Why Is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds
We anchored a colourimetric probe, comprising a complex containing copper (Cu(II)) and a dye, to a polymer matrix obtaining film-shaped chemosensors with induced selectivity toward glycine. This sensory material is exploited in the selectivity detection of glycine in complex mixtures of amino acids...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/6/1249 |
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| author | Marta Guembe-García Patricia D. Peredo-Guzmán Victoria Santaolalla-García Natalia Moradillo-Renuncio Saturnino Ibeas Aranzazu Mendía Félix Clemente García José Miguel García Saúl Vallejos |
| author_facet | Marta Guembe-García Patricia D. Peredo-Guzmán Victoria Santaolalla-García Natalia Moradillo-Renuncio Saturnino Ibeas Aranzazu Mendía Félix Clemente García José Miguel García Saúl Vallejos |
| author_sort | Marta Guembe-García |
| collection | DOAJ |
| description | We anchored a colourimetric probe, comprising a complex containing copper (Cu(II)) and a dye, to a polymer matrix obtaining film-shaped chemosensors with induced selectivity toward glycine. This sensory material is exploited in the selectivity detection of glycine in complex mixtures of amino acids mimicking elastin, collagen and epidermis, and also in following the protease activity in a beefsteak and chronic human wounds. We use the term inducing because the probe in solution is not selective toward any amino acid and we get selectivity toward glycine using the solid-state. Overall, we found that the chemical behaviour of a chemical probe can be entirely changed by changing its chemical environment. Regarding its behaviour in solution, this change has been achieved by isolating the probe by anchoring the motifs in a polymer matrix, in an amorphous state, avoiding the interaction of one sensory motif with another. Moreover, this selectivity change can be further tuned because of the effectiveness of the transport of targets both by the physical nature of the interface of the polymer matrix/solution, where the target chemicals are dissolved, for instance, and inside the matrix where the recognition takes place. The interest in chronic human wounds is related to the fact that our methods are rapid and inexpensive, and also considering that the protease activity can correlate with the evolution of chronic wounds. |
| first_indexed | 2024-03-10T19:29:31Z |
| format | Article |
| id | doaj.art-47a256ca5d894898954437ca5a88b9ef |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T19:29:31Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-47a256ca5d894898954437ca5a88b9ef2023-11-20T02:14:22ZengMDPI AGPolymers2073-43602020-05-01126124910.3390/polym12061249Why Is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic WoundsMarta Guembe-García0Patricia D. Peredo-Guzmán1Victoria Santaolalla-García2Natalia Moradillo-Renuncio3Saturnino Ibeas4Aranzazu Mendía5Félix Clemente García6José Miguel García7Saúl Vallejos8Departamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Bañuelos s/n, 09001 Burgos, SpainDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Bañuelos s/n, 09001 Burgos, SpainComplejo Asistencial Universitario de Burgos, 09001 Burgos, SpainComplejo Asistencial Universitario de Burgos, 09001 Burgos, SpainDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Bañuelos s/n, 09001 Burgos, SpainDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Bañuelos s/n, 09001 Burgos, SpainDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Bañuelos s/n, 09001 Burgos, SpainDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Bañuelos s/n, 09001 Burgos, SpainDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Bañuelos s/n, 09001 Burgos, SpainWe anchored a colourimetric probe, comprising a complex containing copper (Cu(II)) and a dye, to a polymer matrix obtaining film-shaped chemosensors with induced selectivity toward glycine. This sensory material is exploited in the selectivity detection of glycine in complex mixtures of amino acids mimicking elastin, collagen and epidermis, and also in following the protease activity in a beefsteak and chronic human wounds. We use the term inducing because the probe in solution is not selective toward any amino acid and we get selectivity toward glycine using the solid-state. Overall, we found that the chemical behaviour of a chemical probe can be entirely changed by changing its chemical environment. Regarding its behaviour in solution, this change has been achieved by isolating the probe by anchoring the motifs in a polymer matrix, in an amorphous state, avoiding the interaction of one sensory motif with another. Moreover, this selectivity change can be further tuned because of the effectiveness of the transport of targets both by the physical nature of the interface of the polymer matrix/solution, where the target chemicals are dissolved, for instance, and inside the matrix where the recognition takes place. The interest in chronic human wounds is related to the fact that our methods are rapid and inexpensive, and also considering that the protease activity can correlate with the evolution of chronic wounds.https://www.mdpi.com/2073-4360/12/6/1249solid-state chemosensorssensory polymersamino acidschronic wounds |
| spellingShingle | Marta Guembe-García Patricia D. Peredo-Guzmán Victoria Santaolalla-García Natalia Moradillo-Renuncio Saturnino Ibeas Aranzazu Mendía Félix Clemente García José Miguel García Saúl Vallejos Why Is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds Polymers solid-state chemosensors sensory polymers amino acids chronic wounds |
| title | Why Is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds |
| title_full | Why Is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds |
| title_fullStr | Why Is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds |
| title_full_unstemmed | Why Is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds |
| title_short | Why Is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds |
| title_sort | why is the sensory response of organic probes within a polymer film different in solution and in the solid state evidence and application to the detection of amino acids in human chronic wounds |
| topic | solid-state chemosensors sensory polymers amino acids chronic wounds |
| url | https://www.mdpi.com/2073-4360/12/6/1249 |
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