Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling
Ring finger protein 6 (RNF6) is implicated in various human malignancies, but its function in cervical cancer (CC) is incompletely understood. Here, we explored the biological significance of RNF6 in HeLa CC cells and the underlying regulatory mechanisms. The expression of RNF6 was observed to be hi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-07-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.13216 |
| _version_ | 1819144332891914240 |
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| author | Kang Zhu He Bai Mingzhu Mu Yuanyuan Xue Zhao Duan |
| author_facet | Kang Zhu He Bai Mingzhu Mu Yuanyuan Xue Zhao Duan |
| author_sort | Kang Zhu |
| collection | DOAJ |
| description | Ring finger protein 6 (RNF6) is implicated in various human malignancies, but its function in cervical cancer (CC) is incompletely understood. Here, we explored the biological significance of RNF6 in HeLa CC cells and the underlying regulatory mechanisms. The expression of RNF6 was observed to be high in both primary tissues and CC cells. RNF6 promoted HeLa CC cell growth. Knockdown of RNF6 in CC cells resulted in suppression of proliferation and promotion of apoptosis. Moreover, elevation of RNF6 had an adverse effect on the prognosis of CC. Subsequent analyses showed that these effects may be mediated via activation of ERK signaling. These findings provide evidence that the knockdown of RNF6 suppresses the MAPK/ERK pathway to regulate the growth of CC cells, which suggests that RNF6 may have potential as a target for diagnosis and treatment for CC. |
| first_indexed | 2024-12-22T12:40:28Z |
| format | Article |
| id | doaj.art-479c28ed82ce4a0f957f13bf015e326f |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-12-22T12:40:28Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-479c28ed82ce4a0f957f13bf015e326f2022-12-21T18:25:27ZengWileyFEBS Open Bio2211-54632021-07-011172041204910.1002/2211-5463.13216Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signalingKang Zhu0He Bai1Mingzhu Mu2Yuanyuan Xue3Zhao Duan4Department of Obstetrics and Gynecology The Second Affiliated Hospital Xi'an Jiaotong University ChinaDepartment of General Surgery Department The First Affiliated Hospital of Xi’an Medical University ChinaDepartment of Obstetrics and Gynecology The Second Affiliated Hospital Xi'an Jiaotong University ChinaDepartment of Obstetrics and Gynecology The Second Affiliated Hospital Xi'an Jiaotong University ChinaDepartment of Obstetrics and Gynecology The Second Affiliated Hospital Xi'an Jiaotong University ChinaRing finger protein 6 (RNF6) is implicated in various human malignancies, but its function in cervical cancer (CC) is incompletely understood. Here, we explored the biological significance of RNF6 in HeLa CC cells and the underlying regulatory mechanisms. The expression of RNF6 was observed to be high in both primary tissues and CC cells. RNF6 promoted HeLa CC cell growth. Knockdown of RNF6 in CC cells resulted in suppression of proliferation and promotion of apoptosis. Moreover, elevation of RNF6 had an adverse effect on the prognosis of CC. Subsequent analyses showed that these effects may be mediated via activation of ERK signaling. These findings provide evidence that the knockdown of RNF6 suppresses the MAPK/ERK pathway to regulate the growth of CC cells, which suggests that RNF6 may have potential as a target for diagnosis and treatment for CC.https://doi.org/10.1002/2211-5463.13216cell growthcervical cancerERKRNF6 |
| spellingShingle | Kang Zhu He Bai Mingzhu Mu Yuanyuan Xue Zhao Duan Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling FEBS Open Bio cell growth cervical cancer ERK RNF6 |
| title | Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling |
| title_full | Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling |
| title_fullStr | Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling |
| title_full_unstemmed | Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling |
| title_short | Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling |
| title_sort | knockdown of rnf6 inhibits hela cervical cancer cell growth via suppression of mapk erk signaling |
| topic | cell growth cervical cancer ERK RNF6 |
| url | https://doi.org/10.1002/2211-5463.13216 |
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