Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness
Abstract Background Critically ill children suffer from impaired physical/neurocognitive development 2 years later. Glucocorticoid treatment alters DNA methylation within the hypothalamus–pituitary–adrenal (HPA) axis which may impair normal brain development, cognition and behaviour. We tested the h...
Main Authors: | Grégoire Coppens, Ilse Vanhorebeek, Fabian Güiza, Inge Derese, Pieter J. Wouters, Arno Téblick, Karolijn Dulfer, Koen F. Joosten, Sascha C. Verbruggen, Greet Van den Berghe |
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Format: | Article |
Language: | English |
Published: |
BMC
2024-02-01
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Series: | Clinical Epigenetics |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13148-024-01640-y |
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