Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populations
AimsTo investigate the potential association between type 2 diabetes (T2D) and hepatocellular carcinoma (HCC) in East Asian populations using Mendelian randomization (MR) analyses.MethodsBidirectional Mendelian randomization (MR) studies were conducted using summary statistics from genome-wide assoc...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1308561/full |
| _version_ | 1797367673337675776 |
|---|---|
| author | Jinlong Huo Jinlong Huo Yaxuan Xu Xingqi Chen Jie Yu Lijin Zhao |
| author_facet | Jinlong Huo Jinlong Huo Yaxuan Xu Xingqi Chen Jie Yu Lijin Zhao |
| author_sort | Jinlong Huo |
| collection | DOAJ |
| description | AimsTo investigate the potential association between type 2 diabetes (T2D) and hepatocellular carcinoma (HCC) in East Asian populations using Mendelian randomization (MR) analyses.MethodsBidirectional Mendelian randomization (MR) studies were conducted using summary statistics from genome-wide association studies (GWAS) related to T2D and HCC. The potential effects of confounders such as chronic hepatitis B, chronic hepatitis C, body mass index, and alcohol intake frequency were corrected using a multivariate MR study. Various MR methods, including the inverse variance weighted (IVW) approach, were used to estimate the associations between T2D and HCC. Sensitivity analysis and assessment of heterogeneity were performed to ensure the robustness of the results.ResultsIn the forward MR study, the IVW approach of MR analysis suggested an inverse association between T2D and HCC, with a risk odds ratio of 0.8628 (95% confidence interval [CI], 0.7888–0.9438). Furthermore, even after adjusting for BMI, chronic hepatitis B, and alcohol intake frequency, this study still supports the inverse association between T2D and HCC. Additional MR methods provided further support for this relationship. Sensitivity analysis and assessment of heterogeneity confirmed the robustness of the results. The reverse MR analysis did not show a clear impact of genetic liability to HCC on reduced risk of T2D(OR=0.9788; 95% CI, 0.9061-1.0574).ConclusionThis study provides evidence of an inverse association between T2D and HCC in East Asian populations using MR analysis. Further studies are warranted to validate these findings. |
| first_indexed | 2024-03-08T17:21:39Z |
| format | Article |
| id | doaj.art-47a68106d6a64cf19b8dc427c8936cce |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T17:21:39Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-47a68106d6a64cf19b8dc427c8936cce2024-01-03T04:38:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.13085611308561Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populationsJinlong Huo0Jinlong Huo1Yaxuan Xu2Xingqi Chen3Jie Yu4Lijin Zhao5Department of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Breast and Thyroid Surgery, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, ChinaDepartment of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaAimsTo investigate the potential association between type 2 diabetes (T2D) and hepatocellular carcinoma (HCC) in East Asian populations using Mendelian randomization (MR) analyses.MethodsBidirectional Mendelian randomization (MR) studies were conducted using summary statistics from genome-wide association studies (GWAS) related to T2D and HCC. The potential effects of confounders such as chronic hepatitis B, chronic hepatitis C, body mass index, and alcohol intake frequency were corrected using a multivariate MR study. Various MR methods, including the inverse variance weighted (IVW) approach, were used to estimate the associations between T2D and HCC. Sensitivity analysis and assessment of heterogeneity were performed to ensure the robustness of the results.ResultsIn the forward MR study, the IVW approach of MR analysis suggested an inverse association between T2D and HCC, with a risk odds ratio of 0.8628 (95% confidence interval [CI], 0.7888–0.9438). Furthermore, even after adjusting for BMI, chronic hepatitis B, and alcohol intake frequency, this study still supports the inverse association between T2D and HCC. Additional MR methods provided further support for this relationship. Sensitivity analysis and assessment of heterogeneity confirmed the robustness of the results. The reverse MR analysis did not show a clear impact of genetic liability to HCC on reduced risk of T2D(OR=0.9788; 95% CI, 0.9061-1.0574).ConclusionThis study provides evidence of an inverse association between T2D and HCC in East Asian populations using MR analysis. Further studies are warranted to validate these findings.https://www.frontiersin.org/articles/10.3389/fendo.2023.1308561/fulltype 2 diabeteshepatocellular carcinomaMendelian randomizationEast Asian populationsassociation |
| spellingShingle | Jinlong Huo Jinlong Huo Yaxuan Xu Xingqi Chen Jie Yu Lijin Zhao Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populations Frontiers in Endocrinology type 2 diabetes hepatocellular carcinoma Mendelian randomization East Asian populations association |
| title | Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populations |
| title_full | Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populations |
| title_fullStr | Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populations |
| title_full_unstemmed | Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populations |
| title_short | Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populations |
| title_sort | inverse association between type 2 diabetes and hepatocellular carcinoma in east asian populations |
| topic | type 2 diabetes hepatocellular carcinoma Mendelian randomization East Asian populations association |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1308561/full |
| work_keys_str_mv | AT jinlonghuo inverseassociationbetweentype2diabetesandhepatocellularcarcinomaineastasianpopulations AT jinlonghuo inverseassociationbetweentype2diabetesandhepatocellularcarcinomaineastasianpopulations AT yaxuanxu inverseassociationbetweentype2diabetesandhepatocellularcarcinomaineastasianpopulations AT xingqichen inverseassociationbetweentype2diabetesandhepatocellularcarcinomaineastasianpopulations AT jieyu inverseassociationbetweentype2diabetesandhepatocellularcarcinomaineastasianpopulations AT lijinzhao inverseassociationbetweentype2diabetesandhepatocellularcarcinomaineastasianpopulations |