Time-dependent change of relative apical longitudinal strain index in patients with wild-type transthyretin amyloid cardiomyopathy
Aim: This study was conducted to investigate the meaning of left ventricular (LV) apical sparing in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). Methods and results: 165 patients who were diagnosed with ATTRwt-CM at Kumamoto University Hospital from January 2002 to Decem...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906722001956 |
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| author | Hiroki Usuku Eiichiro Yamamoto Daisuke Sueta Momoko Noguchi Tomohiro Fujisaki Koichi Egashira Mami Morioka Takashi Komorita Fumi Oike Koichiro Fujisue Shinsuke Hanatani Yuichiro Arima Seiji Takashio Seitaro Oda Hiroaki Kawano Kenichi Matsushita Mitsuharu Ueda Hirotaka Matsui Kenichi Tsujita |
| author_facet | Hiroki Usuku Eiichiro Yamamoto Daisuke Sueta Momoko Noguchi Tomohiro Fujisaki Koichi Egashira Mami Morioka Takashi Komorita Fumi Oike Koichiro Fujisue Shinsuke Hanatani Yuichiro Arima Seiji Takashio Seitaro Oda Hiroaki Kawano Kenichi Matsushita Mitsuharu Ueda Hirotaka Matsui Kenichi Tsujita |
| author_sort | Hiroki Usuku |
| collection | DOAJ |
| description | Aim: This study was conducted to investigate the meaning of left ventricular (LV) apical sparing in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). Methods and results: 165 patients who were diagnosed with ATTRwt-CM at Kumamoto University Hospital from January 2002 to December 2020 and had sufficient data for two-dimensional speckle tracking echocardiography were enrolled. Of these, 86 patients (52 %) had LV apical sparing (relative apical longitudinal strain index (RapLSI) > 1.0). Multivariable logistic regression analysis revealed the following variables were significantly associated with LV apical sparing: interventricular septal thickness in diastole (odds ratio (OR), 1.19; 95 % confidence interval (CI), 1.01–1.41; p < 0.05); E/e’ ratio (OR, 1.06; 95 % CI, 1.00–1.11; p < 0.05); and heart-to-contralateral ratio by 99mTc-labeled pyrophosphate scintigraphy (OR, 3.40; 95 % CI, 1.07–10.83; p < 0.05).Next, we compared RapLSI at the time of diagnosis with that during the follow-up period (396 days (346–458) after diagnosis) in 92 patients. RapLSI increased significantly during the follow-up period compared with RapLSI at diagnosis in the non-LV apical sparing group (0.89 ± 0.32 vs 0.74 ± 0.18, p < 0.01) but not in the LV apical sparing group (1.33 ± 0.53 vs 1.39 ± 0.45, p = 0.46). A total of 12 patients (29 %) in the non-LV apical sparing group developed LV apical sparing and 11 patients (22 %) in LV apical sparing group diminished LV apical sparing during the follow-up period. Conclusion: Approximately half of ATTRwt-CM patients did not have LV apical sparing at diagnosis. Because RapLSI in ATTRwt-CM significantly changed over time, repeated two-dimensional speckle tracking analysis is important for suspected ATTR-CM patients. |
| first_indexed | 2024-04-13T05:29:16Z |
| format | Article |
| id | doaj.art-47962fd2984349f9bf8076aa71c3a5ba |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-13T05:29:16Z |
| publishDate | 2022-12-01 |
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| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-47962fd2984349f9bf8076aa71c3a5ba2022-12-22T03:00:29ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672022-12-0143101146Time-dependent change of relative apical longitudinal strain index in patients with wild-type transthyretin amyloid cardiomyopathyHiroki Usuku0Eiichiro Yamamoto1Daisuke Sueta2Momoko Noguchi3Tomohiro Fujisaki4Koichi Egashira5Mami Morioka6Takashi Komorita7Fumi Oike8Koichiro Fujisue9Shinsuke Hanatani10Yuichiro Arima11Seiji Takashio12Seitaro Oda13Hiroaki Kawano14Kenichi Matsushita15Mitsuharu Ueda16Hirotaka Matsui17Kenichi Tsujita18Department of Laboratory Medicine, Kumamoto University Hospital, Kumamoto, Japan; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, Japan; Corresponding author at: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Laboratory Medicine, Kumamoto University Hospital, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, Japan; Division