Low Measles Seropositivity Rate among Thai Adolescents in the Thai National Immunization Program
To achieve the goal of measles elimination, herd immunity with 95% seroprotection in the community is required. This study aimed to describe the measles seropositivity rate among Thai children and adolescents. A cross-sectional study was conducted among children aged 3–18 years in Bangkok and its su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/8/1269 |
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| author | Thanyawee Puthanakit Suvaporn Anugulruengkitt Piyada Angsuwatcharakon Pornumpa Bunjoungmanee Ekasit Kowitdamrong Athiwat Primsirikunawut Sukkrawan Intarakhao Panadda Chetsonwisorn Jiratchaya Sophonphan Auchara Tangsathapornpong |
| author_facet | Thanyawee Puthanakit Suvaporn Anugulruengkitt Piyada Angsuwatcharakon Pornumpa Bunjoungmanee Ekasit Kowitdamrong Athiwat Primsirikunawut Sukkrawan Intarakhao Panadda Chetsonwisorn Jiratchaya Sophonphan Auchara Tangsathapornpong |
| author_sort | Thanyawee Puthanakit |
| collection | DOAJ |
| description | To achieve the goal of measles elimination, herd immunity with 95% seroprotection in the community is required. This study aimed to describe the measles seropositivity rate among Thai children and adolescents. A cross-sectional study was conducted among children aged 3–18 years in Bangkok and its suburbs. Measles IgG antibodies were measured using a EUROIMMUN enzyme-linked immunosorbent assay kit. Seropositivity is defined as a measles IgG titer of ≥200 IU/L, due to a correlation with a >85% positive rate with a plaque reduction neutralizing titer of >120. Factors associated with seropositivity were analyzed using logistic regression analysis. From May to July 2020, 570 children with a median (IQR) age of 11.7 (9.4–14.8) years were enrolled. The geometric mean titer (GMT) of anti-measles IgG was 281 IU/L (95% CI; 257–306). The proportion of children with seropositivity was inversely correlated with age; 3–5 years 85.3%, 6–9 years 72.5%, 10–14 years 50.7%, and 15–18 years 56.3%. Adolescents aged 10–18 years had a lower measles seropositivity rate compared with young children; aOR 0.29 (95% CI 0.17–0.48). Only half of the adolescents who received two doses of measles-containing vaccine maintained measles IgG above the seropositive level. A measles booster dose for young adults may be needed to achieve the measles elimination goal. |
| first_indexed | 2024-03-09T12:23:35Z |
| format | Article |
| id | doaj.art-47991700330146f985a01f8ff0c3bc02 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:23:35Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-47991700330146f985a01f8ff0c3bc022023-11-30T22:37:15ZengMDPI AGVaccines2076-393X2022-08-01108126910.3390/vaccines10081269Low Measles Seropositivity Rate among Thai Adolescents in the Thai National Immunization ProgramThanyawee Puthanakit0Suvaporn Anugulruengkitt1Piyada Angsuwatcharakon2Pornumpa Bunjoungmanee3Ekasit Kowitdamrong4Athiwat Primsirikunawut5Sukkrawan Intarakhao6Panadda Chetsonwisorn7Jiratchaya Sophonphan8Auchara Tangsathapornpong9Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandDivision of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Diseases Control, Ministry of Public Health, Nonthaburi 11000, ThailandDivision of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani 12120, ThailandDivision of Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandNational Institute of Thailand, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, ThailandDivision of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani 12120, ThailandCenter of Excellence for Pediatric Infectious Diseases and Vaccines, Chulalongkorn University, Bangkok 10330, ThailandCenter of Excellence for Pediatric Infectious Diseases and Vaccines, Chulalongkorn University, Bangkok 10330, ThailandDivision of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani 12120, ThailandTo achieve the goal of measles elimination, herd immunity with 95% seroprotection in the community is required. This study aimed to describe the measles seropositivity rate among Thai children and adolescents. A cross-sectional study was conducted among children aged 3–18 years in Bangkok and its suburbs. Measles IgG antibodies were measured using a EUROIMMUN enzyme-linked immunosorbent assay kit. Seropositivity is defined as a measles IgG titer of ≥200 IU/L, due to a correlation with a >85% positive rate with a plaque reduction neutralizing titer of >120. Factors associated with seropositivity were analyzed using logistic regression analysis. From May to July 2020, 570 children with a median (IQR) age of 11.7 (9.4–14.8) years were enrolled. The geometric mean titer (GMT) of anti-measles IgG was 281 IU/L (95% CI; 257–306). The proportion of children with seropositivity was inversely correlated with age; 3–5 years 85.3%, 6–9 years 72.5%, 10–14 years 50.7%, and 15–18 years 56.3%. Adolescents aged 10–18 years had a lower measles seropositivity rate compared with young children; aOR 0.29 (95% CI 0.17–0.48). Only half of the adolescents who received two doses of measles-containing vaccine maintained measles IgG above the seropositive level. A measles booster dose for young adults may be needed to achieve the measles elimination goal.https://www.mdpi.com/2076-393X/10/8/1269seroprevalencemeasleschildrenadolescentsThai |
| spellingShingle | Thanyawee Puthanakit Suvaporn Anugulruengkitt Piyada Angsuwatcharakon Pornumpa Bunjoungmanee Ekasit Kowitdamrong Athiwat Primsirikunawut Sukkrawan Intarakhao Panadda Chetsonwisorn Jiratchaya Sophonphan Auchara Tangsathapornpong Low Measles Seropositivity Rate among Thai Adolescents in the Thai National Immunization Program Vaccines seroprevalence measles children adolescents Thai |
| title | Low Measles Seropositivity Rate among Thai Adolescents in the Thai National Immunization Program |
| title_full | Low Measles Seropositivity Rate among Thai Adolescents in the Thai National Immunization Program |
| title_fullStr | Low Measles Seropositivity Rate among Thai Adolescents in the Thai National Immunization Program |
| title_full_unstemmed | Low Measles Seropositivity Rate among Thai Adolescents in the Thai National Immunization Program |
| title_short | Low Measles Seropositivity Rate among Thai Adolescents in the Thai National Immunization Program |
| title_sort | low measles seropositivity rate among thai adolescents in the thai national immunization program |
| topic | seroprevalence measles children adolescents Thai |
| url | https://www.mdpi.com/2076-393X/10/8/1269 |
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