Diverse molecular functions of m6A mRNA modification in cancer
Cancer: monitoring messenger RNA modifications A thorough investigation into the role and function of RNA modifications in cancers could yield novel therapies. The chemical modification of messenger RNA (mRNA), the molecule that carries code from DNA to synthesize proteins, is thought to play a role...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-05-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-0432-y |
| _version_ | 1818453683733528576 |
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| author | Seung Hun Han Junho Choe |
| author_facet | Seung Hun Han Junho Choe |
| author_sort | Seung Hun Han |
| collection | DOAJ |
| description | Cancer: monitoring messenger RNA modifications A thorough investigation into the role and function of RNA modifications in cancers could yield novel therapies. The chemical modification of messenger RNA (mRNA), the molecule that carries code from DNA to synthesize proteins, is thought to play a role in influencing genetically inherited traits and diseases. A common modification found in mRNA is N 6-methyladenosine (m6A). Disruption to the regulation of m6A modification has been linked with human cancers. Junho Choe and Seung Hun Han at Hanyang University in Seoul, South Korea, reviewed current understanding of the molecular mechanisms behind m6A modification, with particular reference to tumor formation. The researchers point out that abnormal expression of proteins associated with m6A may lead to heightened expression of cancer-related genes. More extensive m6A modification levels are also linked to tumor formation. |
| first_indexed | 2024-12-14T21:42:53Z |
| format | Article |
| id | doaj.art-479175f3ede14f6183195e0253eb8d42 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-14T21:42:53Z |
| publishDate | 2020-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-479175f3ede14f6183195e0253eb8d422022-12-21T22:46:24ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-05-0152573874910.1038/s12276-020-0432-yDiverse molecular functions of m6A mRNA modification in cancerSeung Hun Han0Junho Choe1Department of Life Science, College of Natural Sciences, Hanyang UniversityDepartment of Life Science, College of Natural Sciences, Hanyang UniversityCancer: monitoring messenger RNA modifications A thorough investigation into the role and function of RNA modifications in cancers could yield novel therapies. The chemical modification of messenger RNA (mRNA), the molecule that carries code from DNA to synthesize proteins, is thought to play a role in influencing genetically inherited traits and diseases. A common modification found in mRNA is N 6-methyladenosine (m6A). Disruption to the regulation of m6A modification has been linked with human cancers. Junho Choe and Seung Hun Han at Hanyang University in Seoul, South Korea, reviewed current understanding of the molecular mechanisms behind m6A modification, with particular reference to tumor formation. The researchers point out that abnormal expression of proteins associated with m6A may lead to heightened expression of cancer-related genes. More extensive m6A modification levels are also linked to tumor formation.https://doi.org/10.1038/s12276-020-0432-y |
| spellingShingle | Seung Hun Han Junho Choe Diverse molecular functions of m6A mRNA modification in cancer Experimental and Molecular Medicine |
| title | Diverse molecular functions of m6A mRNA modification in cancer |
| title_full | Diverse molecular functions of m6A mRNA modification in cancer |
| title_fullStr | Diverse molecular functions of m6A mRNA modification in cancer |
| title_full_unstemmed | Diverse molecular functions of m6A mRNA modification in cancer |
| title_short | Diverse molecular functions of m6A mRNA modification in cancer |
| title_sort | diverse molecular functions of m6a mrna modification in cancer |
| url | https://doi.org/10.1038/s12276-020-0432-y |
| work_keys_str_mv | AT seunghunhan diversemolecularfunctionsofm6amrnamodificationincancer AT junhochoe diversemolecularfunctionsofm6amrnamodificationincancer |