of Advanced Cardiovascular Therapeutics, Kumamoto University Hospital, Kumamoto, JapanCenter of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, Japan; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Molecular Laboratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University, Faculty of Life Sciences, Kumamoto, JapanAim: This study was conducted to investigate the meaning of left ventricular (LV) apical sparing in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). Methods and results: 165 patients who were diagnosed with ATTRwt-CM at Kumamoto University Hospital from January 2002 to December 2020 and had sufficient data for two-dimensional speckle tracking echocardiography were enrolled. Of these, 86 patients (52 %) had LV apical sparing (relative apical longitudinal strain index (RapLSI) > 1.0). Multivariable logistic regression analysis revealed the following variables were significantly associated with LV apical sparing: interventricular septal thickness in diastole (odds ratio (OR), 1.19; 95 % confidence interval (CI), 1.01–1.41; p < 0.05); E/e’ ratio (OR, 1.06; 95 % CI, 1.00–1.11; p < 0.05); and heart-to-contralateral ratio by 99mTc-labeled pyrophosphate scintigraphy (OR, 3.40; 95 % CI, 1.07–10.83; p < 0.05).Next, we compared RapLSI at the time of diagnosis with that during the follow-up period (396 days (346–458) after diagnosis) in 92 patients. RapLSI increased significantly during the follow-up period compared with RapLSI at diagnosis in the non-LV apical sparing group (0.89 ± 0.32 vs 0.74 ± 0.18, p < 0.01) but not in the LV apical sparing group (1.33 ± 0.53 vs 1.39 ± 0.45, p = 0.46). A total of 12 patients (29 %) in the non-LV apical sparing group developed LV apical sparing and 11 patients (22 %) in LV apical sparing group diminished LV apical sparing during the follow-up period. Conclusion: Approximately half of ATTRwt-CM patients did not have LV apical sparing at diagnosis. Because RapLSI in ATTRwt-CM significantly changed over time, repeated two-dimensional speckle tracking analysis is important for suspected ATTR-CM patients.http://www.sciencedirect.com/science/article/pii/S2352906722001956Wild-type transthyretin amyloid cardiomyopathyEchocardiographyTwo-dimensional speckle tracking echocardiographyLongitudinal strainLeft ventricular apical sparing |
| spellingShingle | Hiroki Usuku Eiichiro Yamamoto Daisuke Sueta Momoko Noguchi Tomohiro Fujisaki Koichi Egashira Mami Morioka Takashi Komorita Fumi Oike Koichiro Fujisue Shinsuke Hanatani Yuichiro Arima Seiji Takashio Seitaro Oda Hiroaki Kawano Kenichi Matsushita Mitsuharu Ueda Hirotaka Matsui Kenichi Tsujita Time-dependent change of relative apical longitudinal strain index in patients with wild-type transthyretin amyloid cardiomyopathy International Journal of Cardiology: Heart & Vasculature Wild-type transthyretin amyloid cardiomyopathy Echocardiography Two-dimensional speckle tracking echocardiography Longitudinal strain Left ventricular apical sparing |
| title | Time-dependent change of relative apical longitudinal strain index in patients with wild-type transthyretin amyloid cardiomyopathy |
| title_full | Time-dependent change of relative apical longitudinal strain index in patients with wild-type transthyretin amyloid cardiomyopathy |
| title_fullStr | Time-dependent change of relative apical longitudinal strain index in patients with wild-type transthyretin amyloid cardiomyopathy |
| title_full_unstemmed | Time-dependent change of relative apical longitudinal strain index in patients with wild-type transthyretin amyloid cardiomyopathy |
| title_short | Time-dependent change of relative apical longitudinal strain index in patients with wild-type transthyretin amyloid cardiomyopathy |
| title_sort | time dependent change of relative apical longitudinal strain index in patients with wild type transthyretin amyloid cardiomyopathy |
| topic | Wild-type transthyretin amyloid cardiomyopathy Echocardiography Two-dimensional speckle tracking echocardiography Longitudinal strain Left ventricular apical sparing |
| url | http://www.sciencedirect.com/science/article/pii/S2352906722001956 |
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