Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials
Abstract Background Sarcopenia is a chronic disease marked by gradual muscle system and functional decline. Prior research indicates its prevalence in those under 60 varies from 8 to 36%. There is limited evidence on the effectiveness of non-pharmacological interventions for sarcopenia prevention in...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-11-01
|
| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-023-02749-7 |
| _version_ | 1797556774708969472 |
|---|---|
| author | Ting-Wan Tan Han-Ling Tan Min-Fang Hsu Hsiao-Ling Huang Yu-Chu Chung |
| author_facet | Ting-Wan Tan Han-Ling Tan Min-Fang Hsu Hsiao-Ling Huang Yu-Chu Chung |
| author_sort | Ting-Wan Tan |
| collection | DOAJ |
| description | Abstract Background Sarcopenia is a chronic disease marked by gradual muscle system and functional decline. Prior research indicates its prevalence in those under 60 varies from 8 to 36%. There is limited evidence on the effectiveness of non-pharmacological interventions for sarcopenia prevention in menopausal women aged 40–60. This study examines the influence of such interventions for sarcopenia prevention on these women. Methods PubMed, EMBASE, Medline, Cochrane Library, CINAHL, PEDro, and Airiti Library were searched from inception until May 5, 2023. Randomized controlled trials that examined exercise, vitamin D and protein supplementation effects on muscle mass, strength, and physical function. Quality assessment used the Cochrane risk of bias tool, and analysis employed Comprehensive Meta-Analysis version 2.0. Results A total of 27 randomized controlled trials, involving 1,989 participants were identified. Meta-analysis results showed exercise improved lean body mass (SMD = 0.232, 95% CI: 0.097, 0.366), handgrip strength (SMD = 0.901, 95% CI: 0.362, 1.441), knee extension strength (SMD = 0.698, 95% CI: 0.384, 1.013). Resistance training had a small effect on lean body mass, longer exercise duration (> 12 weeks) and higher frequency (60–90 min, 3 sessions/week) showed small to moderate effects on lean body mass. Vitamin D supplementation improved handgrip strength (SMD = 0.303, 95% CI: 0.130, 0.476), but not knee extension strength. There was insufficient data to assess the impact of protein supplementation on muscle strength. Conclusions Exercise effectively improves muscle mass, and strength in menopausal women. Resistance training with 3 sessions per week, lasting 20–90 min for at least 6 weeks, is most effective. Vitamin D supplementation enhances small muscle group strength. Further trials are needed to assess the effects of vitamin D and protein supplementation on sarcopenia prevention. Registration number This review was registered on PROSPERO CRD42022329273. |
| first_indexed | 2024-03-10T17:06:46Z |
| format | Article |
| id | doaj.art-47a3e80e76984984976a13f8a608e46e |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-03-10T17:06:46Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-47a3e80e76984984976a13f8a608e46e2023-11-20T10:46:38ZengBMCBMC Women's Health1472-68742023-11-0123111810.1186/s12905-023-02749-7Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trialsTing-Wan Tan0Han-Ling Tan1Min-Fang Hsu2Hsiao-Ling Huang3Yu-Chu Chung4Department of Nursing, Hsinchu MacKay Memorial HospitalDepartment of Orthopaedic Surgery, Faculty of Medicine, University of MalayaDepartment of Nursing, Yuanpei University of Medical TechnologyDepartment of Healthcare Management, Yuanpei University of Medical TechnologyDepartment of Nursing, Yuanpei University of Medical TechnologyAbstract Background Sarcopenia is a chronic disease marked by gradual muscle system and functional decline. Prior research indicates its prevalence in those under 60 varies from 8 to 36%. There is limited evidence on the effectiveness of non-pharmacological interventions for sarcopenia prevention in menopausal women aged 40–60. This study examines the influence of such interventions for sarcopenia prevention on these women. Methods PubMed, EMBASE, Medline, Cochrane Library, CINAHL, PEDro, and Airiti Library were searched from inception until May 5, 2023. Randomized controlled trials that examined exercise, vitamin D and protein supplementation effects on muscle mass, strength, and physical function. Quality assessment used the Cochrane risk of bias tool, and analysis employed Comprehensive Meta-Analysis version 2.0. Results A total of 27 randomized controlled trials, involving 1,989 participants were identified. Meta-analysis results showed exercise improved lean body mass (SMD = 0.232, 95% CI: 0.097, 0.366), handgrip strength (SMD = 0.901, 95% CI: 0.362, 1.441), knee extension strength (SMD = 0.698, 95% CI: 0.384, 1.013). Resistance training had a small effect on lean body mass, longer exercise duration (> 12 weeks) and higher frequency (60–90 min, 3 sessions/week) showed small to moderate effects on lean body mass. Vitamin D supplementation improved handgrip strength (SMD = 0.303, 95% CI: 0.130, 0.476), but not knee extension strength. There was insufficient data to assess the impact of protein supplementation on muscle strength. Conclusions Exercise effectively improves muscle mass, and strength in menopausal women. Resistance training with 3 sessions per week, lasting 20–90 min for at least 6 weeks, is most effective. Vitamin D supplementation enhances small muscle group strength. Further trials are needed to assess the effects of vitamin D and protein supplementation on sarcopenia prevention. Registration number This review was registered on PROSPERO CRD42022329273.https://doi.org/10.1186/s12905-023-02749-7Menopausal womenExercise trainingVitamin DProteinSarcopeniaSystematic review |
| spellingShingle | Ting-Wan Tan Han-Ling Tan Min-Fang Hsu Hsiao-Ling Huang Yu-Chu Chung Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials BMC Women's Health Menopausal women Exercise training Vitamin D Protein Sarcopenia Systematic review |
| title | Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials |
| title_full | Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials |
| title_short | Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | effect of non pharmacological interventions on the prevention of sarcopenia in menopausal women a systematic review and meta analysis of randomized controlled trials |
| topic | Menopausal women Exercise training Vitamin D Protein Sarcopenia Systematic review |
| url | https://doi.org/10.1186/s12905-023-02749-7 |
| work_keys_str_mv | AT tingwantan effectofnonpharmacologicalinterventionsonthepreventionofsarcopeniainmenopausalwomenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT hanlingtan effectofnonpharmacologicalinterventionsonthepreventionofsarcopeniainmenopausalwomenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT minfanghsu effectofnonpharmacologicalinterventionsonthepreventionofsarcopeniainmenopausalwomenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT hsiaolinghuang effectofnonpharmacologicalinterventionsonthepreventionofsarcopeniainmenopausalwomenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT yuchuchung effectofnonpharmacologicalinterventionsonthepreventionofsarcopeniainmenopausalwomenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |