Meniscus cell lysate induces mitochondrial dysfunction of fibroblast-like synoviocytes via upregulating ANT3 in osteoarthritis: aNT3 is a potentially important novel mediator and drug target in osteoarthritis

Meniscus cell lysate induces mitochondrial dysfunction of fibroblast-like synoviocytes via upregulating ANT3 in osteoarthritis: aNT3 is a potentially important novel mediator and drug target in osteoarthritis

Aims: This study aimed to investigate the role and mechanism of meniscal cell lysate (MCL) in fibroblast-like synoviocytes (FLSs) and osteoarthritis (OA). Methods: Meniscus and synovial tissue were collected from 14 patients with and without OA. MCL and FLS proteins were extracted and analyzed by li...

Full description

Bibliographic Details
Main Authors: Xue Du, Zongrui Jiang, Guibin Fang, Ruonan Liu, Xingzhao Wen, Yinjuan Wu, Shu Hu, Zhiqi Zhang
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-04-01
Series:Bone & Joint Research
Subjects:
osteoarthritis
meniscal cell lysate
fibroblast-like synoviocyte
adenine nucleotide translocase 3
mitochondrial dysfunction
osteoarthritis (oa)
meniscus cells
fibroblast-like synoviocytes (flss)
synovitis
enzyme-linked immunosorbent assay
synovial inflammation
synovial fluids
synovial tissues
mitochondria
flow cytometry
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.124.BJR-2022-0135.R2

Similar Items

Similar Items