Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness

Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness

Abstract Background Critically ill children suffer from impaired physical/neurocognitive development 2 years later. Glucocorticoid treatment alters DNA methylation within the hypothalamus–pituitary–adrenal (HPA) axis which may impair normal brain development, cognition and behaviour. We tested the h...

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Bibliographic Details
Main Authors: Grégoire Coppens, Ilse Vanhorebeek, Fabian Güiza, Inge Derese, Pieter J. Wouters, Arno Téblick, Karolijn Dulfer, Koen F. Joosten, Sascha C. Verbruggen, Greet Van den Berghe
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Clinical Epigenetics
Subjects:
Critical illness
Children
DNA methylation
HPA axis
Glucocorticoid
Long-term outcome
Online Access:https://doi.org/10.1186/s13148-024-01640-y

Internet

https://doi.org/10.1186/s13148-024-01640-y

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