Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes
Approximately, 35% of women with Gestational Diabetes (GDM) progress to Type 2 Diabetes (T2D) within 10 years. However, links between GDM and T2D are not well understood. We used a well-characterised GDM prospective cohort of 1035 women following up to 8 years postpartum. Lipidomics profiling coveri...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/59153 |
| _version_ | 1797991958315008000 |
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| author | Mi Lai Dana Al Rijjal Hannes L Röst Feihan F Dai Erica P Gunderson Michael B Wheeler |
| author_facet | Mi Lai Dana Al Rijjal Hannes L Röst Feihan F Dai Erica P Gunderson Michael B Wheeler |
| author_sort | Mi Lai |
| collection | DOAJ |
| description | Approximately, 35% of women with Gestational Diabetes (GDM) progress to Type 2 Diabetes (T2D) within 10 years. However, links between GDM and T2D are not well understood. We used a well-characterised GDM prospective cohort of 1035 women following up to 8 years postpartum. Lipidomics profiling covering >1000 lipids was performed on fasting plasma samples from participants 6–9 week postpartum (171 incident T2D vs. 179 controls). We discovered 311 lipids positively and 70 lipids negatively associated with T2D risk. The upregulation of glycerolipid metabolism involving triacylglycerol and diacylglycerol biosynthesis suggested activated lipid storage before diabetes onset. In contrast, decreased sphingomyelines, hexosylceramide and lactosylceramide indicated impaired sphingolipid metabolism. Additionally, a lipid signature was identified to effectively predict future diabetes risk. These findings demonstrate an underlying dyslipidemia during the early postpartum in those GDM women who progress to T2D and suggest endogenous lipogenesis may be a driving force for future diabetes onset. |
| first_indexed | 2024-04-11T09:00:24Z |
| format | Article |
| id | doaj.art-4795b0d92c894aa1af5cabc1a7ba37e0 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:00:24Z |
| publishDate | 2020-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-4795b0d92c894aa1af5cabc1a7ba37e02022-12-22T04:32:48ZengeLife Sciences Publications LtdeLife2050-084X2020-08-01910.7554/eLife.59153Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetesMi Lai0Dana Al Rijjal1Hannes L Röst2Feihan F Dai3Erica P Gunderson4Michael B Wheeler5https://orcid.org/0000-0002-7480-7267Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, CanadaDepartment of Physiology, Faculty of Medicine, University of Toronto, Ontario, CanadaDonnelly Centre for Cellular & Biomolecular Research, University of Toronto, Ontario, CanadaDepartment of Physiology, Faculty of Medicine, University of Toronto, Ontario, CanadaKaiser Permanente Northern California, Division of Research, Oakland, United StatesDepartment of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada; Advanced Diagnostics, Metabolism, Toronto General Research Institute, Ontario, CanadaApproximately, 35% of women with Gestational Diabetes (GDM) progress to Type 2 Diabetes (T2D) within 10 years. However, links between GDM and T2D are not well understood. We used a well-characterised GDM prospective cohort of 1035 women following up to 8 years postpartum. Lipidomics profiling covering >1000 lipids was performed on fasting plasma samples from participants 6–9 week postpartum (171 incident T2D vs. 179 controls). We discovered 311 lipids positively and 70 lipids negatively associated with T2D risk. The upregulation of glycerolipid metabolism involving triacylglycerol and diacylglycerol biosynthesis suggested activated lipid storage before diabetes onset. In contrast, decreased sphingomyelines, hexosylceramide and lactosylceramide indicated impaired sphingolipid metabolism. Additionally, a lipid signature was identified to effectively predict future diabetes risk. These findings demonstrate an underlying dyslipidemia during the early postpartum in those GDM women who progress to T2D and suggest endogenous lipogenesis may be a driving force for future diabetes onset.https://elifesciences.org/articles/59153Gestational diabetes mellitusprospective studypathophysiologylipidomicsType 2 Diabetes |
| spellingShingle | Mi Lai Dana Al Rijjal Hannes L Röst Feihan F Dai Erica P Gunderson Michael B Wheeler Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes eLife Gestational diabetes mellitus prospective study pathophysiology lipidomics Type 2 Diabetes |
| title | Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes |
| title_full | Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes |
| title_fullStr | Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes |
| title_full_unstemmed | Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes |
| title_short | Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes |
| title_sort | underlying dyslipidemia postpartum in women with a recent gdm pregnancy who develop type 2 diabetes |
| topic | Gestational diabetes mellitus prospective study pathophysiology lipidomics Type 2 Diabetes |
| url | https://elifesciences.org/articles/59153 |
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