Cellular senescence contributes to mechanical ventilation-induced diaphragm dysfunction by upregulating p53 signalling pathways

Cellular senescence contributes to mechanical ventilation-induced diaphragm dysfunction by upregulating p53 signalling pathways

Abstract Background Mechanical ventilation can cause acute atrophy and injury in the diaphragm, which are related to adverse clinical results. However, the underlying mechanisms of ventilation-induced diaphragm dysfunction (VIDD) have not been well elucidated. The current study aimed to explore the...

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Bibliographic Details
Main Authors: Weimin Shen, Ye Jiang, Ying Xu, Xiaoli Qian, Jianwei Jia, Yuejia Ding, Yuhan He, Qing Pan, Jinyang Zhuang, Huiqing Ge, Peifeng Xu
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Pulmonary Medicine
Subjects:
Mechanical ventilation
Diaphragm dysfunction
Cellular senescence
p53-p21 axis
Online Access:https://doi.org/10.1186/s12890-023-02662-7

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