Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women
The influence of the diet and nutritional status of milk donors on the nutritional composition of donor human milk (DHM) is unknown. The present study aimed to determine the nutritional profile of DHM and the associations between donors’ dietary intake and nutritional status and the micronutrient an...
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MDPI AG
2023-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/15/3486 |
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| author | Noelia Ureta-Velasco Adriana Montealegre-Pomar Kristin Keller Diana Escuder-Vieco Javier Fontecha María V. Calvo Javier Megino-Tello José C. E. Serrano Nadia Raquel García-Lara Carmen R. Pallás-Alonso |
| author_facet | Noelia Ureta-Velasco Adriana Montealegre-Pomar Kristin Keller Diana Escuder-Vieco Javier Fontecha María V. Calvo Javier Megino-Tello José C. E. Serrano Nadia Raquel García-Lara Carmen R. Pallás-Alonso |
| author_sort | Noelia Ureta-Velasco |
| collection | DOAJ |
| description | The influence of the diet and nutritional status of milk donors on the nutritional composition of donor human milk (DHM) is unknown. The present study aimed to determine the nutritional profile of DHM and the associations between donors’ dietary intake and nutritional status and the micronutrient and lipid composition in DHM. For this purpose, 113 donors completed a food frequency questionnaire, provided a five-day weighed dietary record, and collected milk for five consecutive days. Nutrient determinations in donors’ erythrocytes, plasma, urine, and milk were performed. Multiple linear regressions were conducted for the evaluation of the associations. We highlight the following results: DHM docosahexaenoic acid (DHA) was positively associated with donors’ plasma DHA content and donors’ DHA intake (R<sup>2</sup> 0.45, <i>p</i> < 0.001). For every 1 g/day DHA intake, an increase of 0.38% in DHA content and 0.78% in total omega-3 content was observed in DHM (R<sup>2</sup> 0.29, <i>p</i> < 0.001). DHM saturated fatty acids were positively associated with erythrocyte dimethyl acetals, plasma stearic acid, <i>trans</i> fatty acids intake, and breastfeeding duration and negatively associated with erythrocyte margaroleic acid (R<sup>2</sup> 0.34, <i>p</i> < 0.01). DHM cholecalciferol was associated with plasma cholecalciferol levels and dairy intake (R<sup>2</sup> 0.57, <i>p</i> < 0.01). Other weaker associations were found for free thiamin, free riboflavin, pyridoxal, dehydroascorbic acid, and the lipid profile in DHM. In conclusion, the diet and nutritional status of donors influence the fatty acid profile and micronutrient content of DHM. |
| first_indexed | 2024-03-11T00:19:26Z |
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| id | doaj.art-47a0a4537d974704b5ac4d8c9e95aad2 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:19:26Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-47a0a4537d974704b5ac4d8c9e95aad22023-11-18T23:25:12ZengMDPI AGNutrients2072-66432023-08-011515348610.3390/nu15153486Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor WomenNoelia Ureta-Velasco0Adriana Montealegre-Pomar1Kristin Keller2Diana Escuder-Vieco3Javier Fontecha4María V. Calvo5Javier Megino-Tello6José C. E. Serrano7Nadia Raquel García-Lara8Carmen R. Pallás-Alonso9Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, SpainEpidemiología Clínica, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá 110231, ColombiaResearch Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, SpainResearch Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, SpainFood Lipid Biomarkers and Health Group, Institute of Food Science Research (CIAL), CSIC-UAM, 28049 Madrid, SpainFood Lipid Biomarkers and Health Group, Institute of Food Science Research (CIAL), CSIC-UAM, 28049 Madrid, SpainFood Lipid Biomarkers and Health Group, Institute of Food Science Research (CIAL), CSIC-UAM, 28049 Madrid, SpainDepartment of Experimental Medicine, Faculty of Medicine, University of Lleida, 25008 Lleida, SpainDepartment of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, SpainDepartment of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, SpainThe influence of the diet and nutritional status of milk donors on the nutritional composition of donor human milk (DHM) is unknown. The present study aimed to determine the nutritional profile of DHM and the associations between donors’ dietary intake and nutritional status and the micronutrient and lipid composition in DHM. For this purpose, 113 donors completed a food frequency questionnaire, provided a five-day weighed dietary record, and collected milk for five consecutive days. Nutrient determinations in donors’ erythrocytes, plasma, urine, and milk were performed. Multiple linear regressions were conducted for the evaluation of the associations. We highlight the following results: DHM docosahexaenoic acid (DHA) was positively associated with donors’ plasma DHA content and donors’ DHA intake (R<sup>2</sup> 0.45, <i>p</i> < 0.001). For every 1 g/day DHA intake, an increase of 0.38% in DHA content and 0.78% in total omega-3 content was observed in DHM (R<sup>2</sup> 0.29, <i>p</i> < 0.001). DHM saturated fatty acids were positively associated with erythrocyte dimethyl acetals, plasma stearic acid, <i>trans</i> fatty acids intake, and breastfeeding duration and negatively associated with erythrocyte margaroleic acid (R<sup>2</sup> 0.34, <i>p</i> < 0.01). DHM cholecalciferol was associated with plasma cholecalciferol levels and dairy intake (R<sup>2</sup> 0.57, <i>p</i> < 0.01). Other weaker associations were found for free thiamin, free riboflavin, pyridoxal, dehydroascorbic acid, and the lipid profile in DHM. In conclusion, the diet and nutritional status of donors influence the fatty acid profile and micronutrient content of DHM.https://www.mdpi.com/2072-6643/15/15/3486breast milkhuman milk bankassociationsdonorsdietnutritional status |
| spellingShingle | Noelia Ureta-Velasco Adriana Montealegre-Pomar Kristin Keller Diana Escuder-Vieco Javier Fontecha María V. Calvo Javier Megino-Tello José C. E. Serrano Nadia Raquel García-Lara Carmen R. Pallás-Alonso Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women Nutrients breast milk human milk bank associations donors diet nutritional status |
| title | Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women |
| title_full | Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women |
| title_fullStr | Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women |
| title_full_unstemmed | Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women |
| title_short | Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women |
| title_sort | associations of dietary intake and nutrient status with micronutrient and lipid composition in breast milk of donor women |
| topic | breast milk human milk bank associations donors diet nutritional status |
| url | https://www.mdpi.com/2072-6643/15/15/3486 |
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