EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by perpetuated inflammation in multiple joints. To date, there is no cure for RA, and the causal factor for non-resolving inflammation in RA remains unclear. In this study, we initially observed expression of Epstein–Barr virus-...
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| Language: | English |
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Wiley
2013-11-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X13001034 |
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| author | Wen-Chan Chiu Ching-Mei Chen Tien-Tsai Cheng Huey-Ling You Shan-Fu Yu Lin-Hsiu Weng Hsuan-Ying Huang Chao-Cheng Huang Chung-Jen Chen |
| author_facet | Wen-Chan Chiu Ching-Mei Chen Tien-Tsai Cheng Huey-Ling You Shan-Fu Yu Lin-Hsiu Weng Hsuan-Ying Huang Chao-Cheng Huang Chung-Jen Chen |
| author_sort | Wen-Chan Chiu |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by perpetuated inflammation in multiple joints. To date, there is no cure for RA, and the causal factor for non-resolving inflammation in RA remains unclear. In this study, we initially observed expression of Epstein–Barr virus-encoded small RNA1 (EBER1) in the synovial tissue of all five patients who showed nonresolving RA inflammation. By contrast, EBER1 was detected in the synovial tissue of only one out of seven patients with advanced osteoarthritis (OA; p < 0.01, Fisher’s exact test). To confirm this finding, we conducted a second study on synovial tissue samples taken from 23 patients with nonresolving RA inflammation and 13 patients with OA. All synovial samples from patients with nonresolving inflammation of RA showed positive expression of EBER1 (23/23, 100%), whereas none of the synovial samples from patients with OA showed expression of EBER1 (0/13, 0%; p < 0.001, by Fisher’s exact test). In vitro, transfection of RA synovial fibroblasts with EBER1 induced the production of interleukin-6. Taken together, these data strongly suggest that nonresolving RA inflammation is strongly related to the presence of EBER1, which might be, at least partially, responsible for synovial fibroblast interleukin-6 production. |
| first_indexed | 2024-04-12T21:01:11Z |
| format | Article |
| id | doaj.art-479cffb991f44ef0a0ab7df9917421bf |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-04-12T21:01:11Z |
| publishDate | 2013-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-479cffb991f44ef0a0ab7df9917421bf2022-12-22T03:16:50ZengWileyKaohsiung Journal of Medical Sciences1607-551X2013-11-01291160661010.1016/j.kjms.2013.04.002EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritisWen-Chan Chiu0Ching-Mei Chen1Tien-Tsai Cheng2Huey-Ling You3Shan-Fu Yu4Lin-Hsiu Weng5Hsuan-Ying Huang6Chao-Cheng Huang7Chung-Jen Chen8Division of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Orthopedics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by perpetuated inflammation in multiple joints. To date, there is no cure for RA, and the causal factor for non-resolving inflammation in RA remains unclear. In this study, we initially observed expression of Epstein–Barr virus-encoded small RNA1 (EBER1) in the synovial tissue of all five patients who showed nonresolving RA inflammation. By contrast, EBER1 was detected in the synovial tissue of only one out of seven patients with advanced osteoarthritis (OA; p < 0.01, Fisher’s exact test). To confirm this finding, we conducted a second study on synovial tissue samples taken from 23 patients with nonresolving RA inflammation and 13 patients with OA. All synovial samples from patients with nonresolving inflammation of RA showed positive expression of EBER1 (23/23, 100%), whereas none of the synovial samples from patients with OA showed expression of EBER1 (0/13, 0%; p < 0.001, by Fisher’s exact test). In vitro, transfection of RA synovial fibroblasts with EBER1 induced the production of interleukin-6. Taken together, these data strongly suggest that nonresolving RA inflammation is strongly related to the presence of EBER1, which might be, at least partially, responsible for synovial fibroblast interleukin-6 production.http://www.sciencedirect.com/science/article/pii/S1607551X13001034EBER1InflammationRheumatoid arthritis |
| spellingShingle | Wen-Chan Chiu Ching-Mei Chen Tien-Tsai Cheng Huey-Ling You Shan-Fu Yu Lin-Hsiu Weng Hsuan-Ying Huang Chao-Cheng Huang Chung-Jen Chen EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis Kaohsiung Journal of Medical Sciences EBER1 Inflammation Rheumatoid arthritis |
| title | EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis |
| title_full | EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis |
| title_fullStr | EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis |
| title_full_unstemmed | EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis |
| title_short | EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis |
| title_sort | ebv encoded small rna1 and nonresolving inflammation in rheumatoid arthritis |
| topic | EBER1 Inflammation Rheumatoid arthritis |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X13001034 |
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