Description of a Novel Mechanism Possibly Explaining the Antiproliferative Properties of Glucocorticoids in Duchenne Muscular Dystrophy Fibroblasts Based on Glucocorticoid Receptor GR and NFAT5

Description of a Novel Mechanism Possibly Explaining the Antiproliferative Properties of Glucocorticoids in Duchenne Muscular Dystrophy Fibroblasts Based on Glucocorticoid Receptor GR and NFAT5

Glucocorticoids are drugs of choice in Duchenne muscular dystrophy (DMD), prolonging patients’ ambulation. Their mode of action at the protein level is not completely understood. In DMD, muscle tissue is replaced by fibrotic tissue produced by fibroblasts, reducing mobility. Nuclear factor of activa...

Full description

Bibliographic Details
Main Authors: Sandrine Herbelet, Boel De Paepe, Jan L. De Bleecker
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
Duchenne muscular dystrophy fibroblasts
methylprednisolone
hydrocortisone
reduction in proliferation
glucocorticoid receptor
NFAT5
Online Access:https://www.mdpi.com/1422-0067/21/23/9225

Similar Items

Similar Items