Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis
Background. Acute kidney injury (AKI) is a complex clinical syndrome of hospitalization that may be affected by undernutrition and metabolic changes. The aim of this meta-analysis was to systematically assess the association between malnutrition and the risk of prevalent AKI. Materials and Methods....
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| Format: | Article |
| Language: | English |
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Hindawi-Wiley
2023-01-01
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| Series: | International Journal of Clinical Practice |
| Online Access: | http://dx.doi.org/10.1155/2023/9910718 |
| _version_ | 1797666902515908608 |
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| author | Xiang Xiang Xinchen Zhu Lijuan Zhang |
| author_facet | Xiang Xiang Xinchen Zhu Lijuan Zhang |
| author_sort | Xiang Xiang |
| collection | DOAJ |
| description | Background. Acute kidney injury (AKI) is a complex clinical syndrome of hospitalization that may be affected by undernutrition and metabolic changes. The aim of this meta-analysis was to systematically assess the association between malnutrition and the risk of prevalent AKI. Materials and Methods. We searched PubMed, Embase, Ovid MEDLINE, Web of Science, and Chinese databases (WANFANG, VIP, and CKI) from database inception until May 1, 2023, for studies evaluating the association of malnutrition with the risk of AKI. Summary odds ratios (ORs) were estimated using a random-effects model. Results. We identified 17 observational studies, which included 273,315 individuals. Compared with patients with normal nutritional status, those with malnutrition had a 125% increased risk of prevalent AKI (pooled ORs, 2.25; 95% confidence interval, 1.80–2.82). Malnutrition was also significantly associated with prevalent AKI across all subgroups when subgroup analyses were performed on covariates such as region, study design, age, sample size, malnutrition assessment method, patient characteristics, covariate adjustment degree, and risk of bias. Meta-regression models demonstrated no significant differences in AKI risk between patients with malnutrition and without malnutrition. Conclusions. Our results suggest that malnutrition may be a potential target for AKI prevention. However, well-designed studies with ethnically or geographically diverse populations are needed to evaluate strategies and interventions to prevent or slow the development and progression of AKI in malnourished individuals. |
| first_indexed | 2024-03-11T20:05:22Z |
| format | Article |
| id | doaj.art-479b2fea28df4a35bfb046236bd1fc4e |
| institution | Directory Open Access Journal |
| issn | 1742-1241 |
| language | English |
| last_indexed | 2024-03-11T20:05:22Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi-Wiley |
| record_format | Article |
| series | International Journal of Clinical Practice |
| spelling | doaj.art-479b2fea28df4a35bfb046236bd1fc4e2023-10-04T00:00:04ZengHindawi-WileyInternational Journal of Clinical Practice1742-12412023-01-01202310.1155/2023/9910718Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-AnalysisXiang Xiang0Xinchen Zhu1Lijuan Zhang2Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of ChengduDepartment of Internal MedicineGeriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of ChengduBackground. Acute kidney injury (AKI) is a complex clinical syndrome of hospitalization that may be affected by undernutrition and metabolic changes. The aim of this meta-analysis was to systematically assess the association between malnutrition and the risk of prevalent AKI. Materials and Methods. We searched PubMed, Embase, Ovid MEDLINE, Web of Science, and Chinese databases (WANFANG, VIP, and CKI) from database inception until May 1, 2023, for studies evaluating the association of malnutrition with the risk of AKI. Summary odds ratios (ORs) were estimated using a random-effects model. Results. We identified 17 observational studies, which included 273,315 individuals. Compared with patients with normal nutritional status, those with malnutrition had a 125% increased risk of prevalent AKI (pooled ORs, 2.25; 95% confidence interval, 1.80–2.82). Malnutrition was also significantly associated with prevalent AKI across all subgroups when subgroup analyses were performed on covariates such as region, study design, age, sample size, malnutrition assessment method, patient characteristics, covariate adjustment degree, and risk of bias. Meta-regression models demonstrated no significant differences in AKI risk between patients with malnutrition and without malnutrition. Conclusions. Our results suggest that malnutrition may be a potential target for AKI prevention. However, well-designed studies with ethnically or geographically diverse populations are needed to evaluate strategies and interventions to prevent or slow the development and progression of AKI in malnourished individuals.http://dx.doi.org/10.1155/2023/9910718 |
| spellingShingle | Xiang Xiang Xinchen Zhu Lijuan Zhang Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis International Journal of Clinical Practice |
| title | Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis |
| title_full | Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis |
| title_fullStr | Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis |
| title_short | Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis |
| title_sort | association of malnutrition with risk of acute kidney injury a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2023/9910718 |
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