Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c
Cellular stress response is coordinated through the communication between mitochondria and the nucleus. However, whereas mitochondria are regulated by nuclear-encoded proteins, the nucleus was considered ungoverned by mitochondrial-encoded factors. We recently reported that a mitochondrial-encoded p...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-03-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1549464 |
| _version_ | 1797677142171975680 |
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| author | Changhan Lee |
| author_facet | Changhan Lee |
| author_sort | Changhan Lee |
| collection | DOAJ |
| description | Cellular stress response is coordinated through the communication between mitochondria and the nucleus. However, whereas mitochondria are regulated by nuclear-encoded proteins, the nucleus was considered ungoverned by mitochondrial-encoded factors. We recently reported that a mitochondrial-encoded peptide directly regulates the nuclear genome upon cellular stress, indicating an integrated bi-genomic cross-communication mechanism. |
| first_indexed | 2024-03-11T22:40:38Z |
| format | Article |
| id | doaj.art-47a3c4054d5f464c9c3338e87fa096f7 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:38Z |
| publishDate | 2019-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-47a3c4054d5f464c9c3338e87fa096f72023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-03-01621210.1080/23723556.2018.15494641549464Nuclear transcriptional regulation by mitochondrial-encoded MOTS-cChanghan Lee0University of Southern CaliforniaCellular stress response is coordinated through the communication between mitochondria and the nucleus. However, whereas mitochondria are regulated by nuclear-encoded proteins, the nucleus was considered ungoverned by mitochondrial-encoded factors. We recently reported that a mitochondrial-encoded peptide directly regulates the nuclear genome upon cellular stress, indicating an integrated bi-genomic cross-communication mechanism.http://dx.doi.org/10.1080/23723556.2018.1549464mitochondriamitonuclear communicationmitochondrial-derived peptidesmdpsmots-cnuclear translocationadaptive gene expressionstress responsestress resistancehomeostasis |
| spellingShingle | Changhan Lee Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c Molecular & Cellular Oncology mitochondria mitonuclear communication mitochondrial-derived peptides mdps mots-c nuclear translocation adaptive gene expression stress response stress resistance homeostasis |
| title | Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c |
| title_full | Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c |
| title_fullStr | Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c |
| title_full_unstemmed | Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c |
| title_short | Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c |
| title_sort | nuclear transcriptional regulation by mitochondrial encoded mots c |
| topic | mitochondria mitonuclear communication mitochondrial-derived peptides mdps mots-c nuclear translocation adaptive gene expression stress response stress resistance homeostasis |
| url | http://dx.doi.org/10.1080/23723556.2018.1549464 |
| work_keys_str_mv | AT changhanlee nucleartranscriptionalregulationbymitochondrialencodedmotsc |