Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay....
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272072/?tool=EBI |
| _version_ | 1818573399196172288 |
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| author | Arantxa Palacín Cristina Gómez-Casado Luis A Rivas Jacobo Aguirre Leticia Tordesillas Joan Bartra Carlos Blanco Teresa Carrillo Javier Cuesta-Herranz Consolación de Frutos Genoveva García Alvarez-Eire Francisco J Fernández Pedro Gamboa Rosa Muñoz Rosa Sánchez-Monge Sofía Sirvent María J Torres Susana Varela-Losada Rosalía Rodríguez Victor Parro Miguel Blanca Gabriel Salcedo Araceli Díaz-Perales |
| author_facet | Arantxa Palacín Cristina Gómez-Casado Luis A Rivas Jacobo Aguirre Leticia Tordesillas Joan Bartra Carlos Blanco Teresa Carrillo Javier Cuesta-Herranz Consolación de Frutos Genoveva García Alvarez-Eire Francisco J Fernández Pedro Gamboa Rosa Muñoz Rosa Sánchez-Monge Sofía Sirvent María J Torres Susana Varela-Losada Rosalía Rodríguez Victor Parro Miguel Blanca Gabriel Salcedo Araceli Díaz-Perales |
| author_sort | Arantxa Palacín |
| collection | DOAJ |
| description | The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens. |
| first_indexed | 2024-12-15T00:10:36Z |
| format | Article |
| id | doaj.art-4799e3f956364258a6743aa015a6bfc4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-15T00:10:36Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4799e3f956364258a6743aa015a6bfc42022-12-21T22:42:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5079910.1371/journal.pone.0050799Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.Arantxa PalacínCristina Gómez-CasadoLuis A RivasJacobo AguirreLeticia TordesillasJoan BartraCarlos BlancoTeresa CarrilloJavier Cuesta-HerranzConsolación de FrutosGenoveva García Alvarez-EireFrancisco J FernándezPedro GamboaRosa MuñozRosa Sánchez-MongeSofía SirventMaría J TorresSusana Varela-LosadaRosalía RodríguezVictor ParroMiguel BlancaGabriel SalcedoAraceli Díaz-PeralesThe study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272072/?tool=EBI |
| spellingShingle | Arantxa Palacín Cristina Gómez-Casado Luis A Rivas Jacobo Aguirre Leticia Tordesillas Joan Bartra Carlos Blanco Teresa Carrillo Javier Cuesta-Herranz Consolación de Frutos Genoveva García Alvarez-Eire Francisco J Fernández Pedro Gamboa Rosa Muñoz Rosa Sánchez-Monge Sofía Sirvent María J Torres Susana Varela-Losada Rosalía Rodríguez Victor Parro Miguel Blanca Gabriel Salcedo Araceli Díaz-Perales Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. PLoS ONE |
| title | Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_full | Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_fullStr | Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_full_unstemmed | Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_short | Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_sort | graph based study of allergen cross reactivity of plant lipid transfer proteins ltps using microarray in a multicenter study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272072/?tool=EBI |
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