Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells
Mealworm and mealworm oil (MWO) have been reported to affect antioxidant, anti-coagulation, anti-adipogenic and anti-inflammatory activities. However, the function of MWO in wound healing is still unclear. In this study, we found that MWO induced the migration of fibroblast cells and mRNA expression...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/4/779 |
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| author | Joung-Hee Kim Eun-Yeong Kim Kyu Jin Chung Jung-Hee Lee Hee-Jung Choi Tae-Wook Chung Keuk-Jun Kim |
| author_facet | Joung-Hee Kim Eun-Yeong Kim Kyu Jin Chung Jung-Hee Lee Hee-Jung Choi Tae-Wook Chung Keuk-Jun Kim |
| author_sort | Joung-Hee Kim |
| collection | DOAJ |
| description | Mealworm and mealworm oil (MWO) have been reported to affect antioxidant, anti-coagulation, anti-adipogenic and anti-inflammatory activities. However, the function of MWO in wound healing is still unclear. In this study, we found that MWO induced the migration of fibroblast cells and mRNA expressions of wound healing factors such as alpha-smooth muscle actin (α-SMA), collagen-1 (COL-1) and vascular endothelial growth factor (VEGF) in fibroblast cells. The tube formation and migration of endothelial cells were promoted through the activation of VEGF/VEGF receptor-2 (VEGFR-2)-mediated downstream signals including AKT, extracellular signal-regulated kinase (ERK) and p38 by MWO-stimulated fibroblasts for angiogenesis. Moreover, we confirmed that MWO promoted skin wound repair by collagen synthesis, re-epithelialization and angiogenesis in an in vivo excisional wound model. These results demonstrate that MWO might have potential as a therapeutic agent for the treatment of skin wounds. |
| first_indexed | 2024-03-09T05:57:09Z |
| format | Article |
| id | doaj.art-479f640a642f42208b54155f0a974b87 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T05:57:09Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-479f640a642f42208b54155f0a974b872023-12-03T12:12:15ZengMDPI AGMolecules1420-30492021-02-0126477910.3390/molecules26040779Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial CellsJoung-Hee Kim0Eun-Yeong Kim1Kyu Jin Chung2Jung-Hee Lee3Hee-Jung Choi4Tae-Wook Chung5Keuk-Jun Kim6Department of Biomedical Laboratory Science, TaeKyeung University, 65, Danbuk 1-gil, Jain-myeon, Gyeongsan-si, Gyeongsangbuk-do 38547, KoreaAPROGEN, Inc., 545, Dunchon-daero, Jungwon-gu, Seongnam-si, Gyeonggi-do 13215, KoreaDepartment of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, 170, Hyeonchung-ro, Nam-gu, Daegu 42415, KoreaJIN BioCell Co., Ltd., #118-119, National Clinical Research Center for Korean Medicine, Pusan National University Korean Medicine Hospital, 20 Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, KoreaJIN BioCell Co., Ltd., #118-119, National Clinical Research Center for Korean Medicine, Pusan National University Korean Medicine Hospital, 20 Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, KoreaDepartment of Biomedical Laboratory Science, TaeKyeung University, 65, Danbuk 1-gil, Jain-myeon, Gyeongsan-si, Gyeongsangbuk-do 38547, KoreaDepartment of Biomedical Laboratory Science, TaeKyeung University, 65, Danbuk 1-gil, Jain-myeon, Gyeongsan-si, Gyeongsangbuk-do 38547, KoreaMealworm and mealworm oil (MWO) have been reported to affect antioxidant, anti-coagulation, anti-adipogenic and anti-inflammatory activities. However, the function of MWO in wound healing is still unclear. In this study, we found that MWO induced the migration of fibroblast cells and mRNA expressions of wound healing factors such as alpha-smooth muscle actin (α-SMA), collagen-1 (COL-1) and vascular endothelial growth factor (VEGF) in fibroblast cells. The tube formation and migration of endothelial cells were promoted through the activation of VEGF/VEGF receptor-2 (VEGFR-2)-mediated downstream signals including AKT, extracellular signal-regulated kinase (ERK) and p38 by MWO-stimulated fibroblasts for angiogenesis. Moreover, we confirmed that MWO promoted skin wound repair by collagen synthesis, re-epithelialization and angiogenesis in an in vivo excisional wound model. These results demonstrate that MWO might have potential as a therapeutic agent for the treatment of skin wounds.https://www.mdpi.com/1420-3049/26/4/779mealworm oilwound healingfibroblastsendothelial cellsmigration |
| spellingShingle | Joung-Hee Kim Eun-Yeong Kim Kyu Jin Chung Jung-Hee Lee Hee-Jung Choi Tae-Wook Chung Keuk-Jun Kim Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells Molecules mealworm oil wound healing fibroblasts endothelial cells migration |
| title | Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells |
| title_full | Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells |
| title_fullStr | Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells |
| title_full_unstemmed | Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells |
| title_short | Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells |
| title_sort | mealworm oil mwo enhances wound healing potential through the activation of fibroblast and endothelial cells |
| topic | mealworm oil wound healing fibroblasts endothelial cells migration |
| url | https://www.mdpi.com/1420-3049/26/4/779 |
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