing in India in recent years, and have since spread to various countries outside Asia. Miltefosine, an alkylphosphocholine, is the most recently approved drug for the treatment of both visceral and cutaneous leishmaniasis. Miltefosine in vitro activity against terbinafine-resistant and susceptible <i>T. mentagrophytes</i>/<i>T. interdigitale</i> species complex, including <i>T. indotineae</i>, is limited. The current study aimed to assess miltefosine’s in vitro activity against dermatophyte isolates, which are the most common causes of dermatophytosis. Miltefosine, terbinafine, butenafine, tolnaftate, and itraconazole susceptibility testing was performed using Clinical and Laboratory Standards Institute broth microdilution methods (CLSI M38-A3) against 40 terbinafine-resistant <i>T. indotineae</i> isolates and 40 terbinafine-susceptible <i>T. mentagrophytes</i>/<i>T. interdigitale</i> species complex isolates. Miltefosine had MIC ranges of 0.063–0.5 µg/mL and 0.125–0.25 µg/mL against both terbinafine-resistant and susceptible isolates. In terbinafine-resistant isolates, the MIC<sub>50</sub> and MIC<sub>90</sub> were 0.125 µg/mL and 0.25 µg/mL, respectively, and 0.25 µg/mL in susceptible isolates. Miltefosine had statistically significant differences in MIC results when compared to other antifungal agents (<i>p</i>-value 0.05) in terbinafine-resistant strains. Accordingly, the findings suggest that miltefosine has a potential activity for treating infections caused by terbinafine-resistant <i>T. indotineae.</i> However, further studies are needed to determine how well this in vitro activity translates into in vivo efficacy. |
| first_indexed | 2024-03-11T04:39:11Z |
| format | Article |
| id | doaj.art-47910af359264897a1ca3dc757b3149b |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-11T04:39:11Z |
| publishDate | 2023-04-01 |
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| series | Pathogens |
| spelling | doaj.art-47910af359264897a1ca3dc757b3149b2023-11-17T20:49:07ZengMDPI AGPathogens2076-08172023-04-0112460610.3390/pathogens12040606Potential Inhibitory Effect of Miltefosine against Terbinafine-Resistant <i>Trichophyton indotineae</i>Iman Haghani0Javad Akhtari1Zahra Yahyazadeh2Amirreza Espahbodi3Firoozeh Kermani4Javad Javidnia5Mohammad Taghi Hedayati6Tahereh Shokohi7Hamid Badali8Ali Rezaei-Matehkolaei9Seyed Reza Aghili10Ahmed Al-Rawahi11Ahmed Al-Harrasi12Mahdi Abastabar13Abdullah M. S. Al-Hatmi14Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, IranImmunogenetics Research Center, Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, IranDepartment of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, IranStudent Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, IranInvasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, IranInvasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, IranInvasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, IranInvasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, IranInvasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, IranDepartment of Medical Mycology, School of Medicine, Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, IranInvasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, IranNatural & Medical Sciences Research Centre, University of Nizwa, Nizwa 616, OmanNatural & Medical Sciences Research Centre, University of Nizwa, Nizwa 616, OmanInvasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, IranNatural & Medical Sciences Research Centre, University of Nizwa, Nizwa 616, OmanSeveral prolonged and significant outbreaks of dermatophytosis caused by <i>Trichophyton indotineae</i>, a new emerging terbinafine-resistant species, have been ongoing in India in recent years, and have since spread to various countries outside Asia. Miltefosine, an alkylphosphocholine, is the most recently approved drug for the treatment of both visceral and cutaneous leishmaniasis. Miltefosine in vitro activity against terbinafine-resistant and susceptible <i>T. mentagrophytes</i>/<i>T. interdigitale</i> species complex, including <i>T. indotineae</i>, is limited. The current study aimed to assess miltefosine’s in vitro activity against dermatophyte isolates, which are the most common causes of dermatophytosis. Miltefosine, terbinafine, butenafine, tolnaftate, and itraconazole susceptibility testing was performed using Clinical and Laboratory Standards Institute broth microdilution methods (CLSI M38-A3) against 40 terbinafine-resistant <i>T. indotineae</i> isolates and 40 terbinafine-susceptible <i>T. mentagrophytes</i>/<i>T. interdigitale</i> species complex isolates. Miltefosine had MIC ranges of 0.063–0.5 µg/mL and 0.125–0.25 µg/mL against both terbinafine-resistant and susceptible isolates. In terbinafine-resistant isolates, the MIC<sub>50</sub> and MIC<sub>90</sub> were 0.125 µg/mL and 0.25 µg/mL, respectively, and 0.25 µg/mL in susceptible isolates. Miltefosine had statistically significant differences in MIC results when compared to other antifungal agents (<i>p</i>-value 0.05) in terbinafine-resistant strains. Accordingly, the findings suggest that miltefosine has a potential activity for treating infections caused by terbinafine-resistant <i>T. indotineae.</i> However, further studies are needed to determine how well this in vitro activity translates into in vivo efficacy.https://www.mdpi.com/2076-0817/12/4/606miltefosine<i>T. mentagrophytes</i><i>T. interdigitale</i><i>T. indotineae</i>terbinafine |
| spellingShingle | Iman Haghani Javad Akhtari Zahra Yahyazadeh Amirreza Espahbodi Firoozeh Kermani Javad Javidnia Mohammad Taghi Hedayati Tahereh Shokohi Hamid Badali Ali Rezaei-Matehkolaei Seyed Reza Aghili Ahmed Al-Rawahi Ahmed Al-Harrasi Mahdi Abastabar Abdullah M. S. Al-Hatmi Potential Inhibitory Effect of Miltefosine against Terbinafine-Resistant <i>Trichophyton indotineae</i> Pathogens miltefosine <i>T. mentagrophytes</i> <i>T. interdigitale</i> <i>T. indotineae</i> terbinafine |
| title | Potential Inhibitory Effect of Miltefosine against Terbinafine-Resistant <i>Trichophyton indotineae</i> |
| title_full | Potential Inhibitory Effect of Miltefosine against Terbinafine-Resistant <i>Trichophyton indotineae</i> |
| title_fullStr | Potential Inhibitory Effect of Miltefosine against Terbinafine-Resistant <i>Trichophyton indotineae</i> |
| title_full_unstemmed | Potential Inhibitory Effect of Miltefosine against Terbinafine-Resistant <i>Trichophyton indotineae</i> |
| title_short | Potential Inhibitory Effect of Miltefosine against Terbinafine-Resistant <i>Trichophyton indotineae</i> |
| title_sort | potential inhibitory effect of miltefosine against terbinafine resistant i trichophyton indotineae i |
| topic | miltefosine <i>T. mentagrophytes</i> <i>T. interdigitale</i> <i>T. indotineae</i> terbinafine |
| url | https://www.mdpi.com/2076-0817/12/4/606 |
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